Abstract：
:Autoimmune Syndrome Induced by Adjuvant (ASIA) is a definition aimed to describe the common etiological process at the root of five clinical entities sharing similar symptomatology: macrophagic myofasciitis syndrome (MMF), Gulf War Syndrome (GWS), sick building syndrome (SBS), siliconosis, and post vaccination autoimmune phenomena. ASIA illustrates the role of environmental immune stimulating agents, or adjuvants, in the instigation of complex autoimmune reactions among individuals bearing a genetic preponderance for autoimmunity. The value of ASIA lies first in the acknowledgment it provides for patients suffering from these as yet ill-defined medical conditions. Equally important is the spotlight it sheds for further research of these poorly understood conditions sharing a common pathogenesis. In this article we elaborate on the significance of ASIA, review the current evidence in support of the syndrome, and address recent reservations raised regarding its validity.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Segal Y,Dahan S,Sharif K,Bragazzi NL,Watad A,Amital Hdoi
10.1016/j.autrev.2017.11.037subject
Has Abstractpub_date
2018-05-01 00:00:00pages
440-448issue
5eissn
1568-9972issn
1873-0183pii
S1568-9972(18)30057-0journal_volume
17pub_type
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