Abstract：
:The presence of anti-nuclear antibodies (ANA) is a hallmark of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay on HEp-2 cells is a commonly used test for the detection of ANA and was recently recommended as the screening test of choice by a task force of the American College of Rheumatology. However, up to 20% of serum samples from healthy individuals (HI) have been reported to have a positive ANA test, the majority of which are directed to the dense fine speckles 70 (DFS70) antigen. Even more important, the DFS IIF pattern has been reported in 33% of ANA positive HI, but not in ANA positive SARD sera. Since the intended use of the ANA HEp-2 test is to aid in the diagnosis of SARD, the reporting of anti-DFS70 antibodies and their associated pattern (DFS) as a positive test, significantly reduces the specificity and the positive likelihood of the ANA test. This has significant implications for diagnostic algorithms involving the detection of ANA. We summarize the current knowledge of anti-DFS70 antibodies and their impact on ANA testing. We also suggest a test algorithm which considers the DFS pattern and the presence of anti-DFS70 antibodies. In addition, we describe a novel method based on immunoadsorption of anti-DFS70 antibodies, which increases the specificity of the ANA HEp-2 test for SARD and which has the potential to overcome a significant limitation of the ANA HEp-2 assay.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Mahler M,Hanly JG,Fritzler MJdoi
10.1016/j.autrev.2011.11.005subject
Has Abstractpub_date
2012-07-01 00:00:00pages
642-5issue
9eissn
1568-9972issn
1873-0183pii
S1568-9972(11)00258-8journal_volume
11pub_type
杂志文章,评审abstract：:During pregnancy, the fetus represents a natural allograft that is not normally rejected. While the maternal immune system retains the ability to respond to foreign antigens, tolerance mechanisms are up-regulated to protect the fetus from immunologic attacks by the mother. The profound immunologic adaptations during a...
journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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pub_type： 杂志文章
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.autrev.2009.02.002
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2012.02.006
更新日期：2012-09-01 00:00:00
