Symbolic regression of generative network models.

Abstract:

:Networks are a powerful abstraction with applicability to a variety of scientific fields. Models explaining their morphology and growth processes permit a wide range of phenomena to be more systematically analysed and understood. At the same time, creating such models is often challenging and requires insights that may be counter-intuitive. Yet there currently exists no general method to arrive at better models. We have developed an approach to automatically detect realistic decentralised network growth models from empirical data, employing a machine learning technique inspired by natural selection and defining a unified formalism to describe such models as computer programs. As the proposed method is completely general and does not assume any pre-existing models, it can be applied "out of the box" to any given network. To validate our approach empirically, we systematically rediscover pre-defined growth laws underlying several canonical network generation models and credible laws for diverse real-world networks. We were able to find programs that are simple enough to lead to an actual understanding of the mechanisms proposed, namely for a simple brain and a social network.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Menezes T,Roth C

doi

10.1038/srep06284

subject

Has Abstract

pub_date

2014-09-05 00:00:00

pages

6284

issn

2045-2322

pii

srep06284

journal_volume

4

pub_type

杂志文章
  • Chronic neural activity recorded within breast tumors.

    abstract::Nerve fibers are known to reside within malignant tumors and the greater the neuronal density the worse prognosis for the patient. Recent discoveries using tumor bearing animal models have eluded to the autonomic nervous system having a direct effect on tumor growth and metastasis. We report the first direct and chron...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71670-y

    authors: McCallum GA,Shiralkar J,Suciu D,Covarrubias G,Yu JS,Karathanasis E,Durand DM

    更新日期:2020-09-09 00:00:00

  • Postmenopausal Osteoporosis reference genes for qPCR expression assays.

    abstract::Osteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite of the efforts to clarify the relationship among genetic factors and susceptibility to develop OP, many genetic associations need to be further functionally validated. Besides, some limitations as the c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52612-9

    authors: de Lima CAD,de Lima SC,Barbosa AD,Sandrin-Garcia P,de Barros Pita W,de Azevêdo Silva J,Crovella S

    更新日期:2019-11-11 00:00:00

  • γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.

    abstract::Chronic inflammation-associated bone destruction, which is observed in rheumatoid arthritis (RA) and periodontitis, is mediated by excessive osteoclastogenesis. We showed previously that γ-glutamyltranspeptidase (GGT), an enzyme involved in glutathione metabolism, acts as an endogenous activator of such pathological o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35930

    authors: Moriwaki S,Into T,Suzuki K,Miyauchi M,Takata T,Shibayama K,Niida S

    更新日期:2016-10-24 00:00:00

  • Biomimetic matrices for rapidly forming mineralized bone tissue based on stem cell-mediated osteogenesis.

    abstract::Bone regeneration, following fracture, relies on autologous and allogenic bone grafts. However, majority of fracture population consists of older individuals with poor quality bone associated with loss and/or modification of matrix proteins critical for bone formation and mineralization. Allografts suffer from same li...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32794-4

    authors: Carvalho MS,Poundarik AA,Cabral JMS,da Silva CL,Vashishth D

    更新日期:2018-09-26 00:00:00

  • Event- and time-dependent decline of outcome information in the primate prefrontal cortex.

    abstract::The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25622

    authors: Marcos E,Tsujimoto S,Genovesio A

    更新日期:2016-05-10 00:00:00

  • Strong improvement of the transport characteristics of YBa2Cu3O7-x grain boundaries using ionic liquid gating.

    abstract::For more than 30 years, the remarkable superconducting properties of REBa2Cu3O7-x (RE = rare earth) compounds have triggered research studies across the world. Accordingly, significant progresses have been made both from a basic understanding and a fabrication processes perspective. Yet, today, the major technological...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36166-w

    authors: Fête A,Senatore C

    更新日期:2018-12-07 00:00:00

  • The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma.

    abstract::Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43681

    authors: Lau MY,Dharmage SC,Burgess JA,Win AK,Lowe AJ,Lodge C,Perret J,Hui J,Thomas PS,Morrison S,Giles GG,Hopper J,Abramson MJ,Walters EH,Matheson MC

    更新日期:2017-03-06 00:00:00

  • Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities.

    abstract::The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally occurring compound with cumulative evidence of anti-cancer properties. In this study, we assessed the chemomodulatory potential of TQ to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30046-z

    authors: Bashmail HA,Alamoudi AA,Noorwali A,Hegazy GA,AJabnoor G,Choudhry H,Al-Abd AM

    更新日期:2018-08-03 00:00:00

  • A comparative analysis using flowmeter, laser-Doppler |spectrophotometry, and indocyanine green-videoangiography for detection of vascular stenosis in free flaps.

