Abstract：
:Historically, pulp-necrotizing agents were commonly used in endodontic treatments. They act quickly and devitalize the pulp within a few days. However, they are cytotoxic to gingiva and bone. If such an agent diffuses out of the cavity, it can readily cause widespread necrosis of gingiva and bone, which can lead to osteomyelitis of the jaws. Although the use of arsenic trioxide can cause severe damage to surrounding tissues, producing complications, it is still used in certain areas in the world. This article presents and discusses two cases of tissue necrosis and their surgical management. These cases showed severe alveolar bone loss in the maxilla, which affected the patients' quality of life and limited the restorative possibilities. As dentists, we should be aware of the hazardous effects of arsenic trioxide and should abandon its use. Because of its cytotoxicity, there is no justification for the use of arsenic trioxide in the modern dental practice.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Garip H,Salih IM,Sener BC,Göker K,Garip Ydoi
10.1097/01.don.0000125881.18872.efkeywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
732-6issue
10eissn
0099-2399issn
1878-3554pii
00004770-200410000-00013journal_volume
30pub_type
杂志文章abstract：:In this study, the effects of heparin on dentinal resorption was investigated in rats. Animals were injected with 2 x 2 IU/g Na-Heparin subcutaneously for 33 days. Histopathological examination of the anterior teeth revealed capillary proliferation, congestion, and fibrosis in the pulp in addition to resorptive lacuna...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(99)80347-1
更新日期：1999-10-01 00:00:00
abstract：:The purpose of this study was to evaluate the bleaching effect of sodium percarbonate on artificially stained pulpless teeth. Twenty extracted human mandibular premolars were stained by immersing them in human blood mixed with iron sulfide, and divided into three test groups and one control group. The following bleach...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200001000-00006
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:Various factors may influence intracanal calcification in teeth treated with regenerative endodontic procedures. Bioactive materials, including ProRoot MTA (MTA; Dentsply Tulsa Dental Specialties, Memphis, TN) and Biodentine (BD; Septodont, Saint-Maur-des-Fossés, France), have been widely used as a coronal...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2019.03.011
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:The purposes of this retrospective study were to evaluate the clinical and radiographic outcomes of mineral trioxide aggregate apexification and revascularization in nonvital immature permanent teeth and to analyze factors influencing treatment outcome. METHODS:Forty-six cases (29 cases of apexification a...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.10.030
更新日期：2017-02-01 00:00:00
abstract：INTRODUCTION:The ability to resolve pulpal inflammation to achieve predictable regeneration of the dentin-pulp complex has remained elusive and presents a challenge for clinicians and researchers. Although the dentin-pulp complex can react naturally to injury by forming a bridge of reparative dentin that protects the p...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2020.06.039
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:Stem cells from the apical papilla (SCAPs) possess strong odonto/osteogenic differentiation potential. This study investigated the effect of cyclic adenosine monophosphate (cAMP) on odonto/osteogenic differentiation of SCAPs and the underlining interplay between cAMP and transforming growth factor beta 1 (...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.10.008
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Concentrated growth factor (CGF) is considered to be a natural biomaterial that is better than platelet-rich fibrin (PRF) in bone regeneration, but there is little information acquired in regenerative endodontics. Therefore, the purpose of this study was to evaluate their effects on the proliferation, migr...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.03.006
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:This article reports on the feasibility of conducting a large-scale endodontic prospective cohort study in The National Dental Practice-Based Research Network. This study was designed to measure pain and burden associated with initial orthograde root canal therapy (RCT) and to explore potential prognostic ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.08.002
更新日期：2012-11-01 00:00:00
abstract：:The mesiobuccal roots of 50 randomly selected maxillary first molars were examined to assess the incidence and position of the canal isthmus. Transverse serial sections of the apical 6 mm of each root were prepared in 1-mm increments. The apical side of each section was stained with methylene blue dye, viewed with a s...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/s0099-2399(06)80975-1
更新日期：1995-07-01 00:00:00
abstract：:Pulp regeneration and its clinical translation into regenerative endodontic procedures are receiving increasing research attention, leading to significant growth of the published scientific and clinical literature within these areas. Development of research strategies, which consider patient-, clinician-, and scientis...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.06.002
更新日期：2017-09-01 00:00:00
abstract：:The objective of this study was to evaluate the cytotoxicity of three endodontic sealers (AH Plus/Maillefer-Dentsply, Epiphany/Pentron, GuttaFlow, Coltene-Whaledent). Materials were mixed according to the manufacturer instructions and packed into Teflon molds (10 x 1 mm). For cytotoxicity testing (MTT method), the spe...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2006.05.006
更新日期：2006-10-01 00:00:00
abstract：:Regulated cell death (RCD) is a preferred term inclusive of all modes of cell death regulated by multiple intracellular signal transduction pathways under physiological and pathologic conditions. Although cell death programs ensure correct growth and developmental processes as well as protect the host against microbia...
