Abstract:
:Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.
journal_name
Biol Psycholjournal_title
Biological psychologyauthors
Castanho TC,Moreira PS,Portugal-Nunes C,Novais A,Costa PS,Palha JA,Sousa N,Santos NCdoi
10.1016/j.biopsycho.2014.08.015subject
Has Abstractpub_date
2014-12-01 00:00:00pages
158-66eissn
0301-0511issn
1873-6246pii
S0301-0511(14)00193-8journal_volume
103pub_type
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