    abstract::The effects of gradual vascular occlusion on the blood supply of perfused areas are poorly described. Information relating to the comparison of flap monitoring techniques is lacking. Varying stenotic conditions (0%, 25%, 50%, 75% and 100%) were generated on purpose at the A. and V. femoralis in the rat model. Analyses...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57777-2

    authors: Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

    更新日期:2020-01-22 00:00:00

  • Study of two G-protein coupled receptor variants of human trace amine-associated receptor 5.

    abstract::Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. A systematic detergent screen showed that fos-choline-14 was the optimal detergent to solubilize and subsequently purify the receptors. Mil...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00102

    authors: Wang X,Corin K,Rich C,Zhang S

    更新日期:2011-01-01 00:00:00

  • TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction.

    abstract::Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and fun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16683

    authors: Si Y,Chen YB,Chen SJ,Zheng YQ,Liu X,Liu Y,Jiang HL,Xu G,Li ZH,Huang QH,Xiong H,Zhang ZG

    更新日期:2015-12-07 00:00:00

  • Approach to multifunctional device platform with epitaxial graphene on transition metal oxide.

    abstract::Heterostructures consisting of two-dimensional materials have shown new physical phenomena, novel electronic and optical properties, and new device concepts not observed in bulk material systems or purely three dimensional heterostructures. These new effects originated mostly from the van der Waals interaction between...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14374

    authors: Park J,Back T,Mitchel WC,Kim SS,Elhamri S,Boeckl J,Fairchild SB,Naik R,Voevodin AA

    更新日期:2015-09-23 00:00:00

  • Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome.

    abstract::Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing Hsp90. In response to stress stimuli, Hsp90 is released, and NLRP3 can be activated to promote infl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25123-2

    authors: Piippo N,Korhonen E,Hytti M,Skottman H,Kinnunen K,Josifovska N,Petrovski G,Kaarniranta K,Kauppinen A

    更新日期:2018-04-30 00:00:00

  • Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model.

    abstract::Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent alterations in phenotype suggests stable changes in gene expression. Therefore, a genome-wide screening of the hep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20837

    authors: Willems E,Guerrero-Bosagna C,Decuypere E,Janssens S,Buyse J,Buys N,Jensen P,Everaert N

    更新日期:2016-02-10 00:00:00

  • The free-energy cost of interaction between DNA loops.

    abstract::From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12765-x

    authors: Huang L,Liu P,Yuan Z,Zhou T,Yu J

    更新日期:2017-10-03 00:00:00

  • Galewone, an Anti-Fibrotic Polyketide from Daldinia eschscholzii with an Undescribed Carbon Skeleton.

    abstract::A novel polyphenolic natural product, galewone, with undescribed carbon skeleton, was isolated as a racemate from the culture of Daldinia eschscholzii IFB-TL01, a fungus obtained from the mantis (Tenodera aridifolia) gut. The galewone structure was elucidated by a combination of MS and NMR spectra, and substantiated b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50868-9

    authors: Zhang AH,Jiang N,Wang XQ,Tan RX

    更新日期:2019-10-04 00:00:00

  • Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss.

    abstract::Behavioral alterations emerging after central or peripheral vision loss suggest that cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC). We explored the functional reorganization of the central and peripheral EVC following visual field defects specifically affecting centr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43223

    authors: Sabbah N,Sanda N,Authié CN,Mohand-Saïd S,Sahel JA,Habas C,Amedi A,Safran AB

    更新日期:2017-02-24 00:00:00

  • Nanosecond light induced, thermally tunable transient dual absorption bands in a-Ge₅As₃₀Se₆₅ thin film.

    abstract::In this article, we report the first observation of nanosecond laser induced transient dual absorption bands, one in the bandgap (TA₁) and another in the sub-bandgap (TA₂) regions of a-Ge₅As₃₀Se₆₅ thin films. Strikingly, these bands are thermally tunable and exhibit a unique contrasting characteristic: the magnitude o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06573

    authors: Khan P,Saxena T,Jain H,Adarsh KV

    更新日期:2014-10-10 00:00:00

  • Terrestrial mammalian wildlife responses to Unmanned Aerial Systems approaches.

    abstract::Unmanned Aerial Systems (UAS) are increasingly being used recreationally, commercially and for wildlife research, but very few studies have quantified terrestrial mammalian reactions to UAS approaches. We used two Vertical Take-off and Landing (VTOL) UAS to approach seven herbivore species in the Moremi Game Reserve, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38610-x

    authors: Bennitt E,Bartlam-Brooks HLA,Hubel TY,Wilson AM

    更新日期:2019-02-14 00:00:00

  • Automated pencil electrode formation platform to realize uniform and reproducible graphite electrodes on paper for microfluidic fuel cells.

