Abstract:
INTRODUCTION:In regenerative endodontic treatment (RET) for immature permanent tooth, better treatment results could be obtained by applying platelet-rich plasma (PRP) as the scaffold rather than the blood clot. The goal of this study was to compare the histologic differences between using PRP and blood clot in RET. METHODS:Three 6-month-old beagles each carrying 9 premolars with double root canals were randomly assigned to the PRP group, blood clot group, or negative control group. All experimental teeth suffered apical periodontitis, and RET was performed. In the blood clot group, bleeding was induced from the periapical tissues to fill the canal space. In the PRP group, autologous PRP was injected into each root canal. The animals were sacrificed 3 months later. Histologic sections were stained with hematoxylin-eosin. Statistical analysis was performed by the Fisher exact test, with the significance set at 0.05. RESULTS:With the ingrowth of cellular cementumlike tissues, the canal wall was thickened, and the apical apex was closed in both the PRP and blood clot groups. Cementocytelike cells were present in the newly formed tissues. Meanwhile, no statistical difference was found in both experimental groups for the average percentage of apical closure, new tissue formation, and pulplike tissue formation. Noticeably, a large number of inflammatory cells were present in some root canals in both groups although the postoperative radiograph revealed the disappearance of periapical radiolucency. CONCLUSIONS:PRP application could be an option for clinical cases in which little or no bleeding were found when irritating the apical tissue during RET.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Zhang DD,Chen X,Bao ZF,Chen M,Ding ZJ,Zhong Mdoi
10.1016/j.joen.2014.03.020subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1388-93issue
9eissn
0099-2399issn
1878-3554pii
S0099-2399(14)00333-1journal_volume
40pub_type
杂志文章abstract:INTRODUCTION:The aim of this study was to assess the root canal configurations in permanent mandibular lateral incisors (PMLIs) and the correlation between the root canal configurations of PMLIs with the appearance of a distolingual root (DLR) in permanent mandibular first molars (PMFMs) using cone-beam computed tomogr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.08.027
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Studies have found women try to avoid pain more than men, accept it less, and fear it more. The role of operator gender on subject gender pain in a clinical setting needs further study. The purpose of this randomized, double-blind investigation was to evaluate operator gender and its influence on reported ...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2014.10.001
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Enterococcus faecalis is a frequently isolated microorganism in persistent periapical lesion or secondary infection. However, no evidence has demonstrated that E. faecalis induced inflammation directly in the apical area. This study aimed to explore the mechanism of the inflammatory responses of human peri...
journal_title:Journal of endodontics
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doi:10.1016/j.joen.2015.08.028
更新日期:2015-12-01 00:00:00
abstract::The aim of this review was to consider laboratory experiments and clinical studies of calcium hydroxide-based root canal sealers. An extensive search of the endodontic literature was made to identify publications related to calcium hydroxide-based root canal sealers. The articles were assessed for the outcome of labor...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2008.11.026
更新日期:2009-04-01 00:00:00
abstract::In this study, we examined the effects of TNF-alpha on Bone morphogenetic protein (BMP-2), Smads (which play intracellular signaling of BMPs) expression and alkaline phosphatase (ALP) activity of human dental pulp (HDP) cells to clarify the mechanism of tertiary dentin formation. The quantity of RT-PCR product for BMP...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2005.12.007
更新日期:2006-06-01 00:00:00
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journal_title:Journal of endodontics
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doi:10.1016/j.joen.2017.03.029
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Proteinases play pivotal roles in Candida albicans infections. Although the yeast can colonize the pulpal environment, there is no information about the enzymatic profile of this organism. This in vitro study aimed to determine the proteolysis levels and to investigate differences in the expression of aspa...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.01.012
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:The choice of single- versus multiple-visit root canal treatment for infected teeth is in dispute. The purpose of this systematic review was to compare the healing rate and post-obturation pain of single- versus multiple-visit root canal treatment for teeth with infected root canals. METHODS:An exhaustive...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2010.09.005
更新日期:2011-02-01 00:00:00
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更新日期:2017-05-01 00:00:00
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abstract::Ultrasonic instruments are a valuable asset for removing intraradicular posts from root canals before nonsurgical endodontic therapy. The purpose of this study was to evaluate the relative efficacy of post removal by ultrasonic and sonic devices. Fifty extracted teeth were instrumented and obturated. The canals were p...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80044-0
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:Securing a reproducible glide path before instrumentation is recommended to maintain the original geometry of the root canal system and to prevent file separation. Mechanical glide path management systems have been introduced to expedite this step. The aim of this study was to compare apical transportation...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.07.014
