Abstract:
:Sex differences in behavior are widespread and often caused by hormonal differences between the sexes. In addition to hormones, the composition and numbers of the sex chromosomes also affect a variety of sex differences. In humans, X-chromosome genes are implicated in neurobehavioral disorders (i.e. fragile-X, autism). To investigate the role of X-chromosome genes in social behavior, we used a mouse model that has atypical sex chromosome configurations resembling Turner (45, XO) and Klinefelter syndromes (47, XXY). We examined a number of behaviors in juvenile mice. Mice with only one copy of most X-chromosome genes, regardless of gonadal sex, were less social in dyadic interaction and social preference tasks. In the elevated plus maze, mice with one X-chromosome spent less time in the distal ends of the open arms as compared to mice with two copies of X-chromosome genes. Using qRTPCR, we noted that amygdala from female mice with one X-chromosome had higher expression levels of vasopressin (Avp) as compared to mice in the other groups. Finally, in plasma from girls with Turner syndrome we detected reduced vasopressin (AVP) concentrations as compared to control patients. These novel findings link sex chromosome genes with social behavior via concentrations of AVP in brain, adding to our understanding of sex differences in neurobehavioral disorders.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Cox KH,Quinnies KM,Eschendroeder A,Didrick PM,Eugster EA,Rissman EFdoi
10.1016/j.psyneuen.2014.10.010subject
Has Abstractpub_date
2015-01-01 00:00:00pages
271-81eissn
0306-4530issn
1873-3360pii
S0306-4530(14)00394-1journal_volume
51pub_type
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
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