Mycobacterium tuberculosis heat shock proteins and autoimmunity in sarcoidosis.

Abstract:

:Sarcoidosis (SA) is a granulomatous disorder of an unknown etiology. Infectious, genetic factors and autoimmunity have been explored as potential causes of SA. Pathologic similarities between SA and tuberculosis (TB) suggest Mycobacterium tuberculosis, especially mycobacterial antigen(s) e.g. heat shock proteins (Mtb-hsp) as causative factors. Mtb-hsp, especially Mtb-hsp65, may provide a link between infection and autoimmunity by cross-reactivity between the mycobacterial and human hsp. There is 100% homology between M.tuberculosis and Mycobacterium bovis BCG hsp. In light of evidences necessary to establish SA which is autoimmune in origin, my recently published findings prompted me to raise the hypothesis that, in genetically different individuals, the same antigens (Mtb-hsp) may induce different immune responses, leading to the development of SA or TB. The hypothesis seems to have been supported by an epidemiological analysis of the worldwide SA and TB prevalences that reveal that the TB distribution is approximately opposite to that of SA. Because one third of the Earth's population has been infected with M.tuberculosis, it is possible that the presence of mycobacterial infection or BCG vaccination (e.g., Mtb-hsp65) in genetically predisposed host may be involved in the development of autoimmunity.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Dubaniewicz A

doi

10.1016/j.autrev.2009.11.015

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

419-24

issue

6

eissn

1568-9972

issn

1873-0183

pii

S1568-9972(09)00193-1

journal_volume

9

pub_type

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