Abstract:
:Significance: Revealing the basic mechanisms in the healing process and then regulating these processes for faster healing or to avoid negative outcomes such as infection or scarring are fundamental to wound research. The normal healing process is basically known, but to thoroughly understand the very complex aspects involved, it is necessary to characterize the course of events at a higher resolution with the latest molecular techniques and methodologies. Recent Advances: Various animal models are used in wound-healing research. Rodent and pig models are the ones most often used, probably because of pre-existing sophisticated research methodologies and as the proper care and ethical use of these species are highly developed and organized to serve science throughout the world. Critical Issues: Since several animal models are used, their anatomical and physiological differences varyingly affect the translation of results on healing mechanisms. Hence, to avoid species-specific misinformation, more ways to study wound healing directly in humans are needed. Future Directions: Fortunately, novel techniques have enabled high-end molecular-level research even from small samples of tissue. Since these methods require only a small amount of patient skin, they make it possible to study wound healing directly in humans.
journal_name
Adv Wound Care (New Rochelle)journal_title
Advances in wound careauthors
Nuutila K,Katayama S,Vuola J,Kankuri Edoi
10.1089/wound.2013.0502subject
Has Abstractpub_date
2014-03-01 00:00:00pages
264-271issue
3eissn
2162-1918issn
2162-1934pii
10.1089/wound.2013.0502journal_volume
3pub_type
评审abstract::Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0931
更新日期:2019-08-01 00:00:00
abstract::Significance: Regulation of cell adhesions during tissue repair is fundamentally important for cell migration, proliferation, and protein production. All cells interact with extracellular matrix proteins with cell surface integrin receptors that convey signals from the environment into the nucleus, regulating gene exp...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2013.0436
更新日期:2014-12-01 00:00:00
abstract::Objective: To develop a venous leg ulcer (VLU) risk stratification system for use in research and clinical practice. Approach: U.S. Wound Registry data were examined retrospectively and assigned an outcome. Bivariate analysis identified significant variables (p < 0.05) that were used to create a multivariable logistic...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.1038
更新日期:2020-02-01 00:00:00
abstract::Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2013.0489
更新日期:2014-03-01 00:00:00
abstract:PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2011.0290
更新日期:2012-02-01 00:00:00
abstract:SIGNIFICANCE:Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a basic science and pre-clinical perspective, seems ideal for the therapeutic stimulation of blood ves...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2011.0348
更新日期:2013-04-01 00:00:00
abstract::Significance: Keloids are benign fibro-proliferative raised dermal lesions that spread beyond the original borders of the wound, continue to grow, rarely regress, and are the most common in pigmented individuals after an abnormal wound healing response. The current treatment failure and respective challenges involved ...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2019.1040
更新日期:2019-12-01 00:00:00
abstract::Objective: Full-thickness burn wounds require immediate coverage, and the primary clinical approaches comprise of skin allografts and autografts. The use of allografts is often temporary due to the antigenicity of allografts. In contrast, the availability of skin autografts may be limited in large burn injuries. In su...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.1108
更新日期:2020-05-28 00:00:00
abstract::Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the rec...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0827
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Adipose tissue is one of the richest sources of mesenchymal stem cells that exhibit an outstanding ability to regenerate skin. THE PROBLEM:Although the anatomical sites of adipose-derived stem cells (ASCs) in the body are relatively oxygen-deficient (i.e., 1%-5% oxygen content), ASCs are usually cultured un...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2011.0312
更新日期:2012-08-01 00:00:00
abstract::Significance: Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity. Compared to this benchmark, all postnatal wound healing is impaired and characterized by scar formation. The biologic basis of the fetal regenerative phenotype can serve as a road...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2014.0564
更新日期:2015-11-01 00:00:00
abstract::Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach ...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2017.0752
更新日期:2018-05-01 00:00:00
abstract::Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb l...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2016.0714
更新日期:2017-08-01 00:00:00
abstract:SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2012.0398
更新日期:2013-07-01 00:00:00
abstract::The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2015.0653
更新日期:2016-10-01 00:00:00
abstract:SIGNIFICANCE:Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have a significant impact on the quality of life of the patient, particularly where function and appeara...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2012.0378
更新日期:2013-05-01 00:00:00
abstract::Objective: Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Approach: Double transgenic mice were created by crossbreeding ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2017.0772
更新日期:2018-01-01 00:00:00
abstract::Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance ...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2014.0587
更新日期:2015-07-01 00:00:00
abstract::Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.0970
更新日期:2019-11-01 00:00:00
abstract:SIGNIFICANCE:Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound healing has included the use of EGF. In addition, EGFR inhibitors (EGFRis) have become a therapeutic opti...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2011.0326
更新日期:2013-02-01 00:00:00
abstract::Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2015.0672
更新日期:2016-07-01 00:00:00
abstract::Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressi...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2015.0660
更新日期:2016-01-01 00:00:00
abstract::Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0844
更新日期:2019-07-01 00:00:00
abstract::Significance: Venous leg ulcers (VLUs) are susceptible to microbial invasion, and serious complications can result without the timely control of infection. Diagnosis of wound infection is primarily based on subjective clinical characteristics and patient-reported symptoms, and the treatment with antimicrobials has not...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2014.0535
更新日期:2015-01-01 00:00:00
abstract::Significance: Mast cells are resident inflammatory cells present in high numbers in the skin. They are one of the first cell types to respond to damage and they do so by quickly releasing a variety of preformed mediators that are stored within mast cell granules. Mast cells are not only active early on, where they hel...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2013.0457
更新日期:2014-04-01 00:00:00
abstract::Objective: To investigate the safety, feasibility, and acceptability of a novel treatment, intermittent electrical stimulation (IES), for preventing deep tissue injury (DTI) in different healthcare settings. Approach: Testing was conducted in an acute rehabilitation unit of a general hospital, a tertiary rehabilitatio...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2014.0569
更新日期:2015-03-01 00:00:00
abstract::Objective: To merge scholarly activity into the curriculum developed for medical students electing a rotation in wound care and/or dermatology. Approach: The authors adapted the unique wound care curriculum developed for medical student rotators and residents to incorporate structured scholarly projects, opportunities...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2013.0504
更新日期:2014-05-01 00:00:00
abstract::Significance: Angiogenesis is an important phenomenon involved in the healing of chronic wounds, and it is mainly mediated by the release of vascular endothelial growth factor (VEGF) from endothelial cells. Electrical stimulation (ES) is a well-documented treatment used to assist the healing of chronic wounds. Due to ...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2013.0427
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Many wounds are difficult to heal because of the large, complex community of microbes present within the wound. THE PROBLEM:Classical laboratory culture methods do not provide an accurate picture of the microbial interactions or representation of microorganisms within a wound. There is an inherent bias in d...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2011.0303
更新日期:2012-06-01 00:00:00
abstract::Introduction: Chronic wounds that are difficult to heal are physical and financial burden to the sufferer and a challenge to the treating physician. Objective: The main purpose of this study was to develop a novel method of using bone marrow (BM) aspirate, either cultured or fresh, as early solution for healing of chr...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2016.0704
更新日期:2017-04-01 00:00:00