Abstract:
BACKGROUND:Experimental and clinical studies have suggested that the presence of fragmented QRS complex (fQRS) is associated with various cardiovascular diseases. fQRS may predict major adverse cardiovascular events (MACE). The current meta-analysis was performed using clinical outcome studies to evaluate the role of fQRS in coronary artery disease (CAD). METHODS:A systematic search of electronic databases (Cochrane, Medline, Embase and Pubmed) from their inception to April 2014 was performed. Data were extracted from applicable articles to evaluate the prognostic value of fQRS in CAD. RESULTS:A total of 16 observational studies about fQRS and CAD (n = 3,997 patients) were identified. Compared with the non-fQRS group, MACE and mortality were significantly higher in the fQRS group -odds ratios (OR) 3.19, 95 % confidence interval (95 % CI) [2.3, 4.42], p < 0.00001; OR 2.24, 95 % CI [1.71, 2.94], p < 0.0001. Patients developed Q waves, anterior-wall myocardial infarction (MI), and low left ventricular ejection fraction (LVEF) more frequently in the fQRS group than in the non-fQRS group-OR 2.59, 95 % CI [1.76, 3.81], p < 0.00001; OR 2.43, 95 % CI [1.07, 5.52], p = 0.03; OR - 6.43, 95 % CI [- 9.11, - 3.74], p < 0.00001. CONCLUSION:Based on current evidence, fQRS was associated with increased MACE, mortality, Q waves, anterior-wall MI, and decreased LVEF in CAD. These findings show that fQRS is a reliable marker in CAD.
journal_name
Herzjournal_title
Herzauthors
Xu Y,Qiu Z,Xu Y,Bao H,Gao S,Cheng Xdoi
10.1007/s00059-014-4155-5subject
Has Abstractpub_date
2015-03-01 00:00:00pages
8-15eissn
0340-9937issn
1615-6692journal_volume
40 Suppl 1pub_type
杂志文章,meta分析,评审相关文献
HERZ文献大全abstract::Endothelial cells synthesize and metabolize vasoactive substances which are involved in the regulation of vascular tone. Among these factors, the endothelium-derived nitric oxide (NO) appears to be of major importance. Many studies observed an impairment of the generation, release, or the diffusion of endothelial NO a...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::Disorders of the autonomic nervous control mechanisms of heart rate and vascular tone may cause syncope. Notably these are carotid sinus and vasovagal syndromes. Knowledge of their aetiology is limited. Each presents cardioinhibition and vasodepression. Pacing offers benefit in cardioinhibition and the mode required i...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:In addition to the genetic complexity of hypertrophic cardiomyopathy (HCM), there must be other disease-modifying factors that contribute to its highly variable clinical and phenotypic expression. The authors aimed to investigate serum thiol/disulphide homeostasis as a proxy for oxidative stress using a nove...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-019-04853-7
更新日期:2019-12-09 00:00:00
abstract::Despite great advances in the pathophysiology and etiology of myocarditis, the clinical diagnosis of myocarditis in daily clinical practise remains challenging. Often the diagnosis was not clear because of the heterogeneity of clinical symptoms and the lack of guidelines for adequate diagnostic requirements and consec...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-3988-7
更新日期:2013-12-01 00:00:00
abstract::Although viral myocarditis has been mostly attributed to enterovirus and adenovirus infection until recently, the association with parvovirus B19 in Europe and hepatitis C virus in Asia has lately been noted. Clinical trials of antiviral agents, such as interferons, are in progress. Whereas immunosuppression with cort...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-007-3037-5
更新日期:2007-09-01 00:00:00
abstract::The case presented here is intended to raise awareness of two uncommon coronary angiographic findings in the clinical context of acute coronary syndrome. The prevalence of patients presenting with spontaneous coronary dissection as the underlying cause of an ST-elevation myocardial infarction is low. It is typically f...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-011-3522-8
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:Endothelial dysfunction is involved in various aspects of vascular biology and different stages of cardiovascular diseases (CVDs). Nucleotide-binding oligomerization domain-containing protein (NOD) 2, a pivotal innate immune receptor for muramyl dipeptide (MDP), has been reported to be a central regulator in...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-020-04996-y
更新日期:2020-11-27 00:00:00
