Abstract:
:While there is general agreement on the favorable impact of immunosuppression in eosinophilic, granulomatous, giant cell and lymphocytic myocarditis and with inflammatory myocardial disease associated with connective tissue disorders or with rejection of a transplanted heart, its therapeutic role in the treatment of lymphocytic inflammatory cardiomyopathy (ICM) is still debated. Previous retrospective studies reported a relevant (≥ 10% left ventricular ejection fraction) clinical benefit in 90% of patients with virus-negative ICM and no cardiac impairment in 85% of patients with virus-positive ICM following immunosuppression. Some studies identified cardiomyocyte HLA up-regulation as an additional indicator of ICM susceptibility to immunosuppressive therapy. Recently in a single-center randomized prospective double-blind trial using a combination of prednisone (1 mg/kg per day for 4 weeks followed by 0.33 mg/kg per day for 5 months) and azathioprine (2 mg/kg per day for 6 months) in addition to supportive treatment in 85 virus-negative ICM patients, a significant improvement of left ventricular ejection fraction and a significant reduction of left ventricular dimensions in 88% of 43 treated patients was reported when compared to 42 patients receiving placebo who showed a cardiac impairment initially in 83% of cases (TIMIC study). These data confirm the efficacy of immunosuppression in virus-negative ICM. The lack of response in 12% of cases suggests that the missing response might be due to the presence of viruses which were not screened for or to mechanisms of damage and inflammation not susceptible to immunosuppression. The recovery of cardiac function in responders to immunosuppression was associated with the inhibition of cardiomyocyte death, an increase of cell proliferation and with newly synthesized contractile material.
journal_name
Herzjournal_title
Herzauthors
Frustaci A,Chimenti Cdoi
10.1007/s00059-012-3694-xsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
854-8issue
8eissn
0340-9937issn
1615-6692journal_volume
37pub_type
杂志文章相关文献
HERZ文献大全abstract::Catheter ablation for ventricular fibrillation in structurally normal hearts is in its infancy. Recently, catheter ablation of idiopathic ventricular fibrillation as well as ventricular fibrillation associated with the long QT and Brugada syndromes has been described. This review article is a summary of our current un...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-003-2491-y
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Culture-negative endocarditis is a diagnostic challenge with variable clinical presentation and protean manifestations. ETIOLOGY AND DIAGNOSIS:The two main causes why endocarditis may be culture-negative are 1. antibiotic treatment prior to obtaining blood cultures, and 2. the presence of fastidious microor...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-001-2314-y
更新日期:2001-09-01 00:00:00
abstract::MR with its various imaging protocols including spin-echo MR-imaging, gradient MR imaging, flow-mapping and MR angiography is the ideal tool for noninvasive assessment of any kind of aortic diseases. The technique allows to image the aorta both in the thoracic cage and in the abdominal aspects better than any other to...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s000590050026
更新日期:2000-06-01 00:00:00
abstract::The success of percutaneous transluminal coronary angioplasty (PTCA) is limited by vessel dissection with subsequent vessel occlusion in the acute phase and by restenosis chronically. The implantation of intracoronary stents allows to manage acute complications more efficiently and reduce restenosis rate. Anticoagulat...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1996-02-01 00:00:00
abstract::Disorders of the autonomic nervous control mechanisms of heart rate and vascular tone may cause syncope. Notably these are carotid sinus and vasovagal syndromes. Knowledge of their aetiology is limited. Each presents cardioinhibition and vasodepression. Pacing offers benefit in cardioinhibition and the mode required i...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Serum cholesterol is positively associated with the risk of developing coronary heart disease. The aim of this study was to determine the relation between response of coronary arteries to ergonovine provocation and lipid profile in patients with nonsignificant coronary artery disease. PATIENTS A...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-007-2831-4
