Epidermal Growth Factor and Epidermal Growth Factor Receptor: The Yin and Yang in the Treatment of Cutaneous Wounds and Cancer.

abstract：:It was once common practice in the treatment of breast cancer for total mastectomy and axillary lymph node dissection to be conventionally performed. However, breast-conserving surgery is increasingly being performed with marked improvement in a multidisciplinary treatment approach, including surgery, chemotherapy, ir...

journal_title：Advances in wound care

authors： Yoshimoto H,Hamuy R

更新日期：2014-01-01 00:00:00

abstract：:Objective: The contemporary treatment of a full-thickness burn consists of early eschar excision followed by immediate closure of the open wound using autologous skin. However, most animal models study burn wound healing with the persistence of the burn eschar. Our goal is to characterize a murine model of burn eschar...

journal_title：Advances in wound care

authors： Wu JC,Rose LF,Christy RJ,Leung KP,Chan RK

更新日期：2015-02-01 00:00:00

abstract：:Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...

journal_title：Advances in wound care

authors： Natesan S,Stone R,Coronado RE,Wrice NL,Kowalczewski AC,Zamora DO,Christy RJ

更新日期：2019-07-01 00:00:00

abstract：:Objective: Exposure to ultraviolet (UV) light from the sun is known to accelerate the skin aging process and leads to significant alterations in skin biomechanics; however, the molecular mechanisms by which chronic UVB affects biomechanical properties of the skin have not been well described. Approach: A murine model ...

journal_title：Advances in wound care

authors： Blackstone BN,Wilgus TA,Roy S,Wulff BC,Powell HM

更新日期：2020-03-01 00:00:00

abstract：:Rationale: The Tight Skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of human disease, including tight skin, excessive collagen deposition, alterations in the extracellular matrix (ECM), increased elastic fibers, and occurrence of antinuclear antibodies with age. A tight skin phenotype is obser...

journal_title：Advances in wound care

authors： Long KB,Burgwin CM,Huneke R,Artlett CM,Blankenhorn EP

更新日期：2014-09-01 00:00:00

abstract：:Significance: Pressure ulcers (PUs) in newborns and children are remarkably different from those in adults, both in their possible causal factors and in the etiology and biomechanical pathways for tissue damage. Recent Advances: Pediatric muscle and fat tissue structures are overall softer than those of adults, making...

journal_title：Advances in wound care

authors： Levy A,Kopplin K,Gefen A

更新日期：2015-10-01 00:00:00

abstract：:Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance ...

journal_title：Advances in wound care

authors： Ganesh K,Sinha M,Mathew-Steiner SS,Das A,Roy S,Sen CK

更新日期：2015-07-01 00:00:00

abstract：:Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic ...

journal_title：Advances in wound care

authors： Gallegos AC,Davis MJ,Tchanque-Fossuo CN,West K,Eisentrout-Melton A,Peavy TR,Dixon RW,Patel RP,Dahle SE,Isseroff RR

更新日期：2019-11-01 00:00:00

abstract：SIGNIFICANCE:Proteases and their inhibitors contribute to the balance between extracellular matrix (ECM) degradation and deposition, creating an equilibrium that is essential for the timely and coordinated healing of cutaneous wounds. However, when this balance is disrupted, wounds are led into a state of chronicity ch...

journal_title：Advances in wound care

authors： McCarty SM,Percival SL

更新日期：2013-10-01 00:00:00

abstract：:Significance: Keloids are benign fibro-proliferative raised dermal lesions that spread beyond the original borders of the wound, continue to grow, rarely regress, and are the most common in pigmented individuals after an abnormal wound healing response. The current treatment failure and respective challenges involved ...

journal_title：Advances in wound care

authors： Sharma JR,Lebeko M,Kidzeru EB,Khumalo NP,Bayat A

更新日期：2019-12-01 00:00:00

abstract：:Objective: Activation of epidermal stem cells (EpSCs) from their quiescent niche is an integral component of wound reepithelialization and involves Wnt/β-catenin (β-Cat) signaling and remodeling of the actin cytoskeleton. The aim of this study was to investigate the effect of Flightless I (Flii), a cytoskeletal protei...

journal_title：Advances in wound care

authors： Yang GN,Strudwick XL,Bonder C,Kopecki Z,Cowin AJ

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Oxygen is vital for healing wounds. It is intricately involved in numerous biological processes including cell proliferation, angiogenesis, and protein synthesis, which are required for restoration of tissue function and integrity. Adequate wound tissue oxygenation can trigger healing responses and favorably...

journal_title：Advances in wound care

authors： Castilla DM,Liu ZJ,Velazquez OC

更新日期：2012-12-01 00:00:00

abstract：:Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...

journal_title：Advances in wound care

authors： Hopkinson SB,Hamill KJ,Wu Y,Eisenberg JL,Hiroyasu S,Jones JC

更新日期：2014-03-01 00:00:00

abstract：SIGNIFICANCE:Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs) contributes to re-endothelialization and augments neovascularization after ischemia and tissue injury, providing a novel therapeutic application. However, controversy exists with respect to the origin, identification, and contributio...

