In Vitro and Ex Vivo Models for Functional Testing of Therapeutic Anti-scarring Drug Targets in Keloids.

abstract：:WOUND CARE STAKEHOLDERS SHOULD REMEMBER THAT MEDICARE REIMBURSEMENT REQUIRES THREE PARTS: a relevant code, a published Medicare payment rate, and positive coverage or coverage based upon medical necessity. Qualified healthcare professionals, scientists, and manufacturers should establish a monthly routine, where they ...

journal_title：Advances in wound care

authors： Schaum KD

更新日期：2013-12-01 00:00:00

abstract：:Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...

journal_title：Advances in wound care

authors： Hopkinson SB,Hamill KJ,Wu Y,Eisenberg JL,Hiroyasu S,Jones JC

更新日期：2014-03-01 00:00:00

abstract：:Introduction: Chronic wounds that are difficult to heal are physical and financial burden to the sufferer and a challenge to the treating physician. Objective: The main purpose of this study was to develop a novel method of using bone marrow (BM) aspirate, either cultured or fresh, as early solution for healing of chr...

journal_title：Advances in wound care

authors： Gupta GJ,Karki K,Jain P,Saxena AK

更新日期：2017-04-01 00:00:00

abstract：:Significance: Mast cells are resident inflammatory cells present in high numbers in the skin. They are one of the first cell types to respond to damage and they do so by quickly releasing a variety of preformed mediators that are stored within mast cell granules. Mast cells are not only active early on, where they hel...

journal_title：Advances in wound care

authors： Wilgus TA,Wulff BC

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has changed from studying individual genes and proteins to analyzing entire genomes and proteomes. APPRO...

journal_title：Advances in wound care

authors： Bunnik EM,Le Roch KG

更新日期：2013-11-01 00:00:00

abstract：:Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb l...

journal_title：Advances in wound care

authors： Butowicz CM,Dearth CL,Hendershot BD

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Many wounds are difficult to heal because of the large, complex community of microbes present within the wound. THE PROBLEM:Classical laboratory culture methods do not provide an accurate picture of the microbial interactions or representation of microorganisms within a wound. There is an inherent bias in d...

journal_title：Advances in wound care

authors： Tatum OL,Dowd SE

更新日期：2012-06-01 00:00:00

abstract：:Objective: Full-thickness burn wounds require immediate coverage, and the primary clinical approaches comprise of skin allografts and autografts. The use of allografts is often temporary due to the antigenicity of allografts. In contrast, the availability of skin autografts may be limited in large burn injuries. In su...

journal_title：Advances in wound care

authors： Pourghadiri A,Alnojeidi H,Jalili R,Kilani RT,Nabai L,Ghahary A

更新日期：2020-05-28 00:00:00

abstract：:Objective: The contemporary treatment of a full-thickness burn consists of early eschar excision followed by immediate closure of the open wound using autologous skin. However, most animal models study burn wound healing with the persistence of the burn eschar. Our goal is to characterize a murine model of burn eschar...

journal_title：Advances in wound care

authors： Wu JC,Rose LF,Christy RJ,Leung KP,Chan RK

更新日期：2015-02-01 00:00:00

abstract：:Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, wh...

journal_title：Advances in wound care

authors： D'Arpa P,Leung KP

更新日期：2017-10-01 00:00:00

abstract：:Significance: Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity. Compared to this benchmark, all postnatal wound healing is impaired and characterized by scar formation. The biologic basis of the fetal regenerative phenotype can serve as a road...

journal_title：Advances in wound care

authors： Balaji S,Watson CL,Ranjan R,King A,Bollyky PL,Keswani SG

更新日期：2015-11-01 00:00:00

abstract：:Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressi...

journal_title：Advances in wound care

authors： Bohn G,Liden B,Schultz G,Yang Q,Gibson DJ

更新日期：2016-01-01 00:00:00

abstract：:Rationale: The Tight Skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of human disease, including tight skin, excessive collagen deposition, alterations in the extracellular matrix (ECM), increased elastic fibers, and occurrence of antinuclear antibodies with age. A tight skin phenotype is obser...

journal_title：Advances in wound care

authors： Long KB,Burgwin CM,Huneke R,Artlett CM,Blankenhorn EP

更新日期：2014-09-01 00:00:00

abstract：:Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...

journal_title：Advances in wound care

authors： Weigelt MA,McNamara SA,Sanchez D,Hirt PA,Kirsner RS

更新日期：2021-01-01 00:00:00

abstract：SIGNIFICANCE:Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a basic science and pre-clinical perspective, seems ideal for the therapeutic stimulation of blood ves...

