Brainstem involvement in obsessive-compulsive disorder.

Abstract:

:We investigated the possible involvement of the brainstem in the pathology of obsessive-compulsive disorder. Brainstem auditory evoked potentials (BAEPs) were collected from a population of neurotics (100 patients), including a group of 50 subjects suffering from obsessive-compulsive disorder (OCD) and the rest having generalized anxiety disorder. Twenty-five, age- and sex-matched, healthy volunteers served as controls. BAEPs were recorded by standard techniques as recommended by the AEEGS Clinical Evoked Potentials Guidelines. A one-way analysis of variance and the Fisher least-significant difference test were used for statistical analysis of the data. After stimulation of the right ear, a significant increase of wave I-V interpeak latency was found in the two groups of patients as compared with that of controls. Moreover OCD patients had a significantly reduced amplitude of wave III when compared to that of the control group. Our electrophysiological data suggest a possible involvement of brainstem in OCD pathogenesis. We discuss our findings in relation to biochemical, anatomical and physiological alterations described in the literature for serotonin-dependent systems.

journal_name

Biol Psychol

journal_title

Biological psychology

authors

Nolfe G,Serra FP,Palma V,Buscaino GA

doi

10.1016/s0301-0511(97)00032-x

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

69-77

issue

1

eissn

0301-0511

issn

1873-6246

pii

S0301-0511(97)00032-X

journal_volume

48

pub_type

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