Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair.

abstract：:Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb l...

journal_title：Advances in wound care

authors： Butowicz CM,Dearth CL,Hendershot BD

更新日期：2017-08-01 00:00:00

abstract：: Objective: In recent years, reticulated open-cell foam-based closed-incision negative pressure therapy (ROCF-ciNPT) has shown effectiveness in management of various postoperative incisions. These dressings consist of a skin interface layer that absorbs fluid from the skin ...

journal_title：Advances in wound care

authors： Kharkar PM,Osborne SN,Stern SL,Pleitner A,Wiencek KM,Kieswetter KM

更新日期：2020-08-01 00:00:00

abstract：:Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...

journal_title：Advances in wound care

authors： Foubert P,Gonzalez AD,Teodosescu S,Berard F,Doyle-Eisele M,Yekkala K,Tenenhaus M,Fraser JK

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Oxygen is vital for healing wounds. It is intricately involved in numerous biological processes including cell proliferation, angiogenesis, and protein synthesis, which are required for restoration of tissue function and integrity. Adequate wound tissue oxygenation can trigger healing responses and favorably...

journal_title：Advances in wound care

authors： Castilla DM,Liu ZJ,Velazquez OC

更新日期：2012-12-01 00:00:00

abstract：:Objective: Full-thickness burn wounds require immediate coverage, and the primary clinical approaches comprise of skin allografts and autografts. The use of allografts is often temporary due to the antigenicity of allografts. In contrast, the availability of skin autografts may be limited in large burn injuries. In su...

journal_title：Advances in wound care

authors： Pourghadiri A,Alnojeidi H,Jalili R,Kilani RT,Nabai L,Ghahary A

更新日期：2020-05-28 00:00:00

abstract：:Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic ...

journal_title：Advances in wound care

authors： Gallegos AC,Davis MJ,Tchanque-Fossuo CN,West K,Eisentrout-Melton A,Peavy TR,Dixon RW,Patel RP,Dahle SE,Isseroff RR

更新日期：2019-11-01 00:00:00

abstract：:Objective: To merge scholarly activity into the curriculum developed for medical students electing a rotation in wound care and/or dermatology. Approach: The authors adapted the unique wound care curriculum developed for medical student rotators and residents to incorporate structured scholarly projects, opportunities...

journal_title：Advances in wound care

authors： Miller S,Fulton J,Mostow E

更新日期：2014-05-01 00:00:00

abstract：SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...

journal_title：Advances in wound care

authors： Balaji S,King A,Crombleholme TM,Keswani SG

更新日期：2013-07-01 00:00:00

abstract：:Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...

journal_title：Advances in wound care

authors： Weigelt MA,McNamara SA,Sanchez D,Hirt PA,Kirsner RS

更新日期：2021-01-01 00:00:00

abstract：:It was once common practice in the treatment of breast cancer for total mastectomy and axillary lymph node dissection to be conventionally performed. However, breast-conserving surgery is increasingly being performed with marked improvement in a multidisciplinary treatment approach, including surgery, chemotherapy, ir...

journal_title：Advances in wound care

authors： Yoshimoto H,Hamuy R

更新日期：2014-01-01 00:00:00

abstract：:Objective: To determine the utility of instillation negative pressure wound therapy (NPWT) in achieving eradication of infection and definitive wound closure in patients with infected left ventricular assist device (LVAD). Approach: A retrospective review was performed in a series of patients with infected and exposed...

journal_title：Advances in wound care

authors： Hodson T,West JM,Poteet SJ,Lee PH,Valerio IL

更新日期：2019-03-01 00:00:00

abstract：:Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressi...

journal_title：Advances in wound care

authors： Bohn G,Liden B,Schultz G,Yang Q,Gibson DJ

更新日期：2016-01-01 00:00:00

abstract：:Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...

journal_title：Advances in wound care

authors： Natesan S,Stone R,Coronado RE,Wrice NL,Kowalczewski AC,Zamora DO,Christy RJ

更新日期：2019-07-01 00:00:00

abstract：:Objective: To develop a venous leg ulcer (VLU) risk stratification system for use in research and clinical practice. Approach: U.S. Wound Registry data were examined retrospectively and assigned an outcome. Bivariate analysis identified significant variables (p < 0.05) that were used to create a multivariable logistic...

journal_title：Advances in wound care

authors： Fife CE,Horn SD

更新日期：2020-02-01 00:00:00

abstract：SIGNIFICANCE:Epidermal growth factor (EGF) and EGF receptor (EGFR) play an essential role in wound healing through stimulating epidermal and dermal regeneration. The development of new therapies for enhancing wound healing has included the use of EGF. In addition, EGFR inhibitors (EGFRis) have become a therapeutic opti...

