Abstract:
:Significance: Angiogenesis is an important phenomenon involved in the healing of chronic wounds, and it is mainly mediated by the release of vascular endothelial growth factor (VEGF) from endothelial cells. Electrical stimulation (ES) is a well-documented treatment used to assist the healing of chronic wounds. Due to the importance of VEGF in the healing process, and the need to know the mechanisms of action of ES involved in the process, this report aimed to determine by a literature review whether the VEGF release occurs following ES in human subjects. Recent Advances: The findings of this literature review suggest that ES releases VEGF, and this effect may be responsible for promoting angiogenesis after ES. Critical Issues: Despite the findings of this literature review on the release of VEGF by ES on wound healing are promising, a large number of studies are needed to confirm such effects. Future Directions: Further studies should be conducted to identify the best parameters and treatment schedule of ES to be used for the VEGF release.
journal_name
Adv Wound Care (New Rochelle)journal_title
Advances in wound careauthors
Liebano RE,Machado AFdoi
10.1089/wound.2013.0427subject
Has Abstractpub_date
2014-02-01 00:00:00pages
98-103issue
2eissn
2162-1918issn
2162-1934pii
10.1089/wound.2013.0427journal_volume
3pub_type
评审abstract::Objective: Exposure to ultraviolet (UV) light from the sun is known to accelerate the skin aging process and leads to significant alterations in skin biomechanics; however, the molecular mechanisms by which chronic UVB affects biomechanical properties of the skin have not been well described. Approach: A murine model ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.1034
更新日期:2020-03-01 00:00:00
abstract::Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, wh...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2017.0733
更新日期:2017-10-01 00:00:00
abstract:SIGNIFICANCE:Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have a significant impact on the quality of life of the patient, particularly where function and appeara...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2012.0378
更新日期:2013-05-01 00:00:00
abstract::WOUND CARE STAKEHOLDERS SHOULD REMEMBER THAT MEDICARE REIMBURSEMENT REQUIRES THREE PARTS: a relevant code, a published Medicare payment rate, and positive coverage or coverage based upon medical necessity. Qualified healthcare professionals, scientists, and manufacturers should establish a monthly routine, where they ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2013.0498
更新日期:2013-12-01 00:00:00
abstract::Objective: To investigate the caring burden and its determinants of primary informal caregiver of patients with chronic wound. Approach: A prospective cross-sectional study of 132 pairs of chronic wound care recipients and their informal caregivers was included. The characteristics of patients and their informal careg...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0873
更新日期:2019-09-01 00:00:00
abstract::Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressi...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2015.0660
更新日期:2016-01-01 00:00:00
abstract:SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2012.0398
更新日期:2013-07-01 00:00:00
abstract::Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2016.0723
更新日期:2017-06-01 00:00:00
abstract::It was once common practice in the treatment of breast cancer for total mastectomy and axillary lymph node dissection to be conventionally performed. However, breast-conserving surgery is increasingly being performed with marked improvement in a multidisciplinary treatment approach, including surgery, chemotherapy, ir...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2012.0404
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Many wounds are difficult to heal because of the large, complex community of microbes present within the wound. THE PROBLEM:Classical laboratory culture methods do not provide an accurate picture of the microbial interactions or representation of microorganisms within a wound. There is an inherent bias in d...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2011.0303
更新日期:2012-06-01 00:00:00
abstract::Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2020.1193
更新日期:2021-01-01 00:00:00
abstract::Objective: Activation of epidermal stem cells (EpSCs) from their quiescent niche is an integral component of wound reepithelialization and involves Wnt/β-catenin (β-Cat) signaling and remodeling of the actin cytoskeleton. The aim of this study was to investigate the effect of Flightless I (Flii), a cytoskeletal protei...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0884
更新日期:2020-04-01 00:00:00
abstract::Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2013.0489
更新日期:2014-03-01 00:00:00
