The role of stress in the mosaic of autoimmunity: An overlooked association.

Abstract:

:Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. The etiopathogenesis of autoimmune disease is uncertain. Genetic factors as well as environmental factors appear to interplay, leading to a cascade of events resulting in disease onset. Stress has been postulated to play a role in disease onset in the genetically susceptible patients. During the stress response, catecholamines and glucocorticoids are released from locus coeruleus and adrenal gland. These biomolecules exert control over various immune cells in the innate and adaptive arms of the immune system, thereby altering the cytokine profile released. The increase of IL-4 promotes T-helper 2 (Th2) cell differentiation, while the decrease in IL-12 and the increased IL-10 production reduce the number of T-helper 1 (Th1) cells. The relationship between stress and autoimmune diseases is intricate. Stress has been shown to be associated with disease onset, and disease exacerbations in rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, Graves' disease as well as other autoimmune conditions. In certain conditions such as psoriasis, stress has been implicated in delaying lesion clearance upon the application of standard treatment regimes. Finally, psychological therapy and cognitive behavioral therapy aimed to reduce stress levels was shown to be effective in influencing better outcomes in many autoimmune diseases. The purpose of this paper is to closer inspect the clinical evidence regarding the role of stress on influencing the various aspects of disease entities.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Sharif K,Watad A,Coplan L,Lichtbroun B,Krosser A,Lichtbroun M,Bragazzi NL,Amital H,Afek A,Shoenfeld Y

doi

10.1016/j.autrev.2018.04.005

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

967-983

issue

10

eissn

1568-9972

issn

1873-0183

pii

S1568-9972(18)30177-0

journal_volume

17

pub_type

杂志文章,评审
  • Polymerase-1 pathway activation in acute multiple sclerosis relapse.

    abstract:BACKGROUND:Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied. OB...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2018.07.006

    authors: Achiron A,Zilkha-Falb R,Feldman A,Bovim M,Rozen O,Sarova-Pinhas I,Magalashvili D,Dolev M,Menascu S,Gurevich M

    更新日期:2018-12-01 00:00:00

  • Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus.

    abstract::Dendritic cells (DCs) constitute a heterogeneous population of professional antigen presenting cells which are the initiators and key regulators for both immunity and tolerance induction. The significance and impact of DC biology in contemporary immunology and medical research is heightened by the award of the 2011 No...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2012.03.004

    authors: Chan VS,Nie YJ,Shen N,Yan S,Mok MY,Lau CS

    更新日期:2012-10-01 00:00:00

  • Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis.

    abstract::Granulomatosis with polyangiitis (GPA) is an autoimmune systemic necrotizing small-vessel vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Oto-neurological manifestations of ANCA-associated vasculitis according to PR3-ANCA positivity and MPO-ANCA positivity are usually reported...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2016.02.005

    authors: Iannella G,Greco A,Granata G,Manno A,Pasquariello B,Angeletti D,Didona D,Magliulo G

    更新日期:2016-07-01 00:00:00

  • Childhood- versus Adult-Onset Polyarteritis Nodosa Results from the French Vasculitis Study Group Registry.

    abstract:OBJECTIVE:To investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients. METHODS:cPAN patients' clinical findings at onset and outcomes were compared to those of aPAN patients from the French Vasculitis Study Group registry matched for year of enrollment and initial systemic...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2018.08.001

    authors: Iudici M,Quartier P,Pagnoux C,Merlin E,Agard C,Aouba A,Roblot P,Cohen P,Terrier B,Mouthon L,Guillevin L,Puéchal X,French Vasculitis Study Group.

