Abstract：
:Although viral myocarditis has been mostly attributed to enterovirus and adenovirus infection until recently, the association with parvovirus B19 in Europe and hepatitis C virus in Asia has lately been noted. Clinical trials of antiviral agents, such as interferons, are in progress. Whereas immunosuppression with corticosteroids or cyclosporine is ineffective, immunosuppressors that do not promote viral replication, such as FTY720, are promising new approaches. The inhibition of nuclear factor-kappaB and angiotensin II effectively suppresses inflammation in experimental viral myocarditis. In the EMCV animal model Pycnogenol inhibits viral replication, suppresses the expression of pro-inflammatory cytokines and mast cell-related mediators, and improves inflammation and myocardial necrosis. Pimobendan, FTY720 and Pycnogenol are promising agents for the treatment of viral myocarditis.
journal_name
Herzjournal_title
Herzauthors
Matsumori Adoi
10.1007/s00059-007-3037-5subject
Has Abstractpub_date
2007-09-01 00:00:00pages
452-6issue
6eissn
0340-9937issn
1615-6692journal_volume
32pub_type
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