更新日期:2007-06-01 00:00:00
abstract::The aortic valve consists of three cusps attached to the wall of the aortic root. During the cardiac cycle, the aortic root undergoes complex movements that precede and aid opening and closing of the aortic valve. The aortic valve cusps themselves form thin-walled pocket-like structures, made from specialized tissue w...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-006-2836-4
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Cardiac involvement in Lyme disease, caused by the tick-borne spirochete Borrelia burgdorferi, has been reported to occur in 0.3-4 % of infected patients in Europe. Cardiac manifestations may include conduction disturbances, and also myocarditis, pericarditis, and left ventricular dysfunction. We investigate...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-014-4118-x
更新日期:2015-03-01 00:00:00
abstract::With increasing age valvular heart disease is among the most frequent diseases of the heart. Relevant valvular disease impairs not only the long-term prognosis but also physical resilience, activities of daily living and the quality of life. In cases of middle to high-grade symptomatic cardiac defects, valve replaceme...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-020-04915-1
更新日期:2020-04-20 00:00:00
abstract::Based on the epidemiologic data of the Framingham heart study, arterial hypertension and coronary artery disease are the most frequent etiologic factors for the development of heart failure. In the pressure overloaded heart, hypertrophic growth of the myocardium includes the enlargement of cardiac myocytes stimulated ...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:In Germany, about 6,000 pregnancies in women with grown-up congenital heart disease or acquired valvular lesions are expected per year. The pregnancy-related physiology is characterized by a 50% increase in plasma volume and a 25% increase in erythrocyte volume. The cardiac output increases by 40% due to 30%...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-003-2467-y
更新日期:2003-05-01 00:00:00
abstract::Although rarely reported, acute instent thrombosis can be life threatening, especially in cases where there are no ST segment changes. For this reason, careful history taking, follow-up, and prompt coronary angiography may be lifesaving. Herein, a case of acute stent thrombosis with no ST segment changes on electrocar...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-011-3526-4
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Short-term prognosis of patients with chest pain and angiographically smooth coronary arteries is good in terms of development of coronary events (fatal or nonfatal myocardial infarction, coronary death, new coronary heart disease), but long-term studies are rare. PATIENTS AND METHODS:185 consecutive patien...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-003-2295-0
更新日期:2003-08-01 00:00:00
abstract::Primary tumors of the great vessels are very rare. Primary leiomyosarcomas of the pulmonary vein are extremely rare and little is known about their clinical manifestation and treatment. We report the case of a 34-year-old patient with primary leiomyosarcoma of the pulmonary vein extending into the left atrium. A revie...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-3833-z
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Cardiac involvement may precede the onset of muscular manifestations in Becker muscular dystrophy (BMD), but Wolff-Parkinson-White (WPW) syndrome has not been reported as initial cardiac manifestation of BMD. CASE STUDY:In a 43-year-old, HIV-negative male, WPW syndrome was diagnosed at age 26 years upon a r...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-008-3023-6
更新日期:2008-06-01 00:00:00
abstract::Obstructive pulmonary vascular disease and pulmonary hypertension are facts daily encountered by pediatric cardiologists. However longterm thromboembolism, pulmonary vascular obstruction and cor pulmonale are rare conditions in children. The case report of a four years old child treated by a Pudenz ventriculo venous s...
