Abstract：
:Autotaxin (ATX) is a 125-kD type II ectonucleotide pyrophosphatase/phosphodiesterase (ENPP2 or NPP2) originally discovered as an unknown "autocrine motility factor" in human melanoma cells. In addition to its pyrophosphatase/phosphodiesterase activities ATX has lysophospholipase D (lysoPLD) activity, catalyzing the conversion of lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). ATX is the only ENPP family member with lysoPLD activity and it produces most of the LPA in circulation. In support of this, ATX heterozygous mice have 50% of normal LPA plasma levels. The ATX-LPA signaling axis plays an important role in both normal physiology and disease pathogenesis and recently has been linked to pruritus in chronic cholestatic liver diseases, including primary biliary cholangitis (PBC). Several lines of evidence have suggested that a circulating puritogen is responsible, but the identification of the molecule has yet to be definitively identified. In contrast, plasma ATX activity is strongly associated with pruritus in PBC, suggesting a targetable molecule for treatment. We review herein the biochemistry of ATX and the rationale for its role in pruritus.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Sun Y,Zhang W,Evans JF,Floreani A,Zou Z,Nishio Y,Qi R,Leung PS,Bowlus CL,Gershwin MEdoi
10.1016/j.autrev.2016.03.019subject
Has Abstractpub_date
2016-08-01 00:00:00pages
795-800issue
8eissn
1568-9972issn
1873-0183pii
S1568-9972(16)30076-3journal_volume
15pub_type
杂志文章,评审abstract：:Raynaud's phenomenon is an episodic vasospasm of the peripheral arteries, causing pallor followed by cyanosis and redness with pain and sometimes paraesthesia, and, rarely, ulceration of the fingers and toes. Primary or idiopathic Raynaud's phenomenon (Raynaud's disease) occurs without an underlying disease. Secondary...
journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2008.07.002
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2002-08-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2011-11-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2018-07-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
doi：10.1016/j.autrev.2014.11.009
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2010-10-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
doi：10.1016/j.autrev.2006.09.011
更新日期：2007-01-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2008.01.001
更新日期：2008-05-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2012-07-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2012.02.006
更新日期：2012-09-01 00:00:00
abstract：:Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups ...
journal_title：Autoimmunity reviews
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/j.autrev.2017.07.012
更新日期：2017-09-01 00:00:00
