New treatments for chronic hepatitis C: an overview for paediatricians.

Abstract:

:Pegylated interferon (IFN) α-2a or 2b in combination with ribavirin for children aged 3 years and older is the standard treatment for paediatric chronic hepatitis C. This treatment regimen was developed firstly in adults. In recent years, a number of direct-acting antiviral agents (DAAs) are under development for treatment of chronic hepatitis C virus (HCV) infection. These agents block viral replication inhibiting directly one of the several steps of HCV lifecycle. DAAs are classified into several categories based on their molecular target: HCV NS3/4A protease inhibitors, HCV NS5B polymerase inhibitors and HCV NS5A inhibitors. Other promising compounds are cyclophilin A inhibitors, mi-RNA122 and IFN-λ. Several new drugs associations will be developed in the near future starting from the actual standard of care. IFN-based and IFN-free regimens are being studied in adults. In this constantly evolving scenario new drug regimens targeted and suitable for children would be possible in the next future. Especially for children, it is crucial to identify the right combination of drugs with the highest potency, barrier to resistance and the best safety profile.

journal_name

World J Gastroenterol

authors

Serranti D,Indolfi G,Resti M

doi

10.3748/wjg.v20.i43.15965

subject

Has Abstract

pub_date

2014-11-21 00:00:00

pages

15965-74

issue

43

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章,评审
  • Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant.

    abstract:AIM:To assess whether the use of fibrin sealant shortens the closure time of postoperative enterocutaneous fistulas (ECFs). METHODS:The prospective case-control study included 70 patients with postoperative ECFs with an output of < 500 mL/d, a fistulous tract of > 2 cm and without any local complication. They were div...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i22.2793

    authors: Avalos-González J,Portilla-deBuen E,Leal-Cortés CA,Orozco-Mosqueda A,Estrada-Aguilar Mdel C,Velázquez-Ramírez GA,Ambriz-González G,Fuentes-Orozco C,Guzmán-Gurrola AE,González-Ojeda A

    更新日期:2010-06-14 00:00:00

  • Association of erectile dysfunction with depression in patients with chronic viral hepatitis.

    abstract:AIM:To investigate the prevalence of erectile dysfunction (ED) and its association with depression in patients with chronic viral hepatitis. METHODS:This single center cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis in our liver clinic between 18 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i18.5641

    authors: Ma BO,Shim SG,Yang HJ

    更新日期:2015-05-14 00:00:00

  • Kudo's pit pattern classification for colorectal neoplasms: a meta-analysis.

    abstract:AIM:To analyze the current available evidence of Kudo's pit pattern classification for diagnosing colorectal neoplasms. METHODS:A search was performed on Pubmed/Embase to identify studies reporting the outcomes of the pit pattern classification in colorectal polyps. Retrieved records were evaluated and selected by two...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i35.12649

    authors: Li M,Ali SM,Umm-a-OmarahGilani S,Liu J,Li YQ,Zuo XL

    更新日期:2014-09-21 00:00:00

  • Replication and gene expression of mutant hepatitis B virus in a transgenic mouse containing the complete viral genome with mutant s gene.

    abstract:AIM:To establish the transgenic mouse line harbouring complete hepatitis B virus (HBV) genome with mutant s gene (adr subtype). METHODS:Transgenic mice were generated by microinjecting HBV genome into fertilized eggs. Integration, expression, replication of HBV gene and histological changes in transgenic mice were est...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i21.3141

    authors: Ge JH,Zhang LZ,Li JX,Liu H,Liu HM,He J,Yao YC,Yang YJ,Yu HY,Hu YP

    更新日期:2004-11-01 00:00:00

  • Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.

    abstract::To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and S...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.14.4721

    authors: Schimanski CC,Galle PR,Moehler M

    更新日期:2008-08-14 00:00:00

  • Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife.

    abstract:AIM:To determine short- and long-term outcomes of endoscopic submucosal dissection (ESD) using the stag beetle (SB) knife, a scissor-shaped device. METHODS:Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, betwee...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i15.1632

    authors: Kuwai T,Yamaguchi T,Imagawa H,Miura R,Sumida Y,Takasago T,Miyasako Y,Nishimura T,Iio S,Yamaguchi A,Kouno H,Kohno H,Ishaq S

    更新日期:2018-04-21 00:00:00

  • Learning curve for hand-assisted laparoscopic D2 radical gastrectomy.

    abstract:AIM:To describe the learning curves of hand-assisted laparoscopic D2 radical gastrectomy (HALG) for the treatment of gastric cancer. METHODS:The HALG surgical procedure consists of three stages: surgery under direct vision via the port for hand assistance, hand-assisted laparoscopic surgery, and gastrointestinal tract...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i5.1606

    authors: Gong JQ,Cao YK,Wang YH,Zhang GH,Wang PH,Luo GD

    更新日期:2015-02-07 00:00:00

  • Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis.