journal_title:Herz
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract:OBJECTIVES:Little is known about cardiac involvement in m.3243A>G variant carriers. Thus, this study aimed to assess type and frequency of cardiac disease in symptomatic and asymptomatic m.3243A>G carriers. METHODS:Systematic literature review. RESULTS:The m.3243A>G variant may manifest phenotypically as mitochondria...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-018-4739-6
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Left ventricular filling pressure (LVFP) is raised by the compromised contraction and impaired ventricular compliance in dilated hearts with systolic dysfunction. Timely recognition and staging of this condition are important for planning of the treatment strategy and making the prognosis. Two-dimensional sp...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-3817-z
更新日期:2014-03-01 00:00:00
abstract::Management of acute ST elevation myocardial infarction (STEMI) demands rapid and complete reperfusion of the infarct-related artery (IRA). With postinfarction prognosis depending on time delay from onset of symptoms to complete reperfusion (TIMI 3 flow) of the IRA, primary percutaneous coronary intervention (PPCI) per...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-007-3061-5
更新日期:2007-12-01 00:00:00
abstract::This review summarizes the present knowledge concerning the hemodynamic and myocardial effects of various pacing modalities with special reference to the importance of heart rate variability and atrioventricular synchronization. An adequate increase in heart rate, irrespective of atrioventricular synchronization, seem...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) dysfunction that predominantly affects older women and has three main variants: apical, mid-ventricular, and basal. The recurrence rate of TTC is roughly around 11 % at 4-year follow-up. The pathogenesis of TTC is not clear and various theor...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-013-3896-x
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:It is not known whether older patients with acute heart failure (HF) receiving tolvaptan have decreased mortality rates and a better long-term prognosis than patients who receive furosemide. We conducted a systematic review of randomized controlled trials (RCTs) to address this issue. METHODS:The Medline, E...
journal_title:Herz
pub_type: 杂志文章,meta分析
doi:10.1007/s00059-017-4563-4
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS) single-nucleotide polymorphisms have been reported to confer susceptibility to hypertension, but no consensus has been reached. The aim of this study was to investigate the association between iNOS and hypertension in a Chinese population. METHODS:This was a case-contr...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-017-4591-0
更新日期:2018-08-01 00:00:00
abstract::From April 1973 through March 1978, 34 patients with univentricular heart and outlet chamber underwent repair by septation of the ventricle. Three had normally related great arteries in which the pulmonary artery arose from the outlet chamber. Six patients had an anterior aorta arising from an anterior or right-sided ...
journal_title:Herz
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract::To account for the current evidence in the field of infective endocarditis and to harmonize deviant national guidelines, in 2009 the European Society of Cardiology published novel recommendations on the prevention, diagnosis and treatment of infective endocarditis.The most important changes can be found concerning ant...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-010-3403-6
更新日期:2010-12-01 00:00:00
abstract::In the past decade, thrombolytic therapy has become standard treatment of acute myocardial infarction. When the importance of thrombosis in the pathogenesis of acute infarction was fully recognised, several plasminogen activators were developed, streptokinase, urokinase, recombinant tissue-type plasminogen activator (...
journal_title:Herz
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::Implantable defibrillators (ICDs) have to be replaced after 4-6 years due to battery depletion. Therefore, 195-267 ICDs may be necessary for 100 ICD patients, if device longevity is 6 and 4 years, respectively. In Germany, 35% of all ICDs were replacements in 2003. The percentage of replacements will probably increase...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-005-2744-z
更新日期:2005-11-01 00:00:00
abstract::Familial dilated cardiomyopathy (F-DCM) describes a clinically and genetically heterogeneous group of diseases, mostly inherited as autosomal dominant traits, having idiopathic left ventricular dilatation and dysfunction as a common phenotype. The age of onset, rate of progression, disease complications, as well as ov...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-012-3707-9
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Limited data exist on bioresorbable scaffolds (BRS) in patients with acute coronary syndrome (ACS). The aim of the present study was to evaluate novolimus-eluting BRS (DESolve) as interventional treatment for patients with ACS, and to compare its 12-month outcomes with the everolimus-eluting bioresorbable sc...
journal_title:Herz
pub_type: 杂志文章
doi:10.1007/s00059-019-4822-7
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that circulating progenitor cells contribute to the formation of new blood vessels in adults after tissue ischemia. The infusion of these progenitor cells was used as a therapeutic approach to increase vascularization. In several animal models, progenitor cells improved vascularization...
journal_title:Herz
pub_type: 杂志文章,评审
doi:10.1007/s00059-002-2427-y
更新日期:2002-11-01 00:00:00