journal_title：Journal of endodontics
pub_type： 杂志文章,评审
doi：10.1016/j.joen.2020.07.006
更新日期：2020-10-01 00:00:00
abstract：:Sodium hypochlorite (NaOCl) has been recommended for irrigation during root canal preparation. This investigation used scanning electron microscopy to examine instrumented and uninstrumented surfaces in the middle third of root canals following the use of several concentrations of NaOCl (5.25%, 2.5%, 1.0%, and 0.5%). ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(06)81331-2
更新日期：1992-12-01 00:00:00
abstract：INTRODUCTION:Surgical interventions such as tooth extraction increase the chances of developing osteonecrosis of the jaw in patients receiving bisphosphonates (BPs) for the treatment of bone-related diseases. Tooth extraction is often performed to eliminate preexisting pathological inflammatory conditions that make the...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.07.020
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:This clinical study evaluates the effect of ultrasonic root-end preparations on dentinal defect creation and propagation. METHODS:Eighty-four teeth were treated with periapical microsurgery using a modern microsurgical protocol in a private practice setting. The root apices were resected and inspected for...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.07.016
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:This study compared the accuracy of cone beam computed tomography (CBCT) scans made by five different systems in detecting vertical root fractures (VRFs). It also assessed the influence of the presence of root canal filling (RCF), CBCT slice orientation selection, and the type of tooth (premolar/molar) on ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2009.09.013
更新日期：2010-01-01 00:00:00
abstract：:Cytotoxicity was compared between new root canal sealers (New A, New B, and New B-2) and conventional root canal sealers (AH26, Diaket, Canals, Tubi-Seal, and Sealapex). Dental pulp cells of rats, obtained through primary cell culture, were used. In the experiments with the freshly prepared sealers, the incorporation ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(89)80109-8
更新日期：1989-02-01 00:00:00
abstract：INTRODUCTION:The effect of rheumatoid arthritis (RA) on the healing and pathophyisiology of apical periodontitis is unknown because there is no study in the literature evaluating the association of RA with the prevalence of periapical rarefying osteitis (PAR) and endodontic treatment. Therefore, the goal of this cross-...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.02.015
更新日期：2017-07-01 00:00:00
abstract：:The aim of this laboratory based study was to determine the shaping ability of Lightspeed nickel-titanium rotary instruments in simulated root canals. A total of 40 canals with four different shapes in terms of angle and position of curve were prepared with Lightspeed instruments using the stepback technique recommend...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(97)80347-0
更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to examine the effect of mineral trioxide aggregate (MTA) on pluripotent-mesenchymal cell differentiation. METHODS:The pluripotent-mesenchymal cell line C2C12 was cultured in a 5% serum medium to induce cell differentiation with or without MTA. The differentiation to myoblast...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.10.006
更新日期：2013-01-01 00:00:00
abstract：:The purpose of this study was to determine the influence of operator experience on the ability to locate and fill extra canals in maxillary first and second molars in vivo. The number of canals located and filled from maxillary first and second molars was recorded from three endodontic residents during the first 6 mon...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2005.11.005
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:External apical root resorption (EARR) is a frequent iatrogenic effect of orthodontic treatment. The way root-filled teeth respond to orthodontic forces with respect to EARR has been reported as varying widely between individuals. Genetic variants in the interleukin-1 gene have been associated with an incr...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2011.12.022
更新日期：2012-03-01 00:00:00
abstract：:This study compared the apical seal produced by four obturation techniques. Sixty-four extracted human teeth were prepared and obturated using lateral condensation of gutta-percha that was either unmodified or was dipped in chloroform, eucalyptol, or eucapercha paste. After storage in normal saline and 0.02% azide sol...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(89)80158-X
更新日期：1989-12-01 00:00:00
abstract：INTRODUCTION:Interferon regulatory factor 8 (IRF8) is a critical transcription factor in innate immune responses that regulates the development and function of myeloid cells. Human periapical lesions are caused by endodontic microbial infections. However, the presence of IRF8 in human periapical lesions remains elusive...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.04.015
更新日期：2018-08-01 00:00:00
abstract：:The aim of this review was to consider laboratory experiments and clinical studies of calcium hydroxide-based root canal sealers. An extensive search of the endodontic literature was made to identify publications related to calcium hydroxide-based root canal sealers. The articles were assessed for the outcome of labor...
journal_title：Journal of endodontics
pub_type： 杂志文章,评审
doi：10.1016/j.joen.2008.11.026
更新日期：2009-04-01 00:00:00
abstract：INTRODUCTION:Endodontic diagnostic tests are often used clinically to assess pulp status as a basis for the diagnosis and determination of whether root canal treatment (RCT) is indicated. Response to cold and pain on percussion are 2 common tests, yet their validity in identifying nonvital pulp in regular dental practi...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.03.016
更新日期：2016-06-01 00:00:00
abstract：:The purpose of this study was to develop a method for lidocaine detection in dental pulp by high-performance liquid chromatography. The amounts of lidocaine in dog pulps were quantitated after local injection to evaluate lidocaine recovery from pulp tissue with this technique. Comparison was also made between the amou...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200101000-00009
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to compare canal transportation and the centering ability of Reciproc (VDW, Munich, Germany), WaveOne (Dentsply Maillefer, Ballaigues, Switzerland), and EdgeFile (EdgeEndo, Albuquerque, NM) rotary systems using cone-beam computed tomographic imaging. METHODS:Ninety mesiobucca...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.09.011
更新日期：2018-12-01 00:00:00
abstract：:The aim of this in vivo study was to find a way to conduct qualitative and quantitative evaluations of radicular apical third apposition in rats. Twenty rats were injected intraperitoneally with tetracycline at weight-adjusted doses. Mesio-distal sections of the first mandibular molar regions were prepared. The 60 to ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(99)80153-8
更新日期：1999-04-01 00:00:00
abstract：:Patients with odontogenic cutaneous sinus tracts usually seek treatment from a physician instead of a dentist and the etiology is frequently misdiagnosed. This case report describes a patient who sought treatment from a dentist because of a history of a previous cutaneous swelling on the ipsilateral side of his cheek....
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/s0099-2399(06)80959-3
更新日期：1992-06-01 00:00:00