    更新日期:2018-10-01 00:00:00

  • Rett syndrome: An autoimmune disease?

    abstract::Rett syndrome (RTT) is a devastating neurodevelopmental disease, previously included into the autistic spectrum disorders, affecting almost exclusively females (frequency 1:10,000). RTT leads to intellective deficit, purposeful hands use loss and late major motor impairment besides featuring breathing disorders, epile...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2016.01.011

    authors: De Felice C,Leoncini S,Signorini C,Cortelazzo A,Rovero P,Durand T,Ciccoli L,Papini AM,Hayek J

    更新日期:2016-04-01 00:00:00

  • Systemic sclerosis and exposure to heavy metals: A case control study of 100 patients and 300 controls.

    abstract:OBJECTIVE:This case control study assessed: 1) the relationship of systemic sclerosis (SSc) related to exposure to heavy metals; and 2) the risk of SSc related to occupational exposure in male and female patients. METHODS:From 2005 to 2008, 100 patients with a definite diagnosis of SSc were included in the study; 3 ag...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2017.01.004

    authors: Marie I,Gehanno JF,Bubenheim M,Duval-Modeste AB,Joly P,Dominique S,Bravard P,Noël D,Cailleux AF,Benichou J,Levesque H,Goullé JP

    更新日期:2017-03-01 00:00:00

  • Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation.

    abstract::A few scores predicting the short-term risk of mortality in Systemic sclerosis (SSc) have been reported to date. Our study aimed to create a predictive 15-year all-cause mortality score at the time of the diagnosis of SSc. The study was based on the Spanish Scleroderma Registry (RESCLE). The cohort was split up in der...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2020.102507

    authors: Rubio-Rivas M,Corbella X,Guillén-Del-Castillo A,Tolosa Vilella C,Colunga Argüelles D,Argibay A,Vargas Hitos JA,Todolí Parra JA,González-Echávarri C,Ortego-Centeno N,Trapiella Martínez L,Rodríguez Carballeira M,Marín Ballvé A,Pl

    更新日期:2020-05-01 00:00:00

  • Pulmonary manifestations in antiphospholipid syndrome.

    abstract::Pulmonary manifestations in antiphospholipid syndrome (APS) are relatively rare compared to other clinical signs of this disease. However, pulmonary microthrombosis is among the most frequent arterial complications of APS. Timely diagnosis of pulmonary manifestations is required due both to their severity and to the h...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2006.02.002

    authors: Stojanovich L

    更新日期:2006-05-01 00:00:00

  • A comprehensive analysis of treatment outcomes in patients with pemphigus vulgaris treated with rituximab.

    abstract::Approximately 500 treatment recalcitrant pemphigus vulgaris patients have been treated with rituximab. They were treated according to the lymphoma protocol (N=224) or rheumatoid arthritis protocol (RAP) (N=209) patients. Others were treated with modifications or combinations of the two. The mean duration of follow-up ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2014.12.002

    authors: Ahmed AR,Shetty S

    更新日期:2015-04-01 00:00:00

  • Prednisone in lupus nephritis: how much is enough?

    abstract:OBJECTIVE:To assess the effectiveness and safety of a protocol using medium doses of prednisone to treat lupus nephritis. METHODS:Patients receiving the 'Cruces-protocol cohort' (CPC) were paired 1:2 with patients from the 'historic cohort' (HC). The CPC received medium doses of prednisone combined with methyl-prednis...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2013.10.013

    authors: Ruiz-Irastorza G,Danza A,Perales I,Villar I,Garcia M,Delgado S,Khamashta M

    更新日期:2014-02-01 00:00:00

  • Microscopic polyangiitis: Clinical presentation.

    abstract::Microscopic polyangiitis (MPA) is a member of the family of ANCA-associated vasculitides. Its characteristic histology shows a necrotizing small vessel vasculitis with little or absent immune deposits (pauci-immune vasculitis). In Western countries MPA shows a lower prevalence than Wegener's disease, it affects more m...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2010.07.009

    authors: Villiger PM,Guillevin L

    更新日期:2010-10-01 00:00:00

  • COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?

    abstract::The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term "hyperferritinemic syndromes" and including macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. COVID-19 systemic ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2020.102573

    authors: Colafrancesco S,Alessandri C,Conti F,Priori R

    更新日期:2020-07-01 00:00:00

  • International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholip

    abstract::Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups ...

    journal_title:Autoimmunity reviews

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1016/j.autrev.2017.07.012

    authors: Giacomelli R,Afeltra A,Alunno A,Baldini C,Bartoloni-Bocci E,Berardicurti O,Carubbi F,Cauli A,Cervera R,Ciccia F,Cipriani P,Conti F,De Vita S,Di Benedetto P,Doria A,Drosos AA,Favalli EG,Gandolfo S,Gatto M,Grembiale R

