Abstract：
:Studies of the efficacy of molsidomine, previously performed on our service, demonstrated that a clear antianginal effect in the longterm treatment of angina pectoris could only be achieved with a regimen of the standard 2 mg dose when given six times daily. Consequently, since a mode of administration with a longer duration of action was implicitly desirable, the present study, carried out in eleven patients with coronary artery disease and stable, exertional angina pectoris, was undertaken to assess the antiischemic effects of 8 mg molsidomine in sustained-release form as compared with the standard 2 mg formulation according to a double-blind, randomized, crossover, placebo-controlled protocol. Additionally, plasma concentrations of molsidomine were determined to elucidate the bioavailability as well as possible correlations between plasma concentrations and antiischemic effect. As compared with placebo, after administration of 8 mg molsidomine sustained-release there were reduction in the ST-segment depression at one, three, five and eight hours of 74% (p less than 0.001), 61% (p less than 0.001), 44% (p less than 0.025), and 31% (p less than 0.01), respectively; after 2 mg molsidomine, 74% (p less than 0.001), 37% (p less than 0.025), 7% (ns) and 6% (ns), respectively. Analysis of the response of the ST-segment in the individual patients showed an unequivocal antiischemic effect with a reduction in ST-segment depression of at least 1 mm after 8 mg molsidomine sustained-release at the specified points in time in ten, five, six and four patients, respectively, and after 2 mg molsidomine in nine, five, one and no patients, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Herzjournal_title
Herzauthors
Blasini R,Brügmann U,Rudolph Wsubject
Has Abstractpub_date
1984-12-01 00:00:00pages
346-52issue
6eissn
0340-9937issn
1615-6692journal_volume
9pub_type
临床试验,杂志文章,随机对照试验相关文献
HERZ文献大全abstract：:Echocardiographic studies and radiological measurements of heart volume were performed in 30 female track athletes, 17 female shot-putters or javelin throwers, 12 nonathletic women and 8 female patients with arterial hypertension. The following observations were made: The hearts of the female athletes undergoing endur...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
abstract：UNLABELLED:Due to the increasing number of elderly as well as chronically-ill patients, venous thrombosis assumes an increasing role as a typical complication of many courses of disease. Postoperatively, in patients without anticoagulation, fibrinogen tests show venous thrombosis in the lower extremities in up to 50% b...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1989-12-01 00:00:00
abstract：:Henoch-Schönlein purpura (HSP) is characterized by vasculitic involvement of small-sized vessels and results in multisystem manifestations. Cardiac involvement is extremely rare and myocardial infarction with coronary thrombus formation in those patients has also rarely been reported. Herein, we report a 33-year-old m...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-012-3597-x
更新日期：2012-11-01 00:00:00
abstract：:Despite great advances in the pathophysiology and etiology of myocarditis, the clinical diagnosis of myocarditis in daily clinical practise remains challenging. Often the diagnosis was not clear because of the heterogeneity of clinical symptoms and the lack of guidelines for adequate diagnostic requirements and consec...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-013-3988-7
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND AND AIM OF THE STUDY:The predisposition to atrial fibrillation (AF) in mitral stenosis (MS) has been demonstrated with several electrocardiographic (increased P-wave dispersion) and echocardiographic parameters (atrial electromechanical delay). Despite the improvement in P-wave dispersion after percutaneous ...
journal_title：Herz
pub_type： 临床试验,杂志文章
doi：10.1007/s00059-012-3672-3
更新日期：2013-03-01 00:00:00
abstract：:To provide an overview of our experience with percutaneous balloon valvuloplasty in aortic stenosis, the results obtained in 218 patients have been analyzed. During the two years of its use, the technique of the procedure has been subsequently modified with increasing balloon diameters, initially 15 mm, 18 mm and then...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the prognostic value of restrictive right ventricular filling pattern (RRVFP) in patients with the first acute inferior wall myocardial infarction (IWMI) complicated by right ventricular myocardial infarction (RVMI) undergoing primary percutaneous coronary interventio...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-017-4631-9
更新日期：2019-04-01 00:00:00
abstract：:The diagnosis of constrictive pericarditis should be considered in any patient with unexplained right heart failure. The differentiation between constrictive pericarditis and restrictive cardiomyopathy is based on a combination of clinical presentation, history and imaging, and on occasion, on the basis of invasive he...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-012-3663-4
更新日期：2012-09-01 00:00:00
abstract：:We present a case of severe congestive left heart failure due to profound and long-term hypocalcemia caused by surgically induced hypoparathyroidism. Hypocalcemia as a potential contributor to heart failure should be included in the differential diagnosis of all patients with congestive heart failure who do not respon...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-010-3374-7
更新日期：2010-10-01 00:00:00
abstract：:Many electrophysiological and histological investigations have demonstrated that post-operative dysrhythmias which occur in children with heart disorders requiring extensive surgical treatment in the area of the right atrium, are often caused by intraoperative lesions of the sinoatrial node. Accordingly, accurate dete...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:The endothelium, the monolayer covering the inner surface of blood vessels, plays a pivotal role in the regulation of vascular tone and structure, as well as vascular inflammation and thrombosis, i.e., of key events of the atherosclerotic disease process and its clinical complications, such as myocardial infarction an...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/s00059-007-3073-1
更新日期：2007-10-01 00:00:00
