Abstract：
RESEARCH QUESTION:Does extending the follow-up after misoprostol treatment for early pregnancy loss increase the success rate? DESIGN:Patients who had experienced early pregnancy loss (<12 weeks) and were treated with misoprostol in a single university-affiliated medical centre were prospectively followed before and after the implementation of a new treatment protocol extending the follow-up from 1 to 2 weeks. All patients received misoprostol 800 μg vaginally on day 1 and a second dose, when needed, on day 4 or 8. Patients underwent surgical aspiration after 1 week in the early follow-up group (n = 84) or 2 weeks in the delayed follow-up group (n = 85) if complete expulsion was not achieved (defined as endometrial thickness ≤15 mm and absence of gestational sac on transvaginal sonography). The primary outcome was treatment success, defined as no need for surgical aspiration. RESULTS:Women in the delayed follow-up group had a higher rate of successful treatment compared with women in the early follow-up group (88.2% versus 76.2%, respectively; P = 0.040), and a lower rate of second dose administration (32.9% versus 51.2%, respectively; P = 0.016). The incidence of non-expulsion of the gestational sac was also lower in the delayed follow-up group (1.2% versus 10.7%; P = 0.009). Treatment acceptability did not differ between the study groups. CONCLUSION:In women with early pregnancy loss treated with misoprostol, extending the follow-up protocol from 1 to 2 weeks resulted in an increase in treatment success.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Mizrachi Y,Tamayev L,Shemer O,Kleiner I,Bar J,Sagiv Rdoi
10.1016/j.rbmo.2019.02.011subject
Has Abstractpub_date
2019-07-01 00:00:00pages
155-160issue
1eissn
1472-6483issn
1472-6491pii
S1472-6483(19)30237-8journal_volume
39pub_type
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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