journal_title：Advances in wound care

authors： Wietecha MS,DiPietro LA

更新日期：2013-04-01 00:00:00

abstract：SIGNIFICANCE:Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound healing has included the use of EGF. In addition, EGFR inhibitors (EGFRis) have become a therapeutic opti...

journal_title：Advances in wound care

authors： Bodnar RJ

更新日期：2013-02-01 00:00:00

abstract：:Objective: To determine the utility of instillation negative pressure wound therapy (NPWT) in achieving eradication of infection and definitive wound closure in patients with infected left ventricular assist device (LVAD). Approach: A retrospective review was performed in a series of patients with infected and exposed...

journal_title：Advances in wound care

authors： Hodson T,West JM,Poteet SJ,Lee PH,Valerio IL

更新日期：2019-03-01 00:00:00

abstract：:Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance ...

journal_title：Advances in wound care

authors： Ganesh K,Sinha M,Mathew-Steiner SS,Das A,Roy S,Sen CK

更新日期：2015-07-01 00:00:00

abstract：:Significance: Revealing the basic mechanisms in the healing process and then regulating these processes for faster healing or to avoid negative outcomes such as infection or scarring are fundamental to wound research. The normal healing process is basically known, but to thoroughly understand the very complex aspects ...

journal_title：Advances in wound care

authors： Nuutila K,Katayama S,Vuola J,Kankuri E

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Oxygen is vital for healing wounds. It is intricately involved in numerous biological processes including cell proliferation, angiogenesis, and protein synthesis, which are required for restoration of tissue function and integrity. Adequate wound tissue oxygenation can trigger healing responses and favorably...

journal_title：Advances in wound care

authors： Castilla DM,Liu ZJ,Velazquez OC

更新日期：2012-12-01 00:00:00

abstract：:Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review...

journal_title：Advances in wound care

authors： Ho J,Walsh C,Yue D,Dardik A,Cheema U

更新日期：2017-06-01 00:00:00

abstract：:Objective: Exposure to ultraviolet (UV) light from the sun is known to accelerate the skin aging process and leads to significant alterations in skin biomechanics; however, the molecular mechanisms by which chronic UVB affects biomechanical properties of the skin have not been well described. Approach: A murine model ...

journal_title：Advances in wound care

authors： Blackstone BN,Wilgus TA,Roy S,Wulff BC,Powell HM

更新日期：2020-03-01 00:00:00

abstract：SIGNIFICANCE:Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have a significant impact on the quality of life of the patient, particularly where function and appeara...

journal_title：Advances in wound care

authors： Sharpe JR,Martin Y

更新日期：2013-05-01 00:00:00

abstract：:Significance: Bacterial burden is believed to play a significant role in impaired wound healing of chronic wounds and the development of infection-related complications. The standard of care in the clinic relies upon cultivation-dependent methods to identify microorganisms. These assays are biased toward microorganism...

journal_title：Advances in wound care

authors： Misic AM,Gardner SE,Grice EA

更新日期：2014-07-01 00:00:00

abstract：:Objective: Epidermal CD34+ stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34+ cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healin...

journal_title：Advances in wound care

authors： Li S,Hu M,Lorenz HP

更新日期：2020-05-01 00:00:00

abstract：SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...

journal_title：Advances in wound care

authors： Balaji S,King A,Crombleholme TM,Keswani SG

更新日期：2013-07-01 00:00:00

abstract：:Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...

journal_title：Advances in wound care

authors： Foubert P,Gonzalez AD,Teodosescu S,Berard F,Doyle-Eisele M,Yekkala K,Tenenhaus M,Fraser JK

更新日期：2016-07-01 00:00:00

abstract：PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...

journal_title：Advances in wound care

authors： O'Connell SM,Hessler K,Dardik H

更新日期：2012-02-01 00:00:00

abstract：:Objective: To inform on the interim results of the Remede d'Or study, which is a prospective, multicenter, single-blind, randomized, controlled clinical study on the safety and efficacy of RMD-G1, a topical carbopol-based hydrogel with a fibronectin matrix whose active pharmaceutical ingredient is erythropoietin (EPO)...

journal_title：Advances in wound care

authors： Hamed S,Belokopytov M,Ullmann Y,Safadi M,Stark Y,Shoufani A,Akita S,Liu PY,Teot L

更新日期：2019-10-01 00:00:00

abstract：:Significance: Pressure ulcers (PUs) in newborns and children are remarkably different from those in adults, both in their possible causal factors and in the etiology and biomechanical pathways for tissue damage. Recent Advances: Pediatric muscle and fat tissue structures are overall softer than those of adults, making...

journal_title：Advances in wound care

authors： Levy A,Kopplin K,Gefen A

更新日期：2015-10-01 00:00:00