The Management of Combat Wounds: The British Military Experience.

abstract：:Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb l...

journal_title：Advances in wound care

authors： Butowicz CM,Dearth CL,Hendershot BD

更新日期：2017-08-01 00:00:00

abstract：:Rationale: The Tight Skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of human disease, including tight skin, excessive collagen deposition, alterations in the extracellular matrix (ECM), increased elastic fibers, and occurrence of antinuclear antibodies with age. A tight skin phenotype is obser...

journal_title：Advances in wound care

authors： Long KB,Burgwin CM,Huneke R,Artlett CM,Blankenhorn EP

更新日期：2014-09-01 00:00:00

abstract：:Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...

journal_title：Advances in wound care

authors： Foubert P,Gonzalez AD,Teodosescu S,Berard F,Doyle-Eisele M,Yekkala K,Tenenhaus M,Fraser JK

更新日期：2016-07-01 00:00:00

abstract：SIGNIFICANCE:Proteases and their inhibitors contribute to the balance between extracellular matrix (ECM) degradation and deposition, creating an equilibrium that is essential for the timely and coordinated healing of cutaneous wounds. However, when this balance is disrupted, wounds are led into a state of chronicity ch...

journal_title：Advances in wound care

authors： McCarty SM,Percival SL

更新日期：2013-10-01 00:00:00

abstract：:Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance ...

journal_title：Advances in wound care

authors： Ganesh K,Sinha M,Mathew-Steiner SS,Das A,Roy S,Sen CK

更新日期：2015-07-01 00:00:00

abstract：:Objective: To investigate the safety, feasibility, and acceptability of a novel treatment, intermittent electrical stimulation (IES), for preventing deep tissue injury (DTI) in different healthcare settings. Approach: Testing was conducted in an acute rehabilitation unit of a general hospital, a tertiary rehabilitatio...

journal_title：Advances in wound care

authors： Ahmetović A,Mushahwar VK,Sommer R,Schnepf D,Kawasaki L,Warwaruk-Rogers R,Barlott T,Chong SL,Isaacson G,Kim S,Ferguson-Pell M,Stein RB,Ho C,Dukelow S,Chan KM

更新日期：2015-03-01 00:00:00

abstract：:Objective: To determine the utility of instillation negative pressure wound therapy (NPWT) in achieving eradication of infection and definitive wound closure in patients with infected left ventricular assist device (LVAD). Approach: A retrospective review was performed in a series of patients with infected and exposed...

journal_title：Advances in wound care

authors： Hodson T,West JM,Poteet SJ,Lee PH,Valerio IL

更新日期：2019-03-01 00:00:00

abstract：:Chronic and hard-to-heal wounds are a tremendous burden on our healthcare system and impair the quality of life for millions of people. An emerging focus of regenerative medicine is the development of natural biomaterials that can stimulate tissue formation or repair by recreating the functional and structural propert...

journal_title：Advances in wound care

authors： Hocking DC

更新日期：2015-08-01 00:00:00

abstract：:Objective: Exposure to ultraviolet (UV) light from the sun is known to accelerate the skin aging process and leads to significant alterations in skin biomechanics; however, the molecular mechanisms by which chronic UVB affects biomechanical properties of the skin have not been well described. Approach: A murine model ...

journal_title：Advances in wound care

authors： Blackstone BN,Wilgus TA,Roy S,Wulff BC,Powell HM

更新日期：2020-03-01 00:00:00

abstract：:Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, wh...

journal_title：Advances in wound care

authors： D'Arpa P,Leung KP

更新日期：2017-10-01 00:00:00

abstract：SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...

journal_title：Advances in wound care

authors： Balaji S,King A,Crombleholme TM,Keswani SG

更新日期：2013-07-01 00:00:00

abstract：:Introduction: Chronic wounds that are difficult to heal are physical and financial burden to the sufferer and a challenge to the treating physician. Objective: The main purpose of this study was to develop a novel method of using bone marrow (BM) aspirate, either cultured or fresh, as early solution for healing of chr...

journal_title：Advances in wound care

authors： Gupta GJ,Karki K,Jain P,Saxena AK

更新日期：2017-04-01 00:00:00

abstract：:Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the rec...

journal_title：Advances in wound care

authors： O'Rourke BP,Kramer AH,Cao LL,Inayathullah M,Guzik H,Rajadas J,Nosanchuk JD,Sharp DJ

更新日期：2019-03-01 00:00:00

abstract：:Objective: To inform on the interim results of the Remede d'Or study, which is a prospective, multicenter, single-blind, randomized, controlled clinical study on the safety and efficacy of RMD-G1, a topical carbopol-based hydrogel with a fibronectin matrix whose active pharmaceutical ingredient is erythropoietin (EPO)...

journal_title：Advances in wound care

authors： Hamed S,Belokopytov M,Ullmann Y,Safadi M,Stark Y,Shoufani A,Akita S,Liu PY,Teot L

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has changed from studying individual genes and proteins to analyzing entire genomes and proteomes. APPRO...