abstract::Cardiac surgery in patients with chronic pulmonary diseases carries a high risk of postoperative pulmonary complications (ppc) because both are known to cause ppc. Autopsy studies have revealed ppc as the main cause of mortality in approximately 5-8% of patients after cardiac surgery. Not all pulmonary diseases are hi...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-4034-5
更新日期:2014-02-01 00:00:00
abstract::Cardiovascular diseases are the leading cause of death worldwide. Adherence to a healthy lifestyle lifelong is capable of significantly reducing the cardiovascular risk by up to 70% and is therefore a key component in primary prevention of cardiovascular disease. According to the European and American guidelines lifes...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-019-04886-y
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Culture-negative endocarditis is a diagnostic challenge with variable clinical presentation and protean manifestations. ETIOLOGY AND DIAGNOSIS:The two main causes why endocarditis may be culture-negative are 1. antibiotic treatment prior to obtaining blood cultures, and 2. the presence of fastidious microor...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-001-2314-y
更新日期:2001-09-01 00:00:00
abstract::Sudden cardiac death and chronic heart failure are among the main contributors to persisting high mortality rates in Germany. In addition to removal of causal factors and guideline-conform pharmacological therapy, therapy with cardiac implantable electronic devices (CIED) is of undisputed importance. Subcutaneous defi...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-017-4548-3
更新日期:2017-04-01 00:00:00
abstract::Cardiac contractility modulation (CCM) is a device therapy for patients with systolic heart failure. CCM therapy applies non-excitatory signals during the absolute refractory period of the heart cycle. It influences myocardial contractility by modulating the regulation of calcium cycling. CCM therapy has been proven t...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-011-3510-z
更新日期:2011-10-01 00:00:00
abstract::The aortic valve consists of three cusps attached to the wall of the aortic root. During the cardiac cycle, the aortic root undergoes complex movements that precede and aid opening and closing of the aortic valve. The aortic valve cusps themselves form thin-walled pocket-like structures, made from specialized tissue w...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-006-2836-4
更新日期:2006-08-01 00:00:00
abstract::The tricuspid valve and the right ventricle are hemodynamically closely related. Pathological changes of the valve or of the ventricle itself and also various diseases beyond that can result in a downward spiral of mutual interference, which is of prognostic importance for the patient. The development of a functional ...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-017-4614-x
更新日期:2017-11-01 00:00:00
abstract:CASE REPORT:A 41-year-old male saw his general practitioner because of progressive atypical angina symptoms and palpitations for the last 7 years. Chest X-ray showed a mediastinal mass. Further investigation by computed tomography (CT), magnetic resonance imaging (MRI) and cardiac catheterization revealed two bronchoge...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-002-2366-7
更新日期:2002-12-01 00:00:00
abstract::Venous disease of the lower extremities comprises several common conditions such as varicose veins, superficial thrombophlebitis, deep venous thrombosis and chronic venous insufficiency. The high prevalence and increasing incidence with age of these disorders impose relevant diagnostic and therapeutic concerns. Varico...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-007-2958-3
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Contrast echocardiography has been used as a clinical method for more than 20 years. Using conventional ultrasound techniques the clinical use of contrast was limited. Now the development of "contrast specific" imaging modalities has increased the indications for contrast echocardiography. CONTRAST AGENTS:F...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-002-2371-x
更新日期:2002-05-01 00:00:00
abstract::Studies of the efficacy of molsidomine, previously performed on our service, demonstrated that a clear antianginal effect in the longterm treatment of angina pectoris could only be achieved with a regimen of the standard 2 mg dose when given six times daily. Consequently, since a mode of administration with a longer d...
