Abstract:
:Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness, fatigability, and autoantibodies against protein antigens of the muscle endplate. Antibodies against acetylcholine receptor (AChR), and less frequently against muscle-Specific Kinase (MuSK) or lipoprotein related protein 4 (LRP4) occur in patients with seropositive MG (SPMG). However, about 10% of patients do not have detectable autoantibodies despite evidence suggesting that the disorder is immune mediated; this disorder is known as seronegative MG (SNMG). Using a protein array approach we identified cortactin (a protein that acts downstream from agrin/MuSK promoting AChR clustering) as potential new target antigen in SNMG. We set up an ELISA assay and screened sera from patients with SPMG, SNMG, other autoimmune diseases and controls. Results were validated by immunoblot. We found that 19.7% of patients with SNMG had antibodies against cortactin whereas only 4.8% of patients with SPMG were positive. Cortactin antibodies were also found in 12.5% of patients with other autoimmune disorders but only in 5.2% of healthy controls. We conclude that the finding of cortactin antibodies in patients with SNMG, suggests an underlying autoimmune mechanism, supporting the use of immune therapy.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Gallardo E,Martínez-Hernández E,Titulaer MJ,Huijbers MG,Martínez MA,Ramos A,Querol L,Díaz-Manera J,Rojas-García R,Hayworth CR,Verschuuren JJ,Balice-Gordon R,Dalmau J,Illa Idoi
10.1016/j.autrev.2014.08.039subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1003-7issue
10eissn
1568-9972issn
1873-0183pii
S1568-9972(14)00183-9journal_volume
13pub_type
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journal_title:Autoimmunity reviews
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 社论
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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