abstract：:From April 1973 through March 1978, 34 patients with univentricular heart and outlet chamber underwent repair by septation of the ventricle. Three had normally related great arteries in which the pulmonary artery arose from the outlet chamber. Six patients had an anterior aorta arising from an anterior or right-sided ...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:Despite all advances in the diagnostic and therapy of cardiovascular diseases the mortality from malignant ventricular tachyarrhythmias is still a major health problem. In addition to established therapeutic strategies in the prevention of sudden cardiac death such as antiarrhythmic drug treatment, catheter ablation o...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:Left ventricular function was assessed in 38 patients two to six days after acute myocardial infarction using nuclear angiocardiography and the following parameters were measured: Left ventricular end-diastolic (LVEDV) and end-systolic volumes (LVESV), ejection fraction (LVEF), indices of left ventricular filling and ...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:For more than two centuries digitalis has been used in the treatment of cardiac disease. Despite this long clinical experience with the drug, controversy still exists as to its clinical effect and impact on survival, especially in patients after myocardial infarction. In the last decade a number of studies have addres...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1993-04-01 00:00:00
abstract：:Based on the epidemiologic data of the Framingham heart study, arterial hypertension and coronary artery disease are the most frequent etiologic factors for the development of heart failure. In the pressure overloaded heart, hypertrophic growth of the myocardium includes the enlargement of cardiac myocytes stimulated ...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:The polymer-free biolimus-A9 drug-coated stent (DCS) was reported to have superior safety and efficacy outcomes compared with a bare metal stent in the LEADERS FREE trial of high-bleeding-risk patients with acute coronary syndrome and on dual antiplatelet treatment (DAPT) for 1 month. The aim of this investi...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-018-4701-7
更新日期：2019-12-01 00:00:00
abstract：:One of the most important problems in clinical cardiology is still unresolved, i.e., the development of a restenosis following coronary balloon angioplasty. Our knowledge about the sequelae of pathophysiologic events occurring during neointima formation is still far from complete (Figure 1) and numerous therapeutic tr...
journal_title：Herz
pub_type： 杂志文章,评审
doi：10.1007/BF03044285
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVES:Endothelial dysfunction is involved in various aspects of vascular biology and different stages of cardiovascular diseases (CVDs). Nucleotide-binding oligomerization domain-containing protein (NOD) 2, a pivotal innate immune receptor for muramyl dipeptide (MDP), has been reported to be a central regulator in...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-020-04996-y
更新日期：2020-11-27 00:00:00
abstract：:We report the case of a patient with both a left bundle branch block-preexcited tachycardia using a Mahaim bundle and a tachycardia exhibiting a left bundle branch pattern without preexcited complexes related to an AV nodal reentrant tachycardia. Successful ablation of the nodoventricular tract was obtained in the pos...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Upon coincubation with platelet aggregates, CD34(+) progenitor cells have the potential to differentiate into foam cells. There is evidence that progenitor cells from diabetic and nondiabetic patients have different properties, which may affect the patients' prognosis. In this study we investigated an in vit...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-013-4012-y
更新日期：2015-05-01 00:00:00
abstract：:We examined the relationships between spontaneous heart rate (or conversely cycle length) changes and left ventricular diastolic dimensions and indices of systolic function in twenty-three subjects. In most there was clearly an inverse relationship between rate and these indices and nearly always a positive correlatio...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:47 patients with aortic valve disease were studied by left ventricular micromanometry and cineangiography before and 18 months after successful valve replacement. There were 27 patients (17 with aortic stenosis, ten with aortic insufficiency) with moderate hypertrophy (angiographic mass less than 180 g/m2) and 20 pati...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:While there is general agreement on the favorable impact of immunosuppression in eosinophilic, granulomatous, giant cell and lymphocytic myocarditis and with inflammatory myocardial disease associated with connective tissue disorders or with rejection of a transplanted heart, its therapeutic role in the treatment of l...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-012-3694-x
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the clinical and imaging features of patients with cardiac rhabdomyomas associated with tuberous sclerosis complex. PATIENTS AND METHODS:The clinical and imaging characteristics of seven patients with cardiac rhabdomyomas associated with tuberous sclerosis complex between ...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-014-4078-1
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Fragmented QRS complexes (fQRS) have been associated with increased morbidity and mortality, sudden cardiac death, and recurrent cardiovascular events. The association between left ventricular systolic and diastolic functions and presence of fragmented QRS has not been comprehensively studied to date. We tes...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-012-3739-1
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:The differential diagnosis of pericardial effusion is often challenging because different etiologies can be discussed. Of particular therapeutic and prognostic importance is the definitive differentiation of malignant pericardial effusion from benign effusions. The definitive diagnosis of malignant pericardi...
journal_title：Herz
pub_type： 杂志文章
doi：10.1007/s00059-011-3451-6
更新日期：2011-06-01 00:00:00
abstract：:One of the most important treatment principles in interventional cardiology relies on myocardial revascularization by percutaneous coronary intervention (PCI) or surgical placement of coronary artery bypass grafts (CABG). However, in order to apply these principles effectively, it is important to identify patients who...
journal_title：Herz
pub_type： 杂志文章,实务指引
doi：10.1007/s00059-014-4180-4
更新日期：2014-12-01 00:00:00
abstract：:Plasma catecholamines and hemodynamic were assessed in 32 patients with heart failure of varying degrees due to coronary artery disease as well as in twelve healthy control subjects. The studies employed the use of a (Swan-Ganz) semi-floating, balloon-tipped, thermodilution catheter during supine bicycle ergometry at ...
journal_title：Herz
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:Stress echocardiography has come a long way in the past ten to twelve years since it first began. There have been many procedural and technical advances. The results being obtained by those laboratories with active programs are very gratifying. Stress echocardiography is proving to be particularly valuable in women an...
journal_title：Herz
pub_type： 杂志文章,评审
doi：
更新日期：1991-10-01 00:00:00