    abstract:AIM:To clarify the effectiveness of plasma exchange by comparing the mortality and morbidity before and after the intervention of plasma exchange. METHODS:Plasma exchange has been available as an optional therapy for hyperlipidemic pancreatitis since August 1999 in our hospital. The patients were assorted into 2 group...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i15.2272

    authors: Chen JH,Yeh JH,Lai HW,Liao CS

    更新日期:2004-08-01 00:00:00

  • Microscopic colitis.

    abstract::Microscopic colitis may be defined as a clinical syndrome, of unknown etiology, consisting of chronic watery diarrhea, with no alterations in the large bowel at the endoscopic and radiologic evaluation. Therefore, a definitive diagnosis is only possible by histological analysis. The epidemiological impact of this dise...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i43.6206

    authors: Ianiro G,Cammarota G,Valerio L,Annicchiarico BE,Milani A,Siciliano M,Gasbarrini A

    更新日期:2012-11-21 00:00:00

  • Preparation of monoclonal antibody against apoptosis-associated antigens of hepatoma cells by subtractive immunization.

    abstract:AIM:To elucidate the expression of the apoptosis-associated molecules in human primary hepatocellular carcinoma (HCC) cells, and prepare the monoclonal antibodies (mAb) against the apoptosis-associated antigens of HCC cells. METHODS:Human HCC cell line HCC-9204 cells were induced apoptosis with 60 mL x L(-1) ethanol f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i5.808

    authors: Yang LJ,Wang WL

    更新日期:2002-10-01 00:00:00

  • Treatment options in patients with metastatic gastric cancer: current status and future perspectives.

    abstract::Despite advances in the treatment of gastric cancer, it remains the world's second highest cause of cancer death. As gastric cancer is often diagnosed at an advanced stage, systemic chemotherapy is the mainstay of treatment for these patients. However, no standard palliative chemotherapy regimen has been accepted for ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i14.3905

    authors: Bilici A

    更新日期:2014-04-14 00:00:00

  • Rockall score in predicting outcomes of elderly patients with acute upper gastrointestinal bleeding.

    abstract:AIM:To validate the clinical Rockall score in predicting outcomes (rebleeding, surgery and mortality) in elderly patients with acute upper gastrointestinal bleeding (AUGIB). METHODS:A retrospective analysis was undertaken in 341 patients admitted to the emergency room and Intensive Care Unit of Xuanwu Hospital of Capi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i22.3466

    authors: Wang CY,Qin J,Wang J,Sun CY,Cao T,Zhu DD

    更新日期:2013-06-14 00:00:00

  • Inflammatory pathways in the early steps of colorectal cancer development.

    abstract::Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have b...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i29.9716

    authors: Mariani F,Sena P,Roncucci L

    更新日期:2014-08-07 00:00:00

  • Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.

    abstract:AIM:To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism. METHODS:SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in 48 male SD rats. Pancreatic hist...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i1.35

    authors: Li J,Zhou R,Bie BB,Huang N,Guo Y,Chen HY,Shi MJ,Yang J,Zhang J,Li ZF

    更新日期:2018-01-07 00:00:00

  • Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression.

    abstract:AIM:To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats. METHODS:Giving a fructose-enriched diet (FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats (150-200 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i10.2931

    authors: Abd El-Haleim EA,Bahgat AK,Saleh S

    更新日期:2016-03-14 00:00:00

  • Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: a review.

    abstract::Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases (IBD) including ulcerative co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i4.1081

    authors: Keshteli AH,Baracos VE,Madsen KL

    更新日期:2015-01-28 00:00:00

  • Determination of the upper cut-off values of serum alanine aminotransferase and aspartate aminotransferase in Chinese.

    abstract:AIM:To determine the upper cut-off values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a Northern Chinese population. METHODS:A total of 3769 subjects in Jilin Province Northeast China were stratified to determine the potential factors affecting serum ALT and AST levels. The upper cu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i8.2419

    authors: Zhang P,Wang CY,Li YX,Pan Y,Niu JQ,He SM

    更新日期:2015-02-28 00:00:00

  • Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice.

    abstract:AIM:To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice. METHODS:Microarray technology was performed on liver tissue obtained from 4 control (LacZ) and 4 transgenic mice (HBx-LacZ), 48 h after partial hepatectomy. The s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.574

    authors: Sidorkiewicz M,Jais JP,Tralhao G,Morosan S,Giannini C,Brezillon N,Soussan P,Delpuech O,Kremsdorf D

    更新日期:2008-01-28 00:00:00

  • Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis.

    abstract:AIM:To investigate the allelic and haplotypic association of reg1alpha gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1alpha polymorphisms. METHODS:We analyzed th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i44.5938

    authors: Mahurkar S,Bhaskar S,Reddy DN,Rao GV,Chandak GR

    更新日期:2007-11-28 00:00:00

  • Giant duodenal ulcers.

    abstract::Giant duodenal ulcers (GDUs) are a subset of duodenal ulcers that have historically resulted in greater morbidity than usual duodenal ulcers. Until recently, few cases had been successfully treated with medical therapy. However, the widespread use of endoscopy, the introduction of H-2 receptor blockers and proton pump...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.4995

    authors: Newton EB,Versland MR,Sepe TE

    更新日期:2008-08-28 00:00:00

  • Differential mucin phenotypes and their significance in a variation of colorectal carcinoma.

