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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test.

Abstract：

:This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Garcés MF,Buell-Acosta JD,Rodríguez-Navarro HA,Pulido-Sánchez E,Rincon-Ramírez JJ,Moreno-Ordóñez DC,Franco-Vega R,Roncancio-Muñoz JS,Burgos-Cardenas AJ,Lacunza E,Castaño JP,Diéguez C,Nogueiras R,Sanchez E,Caminos JE

doi

10.1038/s41598-020-77961-8

subject

Has Abstract

pub_date

2020-12-03 00:00:00

pages

21118

issue

1

issn

2045-2322

pii

10.1038/s41598-020-77961-8

journal_volume

10

pub_type

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