Abstract:
:We investigated the possible involvement of the brainstem in the pathology of obsessive-compulsive disorder. Brainstem auditory evoked potentials (BAEPs) were collected from a population of neurotics (100 patients), including a group of 50 subjects suffering from obsessive-compulsive disorder (OCD) and the rest having generalized anxiety disorder. Twenty-five, age- and sex-matched, healthy volunteers served as controls. BAEPs were recorded by standard techniques as recommended by the AEEGS Clinical Evoked Potentials Guidelines. A one-way analysis of variance and the Fisher least-significant difference test were used for statistical analysis of the data. After stimulation of the right ear, a significant increase of wave I-V interpeak latency was found in the two groups of patients as compared with that of controls. Moreover OCD patients had a significantly reduced amplitude of wave III when compared to that of the control group. Our electrophysiological data suggest a possible involvement of brainstem in OCD pathogenesis. We discuss our findings in relation to biochemical, anatomical and physiological alterations described in the literature for serotonin-dependent systems.
journal_name
Biol Psycholjournal_title
Biological psychologyauthors
Nolfe G,Serra FP,Palma V,Buscaino GAdoi
10.1016/s0301-0511(97)00032-xsubject
Has Abstractpub_date
1998-05-01 00:00:00pages
69-77issue
1eissn
0301-0511issn
1873-6246pii
S0301-0511(97)00032-Xjournal_volume
48pub_type
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journal_title:Biological psychology
pub_type: 杂志文章
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journal_title:Biological psychology
pub_type: 杂志文章
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2012.03.005
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Biological psychology
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pub_type: 杂志文章,评审
doi:10.1016/s0301-0511(00)00053-3
更新日期:2000-10-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章,评审
doi:10.1016/j.biopsycho.2009.03.010
更新日期:2009-07-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2010.10.009
更新日期:2011-01-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2015.03.008
更新日期:2015-05-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2015.12.009
更新日期:2016-02-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2015.02.003
更新日期:2015-04-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2012.11.019
更新日期:2013-02-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/s0301-0511(97)05249-6
更新日期:1997-08-22 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2014.11.017
更新日期:2015-03-01 00:00:00
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更新日期:2001-06-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章,随机对照试验
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更新日期:2014-01-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2014.11.003
更新日期:2015-01-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2009.09.006
更新日期:2010-01-01 00:00:00
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journal_title:Biological psychology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0301-0511(94)90049-3
更新日期:1994-09-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2015.03.016
更新日期:2015-07-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.biopsycho.2014.12.002
更新日期:2015-01-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/j.biopsycho.2017.08.055
更新日期:2017-10-01 00:00:00
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journal_title:Biological psychology
pub_type: 杂志文章
doi:10.1016/0301-0511(87)90100-1
更新日期:1987-02-01 00:00:00