Size limits of self-assembled colloidal structures made using specific interactions.

abstract：:The U1 small nuclear ribonucleoprotein particle U1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from yeast to humans. Mutations of amino acid L13 within this domain rescue the essential function of the helicase protein Prp28p. Prp28p has been implicated in unwinding the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du H,Tardiff DF,Moore MJ,Rosbash M

更新日期：2004-10-12 00:00:00

abstract：:Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Glickson JD,Schwartz IL,Havran RT,Meienhofer J,Urry DW

更新日期：1972-07-01 00:00:00

abstract：:We have measured the oxygen concentration in the body water of murine FSa and NFSa fibrosarcomas using a new method for quantitative oxygen concentration determination deep in the tissues of a living animal. The measurement uses unusually low-frequency electron paramagnetic spectroscopy sensitive to substrate 7 cm dee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern HJ,Yu C,Peric M,Barth E,Grdina DJ,Teicher BA

更新日期：1994-12-20 00:00:00

abstract：:The Lyz endolysin of bacteriophage P1 was found to cause lysis of the host without a holin. Induction of a plasmid-cloned lyz resulted in lysis, and the lytic event could be triggered prematurely by treatments that dissipate the proton-motive force. Instead of requiring a holin, export was mediated by an N-terminal tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Struck DK,Deaton J,Wang IN,Young R

更新日期：2004-04-27 00:00:00

abstract：:An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transactivation function, gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellers WR,Rodgers JW,Kaelin WG Jr

更新日期：1995-12-05 00:00:00

abstract：:Pathogenic retroviruses have evolved multiple means for evading host restriction factors such as apolipoprotein B editing complex (APOBEC3) proteins. Here, we show that murine leukemia virus (MLV) has a unique means of counteracting APOBEC3 and other cytosolic sensors of viral nucleic acid. Using virus isolated from i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stavrou S,Nitta T,Kotla S,Ha D,Nagashima K,Rein AR,Fan H,Ross SR

更新日期：2013-05-28 00:00:00

abstract：:Na+ channels in chick brain and heart have been directly compared by measuring binding of tritium-labeled saxitoxin ([3H]STX) to the two tissues under identical conditions. Maximum saturable uptake and toxin affinity were considerably less in chick heart than in chick brain, requiring the development of an assay metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogart RB,Regan LJ,Dziekan LC,Galper JB

更新日期：1983-02-01 00:00:00

abstract：:Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barkley-Levenson E,Galván A

更新日期：2014-01-28 00:00:00

abstract：:During the late summer to fall of 1987, Caribbean reef corals experienced an intense and widespread discoloration event described as bleaching. Contrary to initial predictions, most bleached corals did not die. However, energy input from zooxanthellae decreased, as estimated from: (i) delta(13)C values, a measure of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter JW,Fitt WK,Spero HJ,Rogers CS,White MW

更新日期：1989-12-01 00:00:00

abstract：:ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use conservative approaches aimed at minimizing false-positive transcription factor targets. We present a model with improve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Margolin AA,Palomero T,Sumazin P,Califano A,Ferrando AA,Stolovitzky G

更新日期：2009-01-06 00:00:00

abstract：:Recent studies have shown that the genes of the gibberellin (GA) biosynthesis pathway in the fungus Gibberella fujikuroi are organized in a cluster of at least seven genes. P450-1 is one of four cytochrome P450 monooxygenase genes in this cluster. Disruption of the P450-1 gene in the GA-producing wild-type strain IMI ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojas MC,Hedden P,Gaskin P,Tudzynski B

更新日期：2001-05-08 00:00:00

abstract：:Night-shift workers are at high risk of drowsiness-related motor vehicle crashes as a result of circadian disruption and sleep restriction. However, the impact of actual night-shift work on measures of drowsiness and driving performance while operating a real motor vehicle remains unknown. Sixteen night-shift workers ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee ML,Howard ME,Horrey WJ,Liang Y,Anderson C,Shreeve MS,O'Brien CS,Czeisler CA

更新日期：2016-01-05 00:00:00

abstract：:Chromosomal locations of members of the xenotropic-related env gene family in the mouse genome have been determined. Endonuclease restriction site polymorphisms detected by molecular hybridization were used to study the inheritance of mink cell-focus inducing and xenotropic env gene-related sequences in recombinant in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatt C,Mileham K,Haas M,Nesbitt MN,Harper ME,Simon MI

更新日期：1983-10-01 00:00:00

abstract：:The 16S rRNA genes of Pyrobaculum aerophilum and Pyrobaculum islandicum were amplified by the polymerase chain reaction, and the resulting products were sequenced directly. The two organisms are closely related by this measure (over 98% similar). However, they differ in that the (lone) 16S rRNA gene of Pyrobaculum aer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burggraf S,Larsen N,Woese CR,Stetter KO

更新日期：1993-03-15 00:00:00

abstract：:When light-grown seedlings of amaranth are transferred to total darkness, synthesis of the large subunit (LS) and small subunit (SS) of ribulose-1,5-bisphosphate carboxylase [RbuP(2)Case; 3-phospho-D-glycerate carboxylase (dimerizing), EC 4.1.1.39] is rapidly depressed. This reduction in RbuP(2)Case synthesis occurs i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry JO,Carr JP,Klessig DF