    abstract::Graphite pencil stroked electrodes for paper-based Microfluidic devices are gaining immense attention due to their electrochemical properties, cost efficiency, and ease-of-use. However, their widespread use has been hindered by the challenges associated with their manual fabrication such as non-uniformity in graphite ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68579-x

    authors: Rao LT,Rewatkar P,Dubey SK,Javed A,Goel S

    更新日期:2020-07-15 00:00:00

  • Cell-penetrating peptide (CPP)-conjugated proteins is an efficient tool for manipulation of human mesenchymal stromal cells.

    abstract::Delivery of proteins has been regarded as the safest and most useful application in therapeutic application of stem cells, because proteins can regulate gene expression transiently without any genomic alteration. However, it is difficult to accurately measure efficiency or quantity of intracellular protein uptake. Her...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04378

    authors: Jo J,Hong S,Choi WY,Lee DR

    更新日期:2014-03-14 00:00:00

  • Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine.

    abstract::Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10391-1

    authors: Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

    更新日期:2017-08-29 00:00:00

  • GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic.

    abstract::GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed tha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09428-2

    authors: Kumar N,Dubey AK,Upadhyay AK,Gautam A,Ranjan R,Srikishna S,Sahu N,Behera SK,Mallick S

    更新日期:2017-08-18 00:00:00

  • Organic mulches reduce crop attack by sweetpotato weevil (Cylas formicarius).

    abstract::Mulching with organic materials is a management practice with long history for weed suppression, soil water conservation and erosion control. Its potential impact on crop pests is less well explored. Here we report its utility for reducing crop damage by the serious pest, sweetpotato weevil (Cylas formicarius). Labora...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50521-5

    authors: Rehman M,Liu J,Johnson AC,Dada TE,Gurr GM

    更新日期:2019-10-16 00:00:00

  • HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy.

    abstract::Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructura...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70297-3

    authors: Labounek R,Valošek J,Horák T,Svátková A,Bednařík P,Vojtíšek L,Horáková M,Nestrašil I,Lenglet C,Cohen-Adad J,Bednařík J,Hluštík P

    更新日期:2020-10-16 00:00:00

  • Egocentrically-stable discriminative stimulus-based spatial navigation in mice: implementation and comparison with allocentric cues.

    abstract::Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42852-0

    authors: Chun J,Kim Y,Choi JW,Kim D,Jo S

    更新日期:2019-04-23 00:00:00

  • CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy.

    abstract::Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve hMSCs survival may be of high relevance in tissue engineering. Carnitine palmitoyltransferase 1 C (CPT1C) is a pseudoenz...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25485-7

    authors: Roa-Mansergas X,Fadó R,Atari M,Mir JF,Muley H,Serra D,Casals N

    更新日期:2018-05-03 00:00:00

  • Evaluation of nutritional and elemental compositions of green and red cultivars of roselle: Hibiscus sabdariffa L.

    abstract::Roselle-Hibiscus sabdariffa L. leaves at different stages of growth, calyces and seeds were analyzed for nutritional and anti-nutritional factors. All the treatments contained a good but varied proportion of carbohydrate in a range of 26.93-54.13%, crude protein from 5.7 to 27.06%, crude fat 1.16-13.09%, crude fibre 1...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80433-8

    authors: Salami SO,Afolayan AJ

    更新日期:2021-01-13 00:00:00

  • Haptoglobin polymorphism and prostate cancer mortality.

    abstract::Prostate cancer is a common malignancy in men worldwide and it is known that oxidative stress is a risk factor for cancer development. A common functional haptoglobin (Hp) polymorphism, originating from a duplication of a gene segment spanning over two exons, results in three distinct phenotypes with different anti-ox...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69333-z

    authors: Kaiser M,Thurner EM,Mangge H,Herrmann M,Semeraro MD,Renner W,Langsenlehner T

    更新日期:2020-08-04 00:00:00

  • Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test.

    abstract::This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77961-8

    authors: Garcés MF,Buell-Acosta JD,Rodríguez-Navarro HA,Pulido-Sánchez E,Rincon-Ramírez JJ,Moreno-Ordóñez DC,Franco-Vega R,Roncancio-Muñoz JS,Burgos-Cardenas AJ,Lacunza E,Castaño JP,Diéguez C,Nogueiras R,Sanchez E,Caminos JE

    更新日期:2020-12-03 00:00:00