Metabolism of sialic acid by Bifidobacterium breve UCC2003.

Abstract:

:Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010.

journal_name

Appl Environ Microbiol

authors

Egan M,O'Connell Motherway M,Ventura M,van Sinderen D

doi

10.1128/AEM.01114-14

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

4414-26

issue

14

eissn

0099-2240

issn

1098-5336

pii

AEM.01114-14

journal_volume

80

pub_type

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