Abstract:
:Hashimoto thyroiditis (HT), now considered the most common autoimmune disease, was described over a century ago as a pronounced lymphoid goiter affecting predominantly women. In addition to this classic form, several other clinico-pathologic entities are now included under the term HT: fibrous variant, IgG4-related variant, juvenile form, Hashitoxicosis, and painless thyroiditis (sporadic or post-partum). All forms are characterized pathologically by the infiltration of hematopoietic mononuclear cells, mainly lymphocytes, in the interstitium among the thyroid follicles, although specific features can be recognized in each variant. Thyroid cells undergo atrophy or transform into a bolder type of follicular cell rich in mitochondria called Hürthle cell. Most HT forms ultimately evolve into hypothyroidism, although at presentation patients can be euthyroid or even hyperthyroid. The diagnosis of HT relies on the demonstration of circulating antibodies to thyroid antigens (mainly thyroperoxidase and thyroglobulin) and reduced echogenicity on thyroid sonogram in a patient with proper clinical features. The treatment remains symptomatic and based on the administration of synthetic thyroid hormones to correct the hypothyroidism as needed. Surgery is performed when the goiter is large enough to cause significant compression of the surrounding cervical structures, or when some areas of the thyroid gland mimic the features of a nodule whose cytology cannot be ascertained as benign. HT remains a complex and ever expanding disease of unknown pathogenesis that awaits prevention or novel forms of treatment.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Caturegli P,De Remigis A,Rose NRdoi
10.1016/j.autrev.2014.01.007subject
Has Abstractpub_date
2014-04-01 00:00:00pages
391-7issue
4-5eissn
1568-9972issn
1873-0183pii
S1568-9972(14)00019-6journal_volume
13pub_type
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journal_title:Autoimmunity reviews
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2015.01.018
更新日期:2015-06-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2017.10.003
更新日期:2017-12-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,meta分析
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更新日期:2019-05-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2005.08.009
更新日期:2006-02-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2015.05.006
更新日期:2015-09-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 共识发展会议,杂志文章,评审
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2009-03-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2007.11.007
更新日期:2008-01-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,meta分析
doi:10.1016/j.autrev.2018.09.001
更新日期:2019-02-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-02-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.11.010
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.autrev.2017.05.011
更新日期:2017-07-01 00:00:00