journal_title：Advances in wound care

authors： Bunnik EM,Le Roch KG

更新日期：2013-11-01 00:00:00

abstract：:Significance: Keloids are benign fibro-proliferative raised dermal lesions that spread beyond the original borders of the wound, continue to grow, rarely regress, and are the most common in pigmented individuals after an abnormal wound healing response. The current treatment failure and respective challenges involved ...

journal_title：Advances in wound care

authors： Sharma JR,Lebeko M,Kidzeru EB,Khumalo NP,Bayat A

更新日期：2019-12-01 00:00:00

abstract：:Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...

journal_title：Advances in wound care

authors： Natesan S,Stone R,Coronado RE,Wrice NL,Kowalczewski AC,Zamora DO,Christy RJ

更新日期：2019-07-01 00:00:00

abstract：:Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review...

journal_title：Advances in wound care

authors： Ho J,Walsh C,Yue D,Dardik A,Cheema U

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Many wounds are difficult to heal because of the large, complex community of microbes present within the wound. THE PROBLEM:Classical laboratory culture methods do not provide an accurate picture of the microbial interactions or representation of microorganisms within a wound. There is an inherent bias in d...

journal_title：Advances in wound care

authors： Tatum OL,Dowd SE

更新日期：2012-06-01 00:00:00

abstract：:Objective: To develop a venous leg ulcer (VLU) risk stratification system for use in research and clinical practice. Approach: U.S. Wound Registry data were examined retrospectively and assigned an outcome. Bivariate analysis identified significant variables (p < 0.05) that were used to create a multivariable logistic...

journal_title：Advances in wound care

authors： Fife CE,Horn SD

更新日期：2020-02-01 00:00:00

abstract：:Significance: Bacterial burden is believed to play a significant role in impaired wound healing of chronic wounds and the development of infection-related complications. The standard of care in the clinic relies upon cultivation-dependent methods to identify microorganisms. These assays are biased toward microorganism...

journal_title：Advances in wound care

authors： Misic AM,Gardner SE,Grice EA

更新日期：2014-07-01 00:00:00

abstract：:Significance: Pressure ulcers (PUs) in newborns and children are remarkably different from those in adults, both in their possible causal factors and in the etiology and biomechanical pathways for tissue damage. Recent Advances: Pediatric muscle and fat tissue structures are overall softer than those of adults, making...

journal_title：Advances in wound care

authors： Levy A,Kopplin K,Gefen A

更新日期：2015-10-01 00:00:00

abstract：:Significance: Chronic skin ulcers, including venous, diabetic, and pressure ulcers, constitute a major health care burden, affecting 2-6 million people in the United States alone, with projected increases in incidence owing to the aging population and rising epidemic of diabetes. The ulcers are often accompanied by pa...

journal_title：Advances in wound care

authors： Siadat AH,Isseroff RR

更新日期：2019-04-01 00:00:00

abstract：:Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...

journal_title：Advances in wound care

authors： Dhall S,Hoffman T,Sathyamoorthy M,Lerch A,Jacob V,Moorman M,Kuang JQ,Danilkovitch A

更新日期：2019-08-01 00:00:00

abstract：:Significance: Angiogenesis is an important phenomenon involved in the healing of chronic wounds, and it is mainly mediated by the release of vascular endothelial growth factor (VEGF) from endothelial cells. Electrical stimulation (ES) is a well-documented treatment used to assist the healing of chronic wounds. Due to ...

journal_title：Advances in wound care

authors： Liebano RE,Machado AF

更新日期：2014-02-01 00:00:00

abstract：:Objective: The contemporary treatment of a full-thickness burn consists of early eschar excision followed by immediate closure of the open wound using autologous skin. However, most animal models study burn wound healing with the persistence of the burn eschar. Our goal is to characterize a murine model of burn eschar...

journal_title：Advances in wound care

authors： Wu JC,Rose LF,Christy RJ,Leung KP,Chan RK

更新日期：2015-02-01 00:00:00

abstract：:Significance: Revealing the basic mechanisms in the healing process and then regulating these processes for faster healing or to avoid negative outcomes such as infection or scarring are fundamental to wound research. The normal healing process is basically known, but to thoroughly understand the very complex aspects ...

journal_title：Advances in wound care

authors： Nuutila K,Katayama S,Vuola J,Kankuri E

更新日期：2014-03-01 00:00:00

abstract：:Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...

journal_title：Advances in wound care

authors： Hopkinson SB,Hamill KJ,Wu Y,Eisenberg JL,Hiroyasu S,Jones JC

更新日期：2014-03-01 00:00:00

abstract：SIGNIFICANCE:Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have a significant impact on the quality of life of the patient, particularly where function and appeara...

journal_title：Advances in wound care

authors： Sharpe JR,Martin Y

更新日期：2013-05-01 00:00:00

abstract：SIGNIFICANCE:Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound healing has included the use of EGF. In addition, EGFR inhibitors (EGFRis) have become a therapeutic opti...

journal_title：Advances in wound care

authors： Bodnar RJ

更新日期：2013-02-01 00:00:00