Integrins in Wound Healing.

abstract：:Objective: Epidermal CD34+ stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34+ cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healin...

journal_title：Advances in wound care

authors： Li S,Hu M,Lorenz HP

更新日期：2020-05-01 00:00:00

abstract：:Objective: The contemporary treatment of a full-thickness burn consists of early eschar excision followed by immediate closure of the open wound using autologous skin. However, most animal models study burn wound healing with the persistence of the burn eschar. Our goal is to characterize a murine model of burn eschar...

journal_title：Advances in wound care

authors： Wu JC,Rose LF,Christy RJ,Leung KP,Chan RK

更新日期：2015-02-01 00:00:00

abstract：PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...

journal_title：Advances in wound care

authors： O'Connell SM,Hessler K,Dardik H

更新日期：2012-02-01 00:00:00

abstract：:Objective: To inform on the interim results of the Remede d'Or study, which is a prospective, multicenter, single-blind, randomized, controlled clinical study on the safety and efficacy of RMD-G1, a topical carbopol-based hydrogel with a fibronectin matrix whose active pharmaceutical ingredient is erythropoietin (EPO)...

journal_title：Advances in wound care

authors： Hamed S,Belokopytov M,Ullmann Y,Safadi M,Stark Y,Shoufani A,Akita S,Liu PY,Teot L

更新日期：2019-10-01 00:00:00

abstract：:Significance: Revealing the basic mechanisms in the healing process and then regulating these processes for faster healing or to avoid negative outcomes such as infection or scarring are fundamental to wound research. The normal healing process is basically known, but to thoroughly understand the very complex aspects ...

journal_title：Advances in wound care

authors： Nuutila K,Katayama S,Vuola J,Kankuri E

更新日期：2014-03-01 00:00:00

abstract：:Significance: Venous leg ulcers (VLUs) are susceptible to microbial invasion, and serious complications can result without the timely control of infection. Diagnosis of wound infection is primarily based on subjective clinical characteristics and patient-reported symptoms, and the treatment with antimicrobials has not...

journal_title：Advances in wound care

authors： Tuttle MS

更新日期：2015-01-01 00:00:00

abstract：:Objective: Activation of epidermal stem cells (EpSCs) from their quiescent niche is an integral component of wound reepithelialization and involves Wnt/β-catenin (β-Cat) signaling and remodeling of the actin cytoskeleton. The aim of this study was to investigate the effect of Flightless I (Flii), a cytoskeletal protei...

journal_title：Advances in wound care

authors： Yang GN,Strudwick XL,Bonder C,Kopecki Z,Cowin AJ

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Oxygen is vital for healing wounds. It is intricately involved in numerous biological processes including cell proliferation, angiogenesis, and protein synthesis, which are required for restoration of tissue function and integrity. Adequate wound tissue oxygenation can trigger healing responses and favorably...

journal_title：Advances in wound care

authors： Castilla DM,Liu ZJ,Velazquez OC

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Many wounds are difficult to heal because of the large, complex community of microbes present within the wound. THE PROBLEM:Classical laboratory culture methods do not provide an accurate picture of the microbial interactions or representation of microorganisms within a wound. There is an inherent bias in d...

journal_title：Advances in wound care

authors： Tatum OL,Dowd SE

更新日期：2012-06-01 00:00:00

abstract：:Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...

journal_title：Advances in wound care

authors： Foubert P,Gonzalez AD,Teodosescu S,Berard F,Doyle-Eisele M,Yekkala K,Tenenhaus M,Fraser JK

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has changed from studying individual genes and proteins to analyzing entire genomes and proteomes. APPRO...

journal_title：Advances in wound care

authors： Bunnik EM,Le Roch KG

更新日期：2013-11-01 00:00:00

abstract：:Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach ...

journal_title：Advances in wound care

authors： van Kogelenberg S,Yue Z,Dinoro JN,Baker CS,Wallace GG

更新日期：2018-05-01 00:00:00

abstract：:It was once common practice in the treatment of breast cancer for total mastectomy and axillary lymph node dissection to be conventionally performed. However, breast-conserving surgery is increasingly being performed with marked improvement in a multidisciplinary treatment approach, including surgery, chemotherapy, ir...

journal_title：Advances in wound care

authors： Yoshimoto H,Hamuy R

更新日期：2014-01-01 00:00:00

abstract：:Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...

journal_title：Advances in wound care

authors： Hopkinson SB,Hamill KJ,Wu Y,Eisenberg JL,Hiroyasu S,Jones JC

更新日期：2014-03-01 00:00:00

abstract：SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...

