Abstract:
:Scleroderma renal crisis (SRC) is an uncommon but still life-threatening manifestation of systemic sclerosis (SSc). The incidence of SRC has decreased in the last few decades, probably due to a widespread use of vasodilators in SSc patients. It is well-recognized that exposure to different drugs can trigger SRC (corticosteroids, cyclosporine) or might prevent its occurrence (iloprost, calcium channel blockers). The prognosis of this life-threatening manifestation has not substantially improved since 1980s, when ACE-inhibitors were introduced in its treatment. ACE-inhibitors remain the mainstay in the therapy of SRC due to their efficacy in controlling malignant hypertension; indeed, the prognosis largely depends on the rapid improvement of the ongoing renal ischemia. Calcium-channel blockers and in third line diuretics and alpha-blockers should be used as additional therapy if blood pressure control remains suboptimal despite maximum tolerated doses of ACE-inhibitors. Given the growing evidence on the role of complement activation and endothelin-1 in the pathogenesis of SRC, recent case-series and case reports have suggested the use of C5-inhibitors and endothelin receptor antagonists in the therapy of SRC, mainly in the refractory cases. Plasma-exchange seems to give some benefits in patients with SRC and microangiopathy or intolerant to ACE-inhibitors. Renal transplantation is the last treatment option and its outcome is similar to that reported in other connective tissue disorders, with a 5-year patient survival rate of about 82%. In this review we summarize the current knowledge in the treatment of SRC.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Zanatta E,Polito P,Favaro M,Larosa M,Marson P,Cozzi F,Doria Adoi
10.1016/j.autrev.2018.03.012subject
Has Abstractpub_date
2018-09-01 00:00:00pages
882-889issue
9eissn
1568-9972issn
1873-0183pii
S1568-9972(18)30157-5journal_volume
17pub_type
杂志文章,评审abstract:AIMS:Oxidation reactions can modify protein activity or specificity. Recently, a novel redox-reactive family of autoantibodies was described, which indicated involvement of altered antibodies (beside altered antigens) into autoimmune reactions. The aim of our study was to determine the binding capacity alterations of e...
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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pub_type:
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更新日期:2012-11-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1016/s1568-9972(02)00061-7
更新日期:2002-10-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.08.006
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.autrev.2020.102596
更新日期:2020-08-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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更新日期:2015-09-01 00:00:00