    更新日期:2017-09-01 00:00:00

  • Potential off-label use of infliximab in autoimmune and non-autoimmune diseases: a review.

    abstract::TNF-alpha is a crucial cytokine in the establishment and maintenance of inflammation in multiple autoimmune and non-autoimmune disorders. A number of large placebo-controlled trials have shown that infliximab, a chimeric monoclonal antibody against TNF-alpha, is effective and well-tolerated in patients with Crohn's di...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2004.08.004

    authors: Atzeni F,Sarzi-Puttini P,Doria A,Iaccarino L,Capsoni F

    更新日期:2005-03-01 00:00:00

  • ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.

    abstract::Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions. This association is believed to be the result of defective phosphorylation of inositol 1,4,...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2012.03.006

    authors: Yeter D,Deth R

    更新日期:2012-10-01 00:00:00

  • B cells in systemic sclerosis: a possible target for therapy.

    abstract::Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix (ECM) deposition in the skin and other visceral organs and it is associated with immune activation characterized by autoantibody production, release of various cytokines and T-lymphocyte activation. Several recent lines o...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.04.013

    authors: Bosello S,De Luca G,Tolusso B,Lama G,Angelucci C,Sica G,Ferraccioli G

    更新日期:2011-08-01 00:00:00

  • B-cells and mixed cryoglobulinemia.

    abstract::Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, thro...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2007.02.019

    authors: Ferri C,Antonelli A,Mascia MT,Sebastiani M,Fallahi P,Ferrari D,Giunti M,Pileri SA,Zignego AL

    更新日期:2007-12-01 00:00:00

  • Tight control applied to the biological therapy of rheumatoid arthritis.

    abstract::In the last decade, treatment strategies for rheumatoid arthritis (RA) have included the early use of disease-modifying anti-rheumatic drugs, since prompt suppression of disease activity is associated with a reduction in radiological damage. This strategy has now been incorporated into the broader concept of "tight co...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2012.11.010

    authors: Epis OM,Giacomelli L,Deidda S,Bruschi E

    更新日期:2013-06-01 00:00:00

  • Rituximab treatment for IgA vasculitis: A systematic review.

    abstract:BACKGROUND:Immunoglobulin A vasculitis (IgAV) is a systemic small vessel vasculitis for which treatment of severe cases is usually based on glucocorticoids and other conventional immunosuppressive drugs. The role of rituximab for resistant or refractory cases has been explored in isolated case reports and small series....

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2020.102490

    authors: Hernández-Rodríguez J,Carbonell C,Mirón-Canelo JA,Diez-Ruiz S,Marcos M,Chamorro AJ

    更新日期:2020-04-01 00:00:00

  • Autoantibody-mediated atherosclerosis.

    abstract::Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by beta2-GPI and anti-beta2-GPI autoantibodies. Ligands specific for beta2-GPI derived from oxLDL have be...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1568-9972(02)00084-8

    authors: Matsuura E,Kobayashi K,Koike T,Shoenfeld Y

    更新日期:2002-12-01 00:00:00

  • B-type natriuretic peptide in rheumatic diseases: a cardiac biomarker or a sophisticated acute phase reactant?

    abstract::Natriuretic peptides (NP) are secreted by cardiomyocytes and are reliable markers of cardiac dysfunction and cardiovascular risk by reflecting myocardial stress due to various etiologies. Clinical and occult heart involvement is frequently observed in patients with rheumatic diseases and is associated with increased m...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2012.02.018

    authors: Dimitroulas T,Giannakoulas G,Karvounis H,Garyfallos A,Settas L,Kitas G

    更新日期:2012-10-01 00:00:00

  • The geoepidemiology of autoimmune muscle disease.

    abstract::Dermatomyositis (DM), polymyositis (PM), and sporadic inclusion-body myositis (sIBM) constitute a heterogeneous group of subacute or chronic acquired skeletal muscle diseases. Known as idiopathic inflammatory myopathies (IIM), they all share the presence of considerable weakness due to muscle inflammation and necrosis...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2009.11.006

    authors: Prieto S,Grau JM

    更新日期:2010-03-01 00:00:00

  • Hemopoietic stem cell transplantation in rheumatic diseases--an update.