journal_title:Herz
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1984-12-01 00:00:00
abstract::To provide an overview of our experience with percutaneous balloon valvuloplasty in aortic stenosis, the results obtained in 218 patients have been analyzed. During the two years of its use, the technique of the procedure has been subsequently modified with increasing balloon diameters, initially 15 mm, 18 mm and then...
journal_title:Herz
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:The Braunwald classification and TIMI (Thrombolysis In Myocardial Infarction) risk score are used to stratify cardiovascular risk in patients with unstable angina (UA). However, these scores have a limited capacity in the practice of cardiology. OBJECTIVES:This study sought to develop a new score, based on ...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-014-4141-y
更新日期:2015-03-01 00:00:00
abstract::M-mode, two-dimensional and Doppler echocardiography enable evaluation of morphologic changes in valvular structures, detection of secondary changes in cardiac chambers and left ventricular function and quantification of blood flow patterns. In mitral stenosis, with M-mode echocardiography the diagnosis can be establi...
journal_title:Herz
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::Dyspnea is one of the major clinical symptoms which patients report to general practitioners, internists, cardiologists and hospitals. In this review article we discuss the evidence of medical history, laboratory procedures and diagnostic investigations to approach patients with acute or chronic dyspnea and try to str...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-013-3800-8
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The expansion of the transcatheter aortic valve replacement (TAVR) indication towards patients with intermediate surgical risk (Ref. Society of Thoracic Surgeons, STS, score) was analyzed. The aim was to investigate if the complication rates particularly with respect to TAVR and surgical aortic valve replace...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-018-4680-8
更新日期:2019-09-01 00:00:00
abstract::Myocardial infarction (MI) as an acute and life-threatening complication of coronary heart disease is one of the most frequent causes of death in Germany. Therefore, diagnosis, risk stratification and treatment of acute MI are of great clinical relevance. Specific recommendations concerning diagnosis of acute MI can b...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-008-3103-7
更新日期:2008-03-01 00:00:00
abstract::In the clinical management of patients with valvular heart disease, transthoracic echocardiography (TTE) combined with Doppler has become the central diagnostic tool during the past decades. The development of transesophageal echocardiography (TEE) has led to an improved image quality especially of structures distant ...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1993-12-01 00:00:00
abstract::This review summarizes the present knowledge concerning the hemodynamic and myocardial effects of various pacing modalities with special reference to the importance of heart rate variability and atrioventricular synchronization. An adequate increase in heart rate, irrespective of atrioventricular synchronization, seem...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Saphenous vein graft disease (SVGD) after by-pass surgery is an important cause of morbidity and mortality for patients with coronary artery disease. Comprehensive evaluation of biochemical and hematological parameters associated with this problem is limited. Plateletcrit (PCT) provides complete information ...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-3798-y
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Cardiac involvement may precede the onset of muscular manifestations in Becker muscular dystrophy (BMD), but Wolff-Parkinson-White (WPW) syndrome has not been reported as initial cardiac manifestation of BMD. CASE STUDY:In a 43-year-old, HIV-negative male, WPW syndrome was diagnosed at age 26 years upon a r...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-008-3023-6
更新日期:2008-06-01 00:00:00
abstract::New therapeutic options such as the highly active antiretroviral therapy (HAART) have significantly improved morbidity and mortality of HIV-infected patients. Consequently, age-related diseases become more manifest. In addition, HIV infection itself causes certain cardiovascular morbidity. Therefore, treatment of card...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-005-2723-4
更新日期:2005-09-01 00:00:00
abstract::The discovery of an intracardial mass in patients presents a serious diagnostic dilemma. The differential diagnosis of this condition may seem abundant, but myxomas and intracardial thrombosis are the most frequent diagnoses. A connection between pregnancy and the presence of thrombosis has been documented frequently....
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-008-3127-z
更新日期:2008-11-01 00:00:00