    abstract:AIM:To investigate mucin expression profiles in colorectal carcinoma (CRC) histological subtypes with regard to clinicopathologic variables and prognosis. METHODS:Mucin (MUC)2 and MUC5AC expressions were assessed by immunohistochemistry for a total of 250 CRC cases that underwent surgical resection. CRCs included 63 w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i25.3957

    authors: Imai Y,Yamagishi H,Fukuda K,Ono Y,Inoue T,Ueda Y

    更新日期:2013-07-07 00:00:00

  • A newly designed big cup nitinol stent for gastric outlet obstruction.

    abstract:AIM:To find out whether a newly designed big cup nitinol stent is suitable for treatment of patients with gastric outlet obstruction resulting from gastric cancer. METHODS:The new stent is composed of a proximal big cup segment (20 mm in length and 48-55 mm in diameter), a middle part (60 mm in length and 20 mm in dia...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i33.4206

    authors: Shi D,Liao SH,Geng JP

    更新日期:2010-09-07 00:00:00

  • Effects of 7.5% hypertonic saline on fluid balance after radical surgery for gastrointestinal carcinoma.

    abstract:AIM:To investigate the effects of 7.5% hypertonic saline on positive fluid balance and negative fluid balance, after radical surgery for gastrointestinal carcinoma. METHODS:Fifty-two patients with gastrointestinal carcinoma undergoing radical surgery were studied. The patients were assigned to receive either Ringer la...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i11.1577

    authors: Shao YS,Zhang YT,Peng KQ,Quan ZY

    更新日期:2005-03-21 00:00:00

  • Preventive treatments for recurrence after curative resection of hepatocellular carcinoma--a literature review of randomized control trials.

    abstract::To review the inhibitory effect of preventive approaches on recurrence after operation in patients with hepatocellular carcinoma (HCC), we summarized all available publications reporting randomized control trial indexed in PubMed. The treatment approaches presented above included pre-operative transcatheter arterial c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v9.i4.635

    authors: Sun HC,Tang ZY

    更新日期:2003-04-01 00:00:00

  • Intestinal perforation after combined liver-kidney transplantation for a case of congenital polycystic disease.

    abstract:AIM:To highlight the intestinal perforation (IP), an uncommon and catastrophic complication after combined liver-kidney transplantation. METHODS:Combined liver-kidney transplantation (LKTx) with left kidney excision and a cyst fenestration procedure on the right kidney were performed on a case of 46-year-old female wi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i18.2769

    authors: Peng T,Peng MH,Li LQ,Deng YL,Yang DH,Lu BY,Chen XG,Guo Y,Xiao KY,Chen B,Zhong Q,Wei MY

    更新日期:2004-09-15 00:00:00

  • Role of gut microbiota via the gut-liver-brain axis in digestive diseases.

    abstract::The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and ne...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i40.6141

    authors: Ding JH,Jin Z,Yang XX,Lou J,Shan WX,Hu YX,Du Q,Liao QS,Xie R,Xu JY

    更新日期:2020-10-28 00:00:00

  • Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury.

    abstract:AIM:To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses, assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury. METHODS:Forty-eight female Sprague-Dawley rats were randomly divided into four groups as control, model, lo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i7.897

    authors: Shi QZ,Wang LW,Zhang W,Gong ZJ

    更新日期:2010-02-21 00:00:00

  • Stents for colorectal obstruction: Past, present, and future.

    abstract::Since the development of uncovered self-expanding metal stents (SEMS) in the 1990s, endoscopic stents have evolved dramatically. Application of new materials and new designs has expanded the indications for enteral SEMS. At present, enteral stents are considered the first-line modality for palliative care, and numerou...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i2.842

    authors: Kim EJ,Kim YJ

    更新日期:2016-01-14 00:00:00

  • Liposome transfected to plasmid-encoding endostatin gene combined with radiotherapy inhibits liver cancer growth in nude mice.

    abstract:AIM:To evaluate whether intratumoral injection of liposome-endostatin complexes could enhance the antitumor efficacy of radiation therapy in human liver carcinoma (BEL7402) model. METHODS:Recombinant plasmid pcDNA3.End was transfected into human liver carcinoma cell line (BEL7402) with lipofectamine to produce conditi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i28.4439

    authors: Zheng AQ,Song XR,Yu JM,Wei L,Wang XW

    更新日期:2005-07-28 00:00:00

  • Nasogastric tube syndrome induced by an indwelling long intestinal tube.

    abstract::The nasogastric tube (NGT) has become a frequently used device to alleviate gastrointestinal symptoms. Nasogastric tube syndrome (NTS) is an uncommon but potentially life-threatening complication of an indwelling NGT. NTS is characterized by acute upper airway obstruction due to bilateral vocal cord paralysis. We repo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i15.4057

    authors: Sano N,Yamamoto M,Nagai K,Yamada K,Ohkohchi N

    更新日期:2016-04-21 00:00:00