更新日期：1988-06-01 00:00:00

abstract：:The Belgrade (b) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and gastrointestinal iron absorption. The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle. Aspects of this phenotype ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleming MD,Romano MA,Su MA,Garrick LM,Garrick MD,Andrews NC

更新日期：1998-02-03 00:00:00

abstract：:Citrullinemia is an inborn error of metabolism due to deficiency of the urea cycle enzyme, argininosuccinate synthetase [L-citrulline:L-aspartate ligase (AMP-forming), EC 6.3.4.5]. The disease was first described in humans but was recently reported in dairy cattle in Australia. Here we report the nucleotide sequence o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennis JA,Healy PJ,Beaudet AL,O'Brien WE

更新日期：1989-10-01 00:00:00

abstract：:Immigration and demographic change have become highly salient in American politics, partly because of the 2016 campaign of Donald Trump. Previous research indicates that local influxes of immigrants or unfamiliar ethnic groups can generate threatened responses, but has either focused on nonelectoral outcomes or analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill SJ,Hopkins DJ,Huber GA

更新日期：2019-12-10 00:00:00

abstract：:The plant hormone abscisic acid (ABA) is produced in response to abiotic stresses and mediates stomatal closure in response to drought via recently identified ABA receptors (pyrabactin resistance/regulatory component of ABA receptor; PYR/RCAR). SLAC1 encodes a central guard cell S-type anion channel that mediates ABA-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandt B,Brodsky DE,Xue S,Negi J,Iba K,Kangasjärvi J,Ghassemian M,Stephan AB,Hu H,Schroeder JI

更新日期：2012-06-26 00:00:00

abstract：:We demonstrate the use of self-assembly for the integration of freestanding micrometer-scale components, including single-crystal, silicon field-effect transistors (FETs) and diffusion resistors, onto flexible plastic substrates. Preferential self-assembly of multiple microcomponent types onto a common platform is ach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauth SA,Parviz BA

更新日期：2006-09-19 00:00:00

abstract：:Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of the Adenomatous polyposis coli (APC) gene. In murine models of familial adenomatous polyposis, specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amos-Landgraf JM,Irving AA,Hartman C,Hunter A,Laube B,Chen X,Clipson L,Newton MA,Dove WF

更新日期：2012-02-07 00:00:00

abstract：:Understanding the mechanisms of Salmonella virulence is an important challenge. The capacity of this intracellular bacterial pathogen to cause diseases depends on the expression of virulence factors including the second type III secretion system (TTSS-2), which is used to translocate into the eukaryotic cytosol a set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henry T,Couillault C,Rockenfeller P,Boucrot E,Dumont A,Schroeder N,Hermant A,Knodler LA,Lecine P,Steele-Mortimer O,Borg JP,Gorvel JP,Méresse S

更新日期：2006-09-05 00:00:00

abstract：:13C-labeled precorrin-6x is biosynthesized by cell-free protein preparations from Pseudomonas denitrificans in separate experiments using delta-amino[5-13C]levulinic acid and the corresponding delta-amino[4-13C]- and delta-amino[3-13C]levulinic acid-labeled forms in conjunction with S-[methyl-13C]adenosylmethionine fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thibaut D,Blanche F,Debussche L,Leeper FJ,Battersby AR

更新日期：1990-11-01 00:00:00

abstract：:Biomass burning drives changes in greenhouse gases, climate-forcing aerosols, and global atmospheric chemistry. There is controversy about the magnitude and timing of changes in biomass burning emissions on millennial time scales from preindustrial to present and about the relative importance of climate change and hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicewonger MR,Aydin M,Prather MJ,Saltzman ES

更新日期：2018-12-04 00:00:00

abstract：:The image that best expresses Darwin's thinking is the tree of life. However, Darwin's human evolutionary tree lacked almost everything because only the Neanderthals were known at the time and they were considered one extreme expression of our own species. Darwin believed that the root of the human tree was very deep ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL

更新日期：2010-05-11 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:A system for studying Z-DNA formation in the Escherichia coli chromosome was developed. Prior investigations in recombinant plasmids showed that alternating (Pur-Pyr) sequences can adopt a left-handed Z-DNA conformation both in vitro and in vivo. We constructed mobile, transposon-based cassettes carrying cloned (Pur-P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lukomski S,Wells RD

更新日期：1994-10-11 00:00:00

abstract：:Examples from various plant and animal groups indicate that there has been a general increase in potential versatility of form, determined by the number and range of independently varying morphogenetic parameters, among taxa appearing at successively younger stages in the fossil record. Taxa or body plans with higher ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeij GJ

更新日期：1973-07-01 00:00:00

abstract：:Adults and older children are more likely to punish a wrongdoer for a moral transgression when the victim belongs to their group. Building on these results, in violation-of-expectation experiments (n = 198), we examined whether 2.5-year-old toddlers (Exps. 1 and 2) and 1-year-old infants (Exps. 3 and 4) would selectiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ting F,He Z,Baillargeon R

更新日期：2019-03-26 00:00:00

abstract：:Replication of the single-stranded DNA genome of geminiviruses occurs via a double-stranded intermediate that is subsequently used as a template for rolling-circle replication of the viral strand. Only one of the proteins encoded by the virus, here referred to as replication initiator protein (Rep protein), is indispe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laufs J,Traut W,Heyraud F,Matzeit V,Rogers SG,Schell J,Gronenborn B

更新日期：1995-04-25 00:00:00