Abstract:
:The formation of dormant endospores is a complex morphological process that permits long-term survival in inhospitable environments for many Gram-positive bacteria. Sporulation for the anaerobic gastrointestinal pathogen Clostridium difficile is necessary for survival outside of the gastrointestinal tract of its host. While the developmental stages of spore formation are largely conserved among endospore-forming bacteria, the genus Clostridium appears to be missing a number of conserved regulators required for efficient sporulation in other spore-forming bacteria. Several recent studies have discovered novel mechanisms and distinct regulatory pathways that control the initiation of sporulation and early-sporulation-specific gene expression. These differences in regulating the decision to undergo sporulation reflects the unique ecological niche and environmental conditions that C. difficile inhabits and encounters within the mammalian host.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Edwards AN,McBride SMdoi
10.1111/1574-6968.12499subject
Has Abstractpub_date
2014-09-01 00:00:00pages
110-8issue
2eissn
0378-1097issn
1574-6968journal_volume
358pub_type
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