journal_title：Advances in wound care

authors： Balaji S,King A,Crombleholme TM,Keswani SG

更新日期：2013-07-01 00:00:00

abstract：:Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review...

journal_title：Advances in wound care

authors： Ho J,Walsh C,Yue D,Dardik A,Cheema U

更新日期：2017-06-01 00:00:00

abstract：:Significance: Bacterial burden is believed to play a significant role in impaired wound healing of chronic wounds and the development of infection-related complications. The standard of care in the clinic relies upon cultivation-dependent methods to identify microorganisms. These assays are biased toward microorganism...

journal_title：Advances in wound care

authors： Misic AM,Gardner SE,Grice EA

更新日期：2014-07-01 00:00:00

abstract：:The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...

journal_title：Advances in wound care

authors： Jeffery SL

更新日期：2016-10-01 00:00:00

abstract：:Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...

journal_title：Advances in wound care

authors： Natesan S,Stone R,Coronado RE,Wrice NL,Kowalczewski AC,Zamora DO,Christy RJ

更新日期：2019-07-01 00:00:00

abstract：:Rationale: The Tight Skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of human disease, including tight skin, excessive collagen deposition, alterations in the extracellular matrix (ECM), increased elastic fibers, and occurrence of antinuclear antibodies with age. A tight skin phenotype is obser...

journal_title：Advances in wound care

authors： Long KB,Burgwin CM,Huneke R,Artlett CM,Blankenhorn EP

更新日期：2014-09-01 00:00:00

abstract：:Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, wh...

journal_title：Advances in wound care

authors： D'Arpa P,Leung KP

更新日期：2017-10-01 00:00:00

abstract：SIGNIFICANCE:Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have a significant impact on the quality of life of the patient, particularly where function and appeara...

journal_title：Advances in wound care

authors： Sharpe JR,Martin Y

更新日期：2013-05-01 00:00:00

abstract：:Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...

journal_title：Advances in wound care

authors： Weigelt MA,McNamara SA,Sanchez D,Hirt PA,Kirsner RS

更新日期：2021-01-01 00:00:00

abstract：:Objective: To develop a venous leg ulcer (VLU) risk stratification system for use in research and clinical practice. Approach: U.S. Wound Registry data were examined retrospectively and assigned an outcome. Bivariate analysis identified significant variables (p < 0.05) that were used to create a multivariable logistic...

journal_title：Advances in wound care

authors： Fife CE,Horn SD

更新日期：2020-02-01 00:00:00

abstract：:Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...

journal_title：Advances in wound care

authors： Dhall S,Hoffman T,Sathyamoorthy M,Lerch A,Jacob V,Moorman M,Kuang JQ,Danilkovitch A

更新日期：2019-08-01 00:00:00

abstract：:Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb l...

journal_title：Advances in wound care

authors： Butowicz CM,Dearth CL,Hendershot BD

更新日期：2017-08-01 00:00:00

abstract：: Objective: In recent years, reticulated open-cell foam-based closed-incision negative pressure therapy (ROCF-ciNPT) has shown effectiveness in management of various postoperative incisions. These dressings consist of a skin interface layer that absorbs fluid from the skin ...

journal_title：Advances in wound care

authors： Kharkar PM,Osborne SN,Stern SL,Pleitner A,Wiencek KM,Kieswetter KM

更新日期：2020-08-01 00:00:00

abstract：:Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a pandemic. Although pulmonary health has been the primary focus of studies during the early days of COVID-19, development of a comprehensive understanding of this emergent disease requi...

journal_title：Advances in wound care

authors： Singh H,Kaur H,Singh K,Sen CK

更新日期：2021-02-01 00:00:00

abstract：:Objective: Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Approach: Double transgenic mice were created by crossbreeding ...

journal_title：Advances in wound care

authors： Hu MS,Cheng J,Borrelli MR,Leavitt T,Walmsley GG,Zielins ER,Hong WX,Cheung ATM,Duscher D,Maan ZN,Irizarry DM,Stephan B,Parsa FD,Wan DC,Gurtner GC,Lorenz HP,Longaker MT

更新日期：2018-01-01 00:00:00

abstract：:Significance: Mast cells are resident inflammatory cells present in high numbers in the skin. They are one of the first cell types to respond to damage and they do so by quickly releasing a variety of preformed mediators that are stored within mast cell granules. Mast cells are not only active early on, where they hel...

journal_title：Advances in wound care

authors： Wilgus TA,Wulff BC

更新日期：2014-04-01 00:00:00