Initiation of sporulation in Clostridium difficile: a twist on the classic model.

Abstract:

:The formation of dormant endospores is a complex morphological process that permits long-term survival in inhospitable environments for many Gram-positive bacteria. Sporulation for the anaerobic gastrointestinal pathogen Clostridium difficile is necessary for survival outside of the gastrointestinal tract of its host. While the developmental stages of spore formation are largely conserved among endospore-forming bacteria, the genus Clostridium appears to be missing a number of conserved regulators required for efficient sporulation in other spore-forming bacteria. Several recent studies have discovered novel mechanisms and distinct regulatory pathways that control the initiation of sporulation and early-sporulation-specific gene expression. These differences in regulating the decision to undergo sporulation reflects the unique ecological niche and environmental conditions that C. difficile inhabits and encounters within the mammalian host.

journal_name

FEMS Microbiol Lett

authors

Edwards AN,McBride SM

doi

10.1111/1574-6968.12499

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

110-8

issue

2

eissn

0378-1097

issn

1574-6968

journal_volume

358

pub_type

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