journal_title：Advances in wound care

authors： Bodnar RJ

更新日期：2013-02-01 00:00:00

abstract：SIGNIFICANCE:Proteases and their inhibitors contribute to the balance between extracellular matrix (ECM) degradation and deposition, creating an equilibrium that is essential for the timely and coordinated healing of cutaneous wounds. However, when this balance is disrupted, wounds are led into a state of chronicity ch...

journal_title：Advances in wound care

authors： McCarty SM,Percival SL

更新日期：2013-10-01 00:00:00

abstract：SIGNIFICANCE:Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a basic science and pre-clinical perspective, seems ideal for the therapeutic stimulation of blood ves...

journal_title：Advances in wound care

authors： Wietecha MS,DiPietro LA

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Adipose tissue is one of the richest sources of mesenchymal stem cells that exhibit an outstanding ability to regenerate skin. THE PROBLEM:Although the anatomical sites of adipose-derived stem cells (ASCs) in the body are relatively oxygen-deficient (i.e., 1%-5% oxygen content), ASCs are usually cultured un...

journal_title：Advances in wound care

authors： Kim WS,Sung JH

更新日期：2012-08-01 00:00:00

abstract：:Significance: Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity. Compared to this benchmark, all postnatal wound healing is impaired and characterized by scar formation. The biologic basis of the fetal regenerative phenotype can serve as a road...

journal_title：Advances in wound care

authors： Balaji S,Watson CL,Ranjan R,King A,Bollyky PL,Keswani SG

更新日期：2015-11-01 00:00:00

abstract：:The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...

journal_title：Advances in wound care

authors： Jeffery SL

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has changed from studying individual genes and proteins to analyzing entire genomes and proteomes. APPRO...

journal_title：Advances in wound care

authors： Bunnik EM,Le Roch KG

更新日期：2013-11-01 00:00:00

abstract：:Significance: Angiogenesis is an important phenomenon involved in the healing of chronic wounds, and it is mainly mediated by the release of vascular endothelial growth factor (VEGF) from endothelial cells. Electrical stimulation (ES) is a well-documented treatment used to assist the healing of chronic wounds. Due to ...

journal_title：Advances in wound care

authors： Liebano RE,Machado AF

更新日期：2014-02-01 00:00:00

abstract：:Significance: Nutrition is one of the most basic of medical issues and is often ignored as a problem in the management of our chronic wound patients. Unfortunately, malnutrition is widespread in our geriatric patients even in nursing homes in developed countries. Attention to basic nutrition and providing appropriate ...

journal_title：Advances in wound care

authors： Molnar JA,Underdown MJ,Clark WA

更新日期：2014-11-01 00:00:00

abstract：PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...

journal_title：Advances in wound care

authors： O'Connell SM,Hessler K,Dardik H

更新日期：2012-02-01 00:00:00

abstract：:Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar wo...

journal_title：Advances in wound care

authors： Yu-Wai-Man C,Khaw PT

更新日期：2016-09-01 00:00:00

abstract：:Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach ...

journal_title：Advances in wound care

authors： van Kogelenberg S,Yue Z,Dinoro JN,Baker CS,Wallace GG

更新日期：2018-05-01 00:00:00

abstract：:Significance: Mast cells are resident inflammatory cells present in high numbers in the skin. They are one of the first cell types to respond to damage and they do so by quickly releasing a variety of preformed mediators that are stored within mast cell granules. Mast cells are not only active early on, where they hel...

journal_title：Advances in wound care

authors： Wilgus TA,Wulff BC

更新日期：2014-04-01 00:00:00

abstract：:Significance: For over 30 years, there has been sustained interest in the development of mathematical models for investigating the complex mechanisms underlying each stage of the wound healing process. Despite the immense associated challenges, such models have helped usher in a paradigm shift in wound healing researc...

journal_title：Advances in wound care

authors： Menon SN,Flegg JA

更新日期：2020-09-11 00:00:00

abstract：:WOUND CARE STAKEHOLDERS SHOULD REMEMBER THAT MEDICARE REIMBURSEMENT REQUIRES THREE PARTS: a relevant code, a published Medicare payment rate, and positive coverage or coverage based upon medical necessity. Qualified healthcare professionals, scientists, and manufacturers should establish a monthly routine, where they ...

journal_title：Advances in wound care

authors： Schaum KD

更新日期：2013-12-01 00:00:00

abstract：:Objective: To investigate the safety, feasibility, and acceptability of a novel treatment, intermittent electrical stimulation (IES), for preventing deep tissue injury (DTI) in different healthcare settings. Approach: Testing was conducted in an acute rehabilitation unit of a general hospital, a tertiary rehabilitatio...

journal_title：Advances in wound care

authors： Ahmetović A,Mushahwar VK,Sommer R,Schnepf D,Kawasaki L,Warwaruk-Rogers R,Barlott T,Chong SL,Isaacson G,Kim S,Ferguson-Pell M,Stein RB,Ho C,Dukelow S,Chan KM

更新日期：2015-03-01 00:00:00