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:There are no long-term, prospective clinical studies assessing outcomes of endodontically treated cracked teeth with radicular extensions. The purpose of this prospective study was to examine the 2- to 4-year success and survival rates of endodontically treated, coronally restored, cracked teeth, specifica...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.03.015
更新日期:2019-07-01 00:00:00
abstract::The biocompatibility and apical microleakage of tricalcium phosphate based Sankin Apatite (SA) Type I, II, and III root canal sealers were investigated. Teflon tubes containing freshly mixed test materials were implanted in the subcutaneous tissue of mice. The observation periods were 24 h, 7, and 30 days, after which...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/s0099-2399(97)80255-5
更新日期:1997-02-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.01.007
更新日期:2011-05-01 00:00:00
abstract::In vitro root surface temperatures produced during post space preparation were measured. The preparations were made using a GPX bur with rotational speeds of 6,500, 8,000, 9,500, 11,000, and 15,000 rpm. The overall mean temperature increase ranged from 0.66 degree to 4.81 degrees C and was greatest at 8,000 rpm. When ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80264-0
更新日期:1996-06-01 00:00:00
abstract::The aim of this study was to assess the cytotoxicity of pure eugenol in an in vitro method by diluting it to various concentrations in alcohol and determining the maximum noncytotoxic concentration. We used solutions of eugenol and ethyl alcohol that are soluble in water in any given proportion. The cytotoxicity of th...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80012-4
更新日期:1996-10-01 00:00:00
abstract::Regulated cell death (RCD) is a preferred term inclusive of all modes of cell death regulated by multiple intracellular signal transduction pathways under physiological and pathologic conditions. Although cell death programs ensure correct growth and developmental processes as well as protect the host against microbia...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2020.07.006
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:This study evaluated the influence of glide path on canal curvature and axis modification after instrumentation with WaveOne Primary reciprocating files. METHODS:Thirty ISO 15, 0.02 taper Endo Training Blocks were used. In group 1, glide path was created with PathFile 1, 2, and 3 at working length, wherea...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.09.030
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Mineral trioxide aggregate (MTA) has been used successfully for perforation repair, vital pulpotomies, and direct pulp capping. However, little is known about the interactions between MTA and glass ionomer cement (GIC) in final restorations. In this study, 2 null hypotheses were tested: (1) GIC placement t...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.10.002
更新日期:2013-02-01 00:00:00
abstract::The purpose of this study was to compare ultrasonic and high-speed-bur root-end preparations. Seventy-six roots from 29 bilaterally matched pairs of human teeth in cadavers were used in this study. In group 1 ultrasonic preparations were made in 38 roots and filled with amalgam. In group 2 high-speed bur preparations ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/s0099-2399(97)80301-9
更新日期:1997-07-01 00:00:00
abstract:INTRODUCTION:The morphogenic complexities of dens invaginatus (DI) Oehlers type 3 in maxillary canines offer significant endodontic challenges. METHODS:A case report is provided of a 14-year-old female patient who presented with an anomalous-looking permanent maxillary canine associated with a sinus tract. Pulp testin...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.06.008
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Root fusion is an anatomic variation in maxillary second molars (MSMs); however, the nature of this canal morphology as it relates to its root anatomy has not been fully clarified. The purpose of this study was to investigate the relationship between features of fused roots and root canal anatomy in MSMs u...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.10.035
更新日期:2014-06-01 00:00:00
abstract::A descriptive, cross sectional survey was developed to determine the preferences of endodontists when prescribing analgesics. Eleven clinical scenarios describing common endodontic diagnoses or procedures with specified severity of pain were provided. A survey was sent to 310 AAE members and 63 responded, providing a ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2006.07.015
更新日期:2006-12-01 00:00:00
abstract:INTRODUCTION:This study aimed to analyze the external and internal morphologies of 3-rooted maxillary first premolars using cone-beam computed tomographic (CBCT) imaging. METHODS:Fifty-six three-rooted maxillary first premolars were imaged by CBCT imaging and classified into 4 groups on the basis of external root morp...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.03.045
更新日期:2017-08-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2018.07.018
更新日期:2018-11-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2009.11.010
更新日期:2010-03-01 00:00:00
abstract::The effects of various cleaning, chemical disinfection, and sterilization procedures on the cutting efficiency of endodontic instruments Unifile (De Trey, Bois Colombes, France), (Flexofile Maillefer, Ballaigues, Switzerland), and H-File (Maillefer)) were investigated. The cross-infection control treatment procedures ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80059-8
更新日期:1996-12-01 00:00:00
abstract::Historically, pulp-necrotizing agents were commonly used in endodontic treatments. They act quickly and devitalize the pulp within a few days. However, they are cytotoxic to gingiva and bone. If such an agent diffuses out of the cavity, it can readily cause widespread necrosis of gingiva and bone, which can lead to os...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000125881.18872.ef
更新日期:2004-10-01 00:00:00