journal_title：Advances in wound care

authors： Balaji S,King A,Crombleholme TM,Keswani SG

更新日期：2013-07-01 00:00:00

abstract：:Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...

journal_title：Advances in wound care

authors： Weigelt MA,McNamara SA,Sanchez D,Hirt PA,Kirsner RS

更新日期：2021-01-01 00:00:00

abstract：:Significance: Nutrition is one of the most basic of medical issues and is often ignored as a problem in the management of our chronic wound patients. Unfortunately, malnutrition is widespread in our geriatric patients even in nursing homes in developed countries. Attention to basic nutrition and providing appropriate ...

journal_title：Advances in wound care

authors： Molnar JA,Underdown MJ,Clark WA

更新日期：2014-11-01 00:00:00

abstract：:Objective: To develop a venous leg ulcer (VLU) risk stratification system for use in research and clinical practice. Approach: U.S. Wound Registry data were examined retrospectively and assigned an outcome. Bivariate analysis identified significant variables (p < 0.05) that were used to create a multivariable logistic...

journal_title：Advances in wound care

authors： Fife CE,Horn SD

更新日期：2020-02-01 00:00:00

abstract：:WOUND CARE STAKEHOLDERS SHOULD REMEMBER THAT MEDICARE REIMBURSEMENT REQUIRES THREE PARTS: a relevant code, a published Medicare payment rate, and positive coverage or coverage based upon medical necessity. Qualified healthcare professionals, scientists, and manufacturers should establish a monthly routine, where they ...

journal_title：Advances in wound care

authors： Schaum KD

更新日期：2013-12-01 00:00:00

abstract：:Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar wo...

journal_title：Advances in wound care

authors： Yu-Wai-Man C,Khaw PT

更新日期：2016-09-01 00:00:00

abstract：:Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the rec...

journal_title：Advances in wound care

authors： O'Rourke BP,Kramer AH,Cao LL,Inayathullah M,Guzik H,Rajadas J,Nosanchuk JD,Sharp DJ

更新日期：2019-03-01 00:00:00

abstract：:Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...

journal_title：Advances in wound care

authors： Dhall S,Hoffman T,Sathyamoorthy M,Lerch A,Jacob V,Moorman M,Kuang JQ,Danilkovitch A

更新日期：2019-08-01 00:00:00

abstract：:Chronic and hard-to-heal wounds are a tremendous burden on our healthcare system and impair the quality of life for millions of people. An emerging focus of regenerative medicine is the development of natural biomaterials that can stimulate tissue formation or repair by recreating the functional and structural propert...

journal_title：Advances in wound care

authors： Hocking DC

更新日期：2015-08-01 00:00:00

abstract：:The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...

journal_title：Advances in wound care

authors： Jeffery SL

更新日期：2016-10-01 00:00:00

abstract：SIGNIFICANCE:Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a basic science and pre-clinical perspective, seems ideal for the therapeutic stimulation of blood ves...

journal_title：Advances in wound care

authors： Wietecha MS,DiPietro LA

更新日期：2013-04-01 00:00:00

abstract：PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...

journal_title：Advances in wound care

authors： O'Connell SM,Hessler K,Dardik H

更新日期：2012-02-01 00:00:00

abstract：:Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressi...

journal_title：Advances in wound care

authors： Bohn G,Liden B,Schultz G,Yang Q,Gibson DJ

更新日期：2016-01-01 00:00:00

abstract：:Objective: Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Approach: Double transgenic mice were created by crossbreeding ...

journal_title：Advances in wound care

authors： Hu MS,Cheng J,Borrelli MR,Leavitt T,Walmsley GG,Zielins ER,Hong WX,Cheung ATM,Duscher D,Maan ZN,Irizarry DM,Stephan B,Parsa FD,Wan DC,Gurtner GC,Lorenz HP,Longaker MT

更新日期：2018-01-01 00:00:00

abstract：:Significance: Regulation of cell adhesions during tissue repair is fundamentally important for cell migration, proliferation, and protein production. All cells interact with extracellular matrix proteins with cell surface integrin receptors that convey signals from the environment into the nucleus, regulating gene exp...

journal_title：Advances in wound care

authors： Koivisto L,Heino J,Häkkinen L,Larjava H

更新日期：2014-12-01 00:00:00

abstract：:Significance: Venous leg ulcers (VLUs) are susceptible to microbial invasion, and serious complications can result without the timely control of infection. Diagnosis of wound infection is primarily based on subjective clinical characteristics and patient-reported symptoms, and the treatment with antimicrobials has not...

journal_title：Advances in wound care

authors： Tuttle MS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Adipose tissue is one of the richest sources of mesenchymal stem cells that exhibit an outstanding ability to regenerate skin. THE PROBLEM:Although the anatomical sites of adipose-derived stem cells (ASCs) in the body are relatively oxygen-deficient (i.e., 1%-5% oxygen content), ASCs are usually cultured un...

journal_title：Advances in wound care

authors： Kim WS,Sung JH

更新日期：2012-08-01 00:00:00