Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases.

Abstract:

:Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which can be isolated from various human adult tissues. In recent years, MSCs have been shown to possess broad immunoregulatory capabilities, modulating both adaptive and innate immunity. This review discusses the documented immunomodulatory capabilities of the MSCs, the possible mechanisms underlying these functions and presents the potential of using this stem cell-based approach as an immunomodulatory tool for the treatment of autoimmune diseases.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Ben-Ami E,Berrih-Aknin S,Miller A

doi

10.1016/j.autrev.2011.01.005

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

410-5

issue

7

eissn

1568-9972

issn

1873-0183

pii

S1568-9972(11)00011-5

journal_volume

10

pub_type

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