Abstract：
:Type 1 diabetes (T1D) and the autoimmune thyroid diseases (AITD) are the most common autoimmune endocrine diseases. Both are organ-specific T-cell mediated diseases. Abundant epidemiological data support a strong genetic basis for both T1D and AITD. Furthermore, both diseases commonly occur in the same individuals and in the same families. Indeed, studies suggest that the etiology of T1D and AITD may involve common genetic factors. Two immune regulatory genes, HLA and CTLA-4 contribute to the susceptibility to both diseases. Additionally, two tissue-specific genes, the insulin VNTR in T1D and Thyroglobulin in AITD play a major role in their pathogenesis. Therefore, it is likely that both immune regulatory and target tissue genes contribute to these and other autoimmune diseases.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Levin L,Tomer Ydoi
10.1016/s1568-9972(03)00080-6keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
377-86issue
6eissn
1568-9972issn
1873-0183pii
S1568997203000806journal_volume
2pub_type
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2012.03.004
更新日期：2012-10-01 00:00:00