    abstract::Hematopoietic stem cell transplant (HSCT) for autoimmune diseases has been recognized as a potential treatment for patients who have failed conventional therapy. Autologous (self) donor cells have been preferred over allogeneic (HLA-matched) cells for rescue after high dose immunotherapy, given the previous higher rat...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2005.03.003

    authors: de Buys P,Khanna D,Furst DE

    更新日期:2005-09-01 00:00:00

  • Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases.

    abstract::Heat-shock protein (Hsp) family is made up of heterogeneous proteins of which Hsp60 members are the most studied. It is now generally admitted that Hsp60 is not only a mitochondrial component but can be localized on the membrane cell surface. Considered as a signal danger following infections, Hsp60 can induce the pro...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2007.01.012

    authors: Alard JE,Dueymes M,Youinou P,Jamin C

    更新日期:2007-08-01 00:00:00

  • Sex ratio and rheumatic disease.

    abstract::Some thyroid, rheumatic and hepatic diseases consistently have high female:male ratios, but many autoimmune diseases do not. Gonadal hormones, if they play a role in determining sex ratios, likely do so through a threshold or permissive mechanism. Sex differences related to X-inactivation, imprinting, X or Y chromosom...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1568-9972(02)00034-4

    authors: Lockshin MD

    更新日期:2002-05-01 00:00:00

  • Autoantibody pain.

    abstract::As autoantibodies bind to target tissues, Fc-region dependent inflammation can induce pain via mediators exciting nociceptors. But recently another possibility has emerged, where autoantibody binding to nociceptors can directly cause pain, without inflammation. This is thought to occur as a result of Fab-region mediat...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2016.02.011

    authors: Goebel A

    更新日期:2016-06-01 00:00:00

  • Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4.

    abstract::Myasthenia gravis is caused by antibodies to the acetylcholine receptor, muscle-specific kinase, low-density lipoprotein receptor-related protein 4, or possibly yet unidentified antibodies. The mechanisms by which these antibodies interfere with the function of postsynaptic proteins include complement activation, anti...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2013.03.001

    authors: Verschuuren JJ,Huijbers MG,Plomp JJ,Niks EH,Molenaar PC,Martinez-Martinez P,Gomez AM,De Baets MH,Losen M

    更新日期:2013-07-01 00:00:00

  • Autoinflammatory diseases: how to put the fire inside the body out?

    abstract::Autoinflammatory diseases (AIDs) are a group of distinct hereditable disorders characterized by unexplained, recurrent episodes of fever and severe inflammation, most commonly involving skin, joints, gut, and eyes. Mutations in inflammasome-related proteins, particularly in NOD-like receptor (NLR) genes, have been str...

    journal_title:Autoimmunity reviews

    pub_type:

    doi:10.1016/j.autrev.2012.07.013

    authors: Doria A,Dayer JM,Punzi L

    更新日期:2012-11-01 00:00:00

  • Anti-neutrophil cytoplasmic autoantibodies: methodological aspects and clinical significance in systemic vasculitis.

    abstract::Antineutrophil cytoplasmic antibodies (ANCA) are the serological hallmark of some idiopathic systemic vasculitides, such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and, to a lesser extent, Churg-Strauss syndrome (CCS), the so-called ANCA-associated vasculitides (AAV). ANCA were first det...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2012.08.008

    authors: Radice A,Bianchi L,Sinico RA

    更新日期:2013-02-01 00:00:00

  • Treatment with etanercept in six patients with chronic hepatitis C infection and systemic autoimmune diseases.

    abstract:OBJECTIVE:To describe the clinical and immunologic features of 6 patients with rheumatic disease and Hepatitis C Virus (HCV) chronic infection, treated with anti-TNF alpha drugs. PATIENTS AND METHODS:Six patients, with repeated positive serology for HCV infection, were affected by Rheumatoid arthritis (RA) (4 cases), ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2008.05.002

    authors: Cavazzana I,Ceribelli A,Cattaneo R,Franceschini F

    更新日期:2008-12-01 00:00:00