Abstract：
INTRODUCTION:The upcoming of biosimilars in rheumatic diseases have generated considerable interest throughout the past five years among pharmaceutical industries and regulatory agencies, their development is associated with considerable variation and heterogeneity on the variable requirements for license and marketing throughout the various continents. AIM:In this article we reviewed the contents of the conference presented on the last XI International Conference in Autoimmunity in Lisbon. EVIDENCE:Truly biosimilars that followed requirements from stringent agencies are now available and licensed for infliximab, etanercept, adalimumab and rituximab but several compounds from the same mechanism of action are also being developed and are reviewed and the strengths of their evidence analized and discussed. The use of intended copies (biomimics) and its presence in less regulated markets are also reviewed and the risks of their use without proper monitoring is also evaluated. PLACE IN THERAPY:Biosimilars for rheumatic diseases is expected to change the access of patients to high costs biologics and gradually more and more patients are being switched to biosimilars either by the rheumatologist prescription or mandatory national indications. The economic impact is expected to be huge in the coming years. Second generation biosimilars are also being developed and clinical trials are underway for license in the near future.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Scheinberg M,Azevedo Vdoi
10.1016/j.autrev.2018.09.005subject
Has Abstractpub_date
2019-02-01 00:00:00pages
203-208issue
2eissn
1568-9972issn
1873-0183pii
S1568-9972(18)30294-5journal_volume
18pub_type
杂志文章,评审abstract：OBJECTIVE:To describe safety and efficacy of rituximab in patients with systemic sclerosis. METHODS:We included 13 patients with systemic sclerosis treated with rituximab and pooled with 40 additional patients from the literature. SSc rituximab untreated patients were matched to rituximab treated ones. RESULTS:Thirte...
journal_title：Autoimmunity reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.autrev.2017.12.010
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2013.07.007
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2009.08.006
更新日期：2009-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-03-01 00:00:00
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pub_type： 杂志文章,收录出版,评审
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更新日期：2019-07-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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