abstract::Objective: Full-thickness burn wounds require immediate coverage, and the primary clinical approaches comprise of skin allografts and autografts. The use of allografts is often temporary due to the antigenicity of allografts. In contrast, the availability of skin autografts may be limited in large burn injuries. In su...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.1108
更新日期:2020-05-28 00:00:00
abstract::The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2015.0653
更新日期:2016-10-01 00:00:00
abstract::Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.0970
更新日期:2019-11-01 00:00:00
abstract::Significance: Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity. Compared to this benchmark, all postnatal wound healing is impaired and characterized by scar formation. The biologic basis of the fetal regenerative phenotype can serve as a road...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2014.0564
更新日期:2015-11-01 00:00:00
abstract::Significance: Chronic skin ulcers, including venous, diabetic, and pressure ulcers, constitute a major health care burden, affecting 2-6 million people in the United States alone, with projected increases in incidence owing to the aging population and rising epidemic of diabetes. The ulcers are often accompanied by pa...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2018.0866
更新日期:2019-04-01 00:00:00
abstract:SIGNIFICANCE:Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound healing has included the use of EGF. In addition, EGFR inhibitors (EGFRis) have become a therapeutic opti...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2011.0326
更新日期:2013-02-01 00:00:00
abstract::Objective: Epidermal CD34+ stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34+ cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healin...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.0974
更新日期:2020-05-01 00:00:00
abstract:PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2011.0290
更新日期:2012-02-01 00:00:00
abstract::Introduction: Chronic wounds that are difficult to heal are physical and financial burden to the sufferer and a challenge to the treating physician. Objective: The main purpose of this study was to develop a novel method of using bone marrow (BM) aspirate, either cultured or fresh, as early solution for healing of chr...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2016.0704
更新日期:2017-04-01 00:00:00
abstract::Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0844
更新日期:2019-07-01 00:00:00
abstract::Significance: For over 30 years, there has been sustained interest in the development of mathematical models for investigating the complex mechanisms underlying each stage of the wound healing process. Despite the immense associated challenges, such models have helped usher in a paradigm shift in wound healing researc...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2019.1132
更新日期:2020-09-11 00:00:00
abstract::Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach ...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2017.0752
更新日期:2018-05-01 00:00:00
abstract::Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2018.0931
更新日期:2019-08-01 00:00:00
abstract:SIGNIFICANCE:Proteases and their inhibitors contribute to the balance between extracellular matrix (ECM) degradation and deposition, creating an equilibrium that is essential for the timely and coordinated healing of cutaneous wounds. However, when this balance is disrupted, wounds are led into a state of chronicity ch...
journal_title:Advances in wound care
pub_type: 评审
doi:10.1089/wound.2012.0370
更新日期:2013-10-01 00:00:00
abstract::Objective: To inform on the interim results of the Remede d'Or study, which is a prospective, multicenter, single-blind, randomized, controlled clinical study on the safety and efficacy of RMD-G1, a topical carbopol-based hydrogel with a fibronectin matrix whose active pharmaceutical ingredient is erythropoietin (EPO)...
journal_title:Advances in wound care
pub_type: 新闻
doi:10.1089/wound.2018.0808
更新日期:2019-10-01 00:00:00
abstract::Objective: To investigate the safety, feasibility, and acceptability of a novel treatment, intermittent electrical stimulation (IES), for preventing deep tissue injury (DTI) in different healthcare settings. Approach: Testing was conducted in an acute rehabilitation unit of a general hospital, a tertiary rehabilitatio...
journal_title:Advances in wound care
pub_type: 杂志文章
doi:10.1089/wound.2014.0569
更新日期:2015-03-01 00:00:00
abstract::Significance: Pressure ulcers (PUs) in newborns and children are remarkably different from those in adults, both in their possible causal factors and in the etiology and biomechanical pathways for tissue damage. Recent Advances: Pediatric muscle and fat tissue structures are overall softer than those of adults, making...
journal_title:Advances in wound care
pub_type: 杂志文章,评审
doi:10.1089/wound.2015.0639
更新日期:2015-10-01 00:00:00