The role of sex and sex-related hormones in cognition, mood and well-being in older men and women.

Abstract:

:Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

Castanho TC,Moreira PS,Portugal-Nunes C,Novais A,Costa PS,Palha JA,Sousa N,Santos NC

doi

10.1016/j.biopsycho.2014.08.015

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

158-66

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(14)00193-8

journal_volume

103

pub_type

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