Abstract：
:Impaired clearance of apoptotic cell material has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Besides many other molecules, C1q and DNaseI contribute to an efficient clearance of dying cells. A frequently observed factor in SLE patients is the accumulation of unusually large amounts of apoptotic cells in various tissues. We showed that in a subgroup of patients with SLE, apoptotic cells accumulated in the germinal centers of the lymph nodes. The numbers of tingible body macrophages usually containing engulfed apoptotic nuclei were significantly reduced in these patients. Furthermore, we differentiated macrophages from CD34+ stem cells of SLE patients and NHD in vitro to analyze whether the observed clearance defects are intrinsic. Indeed, macrophages from SLE patients showed a reduced phagocytic capability. Very interestingly, those macrophages from different SLE patients, as well as granulocytes from these patients, showed in part different phagocytic defects, suggesting a heterogeneous clearance defect. We conclude that a failure of clearance in the early phase of apoptosis leads to a secondary necrotic status of the cells. Danger signals are released, modified autoantigens are accessible, and an autoimmune reaction gets started.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Gaipl US,Voll RE,Sheriff A,Franz S,Kalden JR,Herrmann Mdoi
10.1016/j.autrev.2004.10.007keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
189-94issue
4eissn
1568-9972issn
1873-0183pii
S1568-9972(04)00221-6journal_volume
4pub_type
杂志文章,评审abstract：:The pathophysiology of autoimmune diseases such as Multiple Sclerosis (MS) involves a complex interaction between genetic and environmental factors. Studies of monozygotic twins suggest a significant role for environmental factors in susceptibility to MS. Numerous studies, driven by the "Hygiene Hypothesis," have focu...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2009.11.006
更新日期：2010-03-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2009-07-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
doi：10.1016/j.autrev.2008.04.005
更新日期：2008-07-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
doi：10.1016/j.autrev.2019.102457
更新日期：2020-02-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2013.07.007
更新日期：2014-02-01 00:00:00
abstract：:New biologic agents have changed the paradigm of rheumatoid arthritis treatment, leading to improvement in managing patients' refractory to classical DMARDs. Anti-TNF-alpha is used as first-line treatment in patients failing to respond to classical DMARDs. However, up to 50% of patients fail to respond to these drugs ...
journal_title：Autoimmunity reviews
pub_type： 杂志文章
doi：10.1016/j.autrev.2009.12.010
更新日期：2010-04-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2010.03.002
更新日期：2010-06-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,多中心研究
doi：10.1016/j.autrev.2014.08.031
更新日期：2014-10-01 00:00:00
abstract：:Autoimmune diseases refer to a spectrum of diseases characterized by an active immune response against the host, which frequently involves increased autoantibody production. The pathogenesis of autoimmune diseases is multifactorial and the exploitation of novel effective treatment is urgent. Capsaicin is a nutritional...
journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2016.01.009
更新日期：2016-05-01 00:00:00
