Full-Thickness Thermal Injury Delays Wound Closure in a Murine Model.

abstract：:Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a pandemic. Although pulmonary health has been the primary focus of studies during the early days of COVID-19, development of a comprehensive understanding of this emergent disease requi...

journal_title：Advances in wound care

authors： Singh H,Kaur H,Singh K,Sen CK

更新日期：2021-02-01 00:00:00

abstract：:Significance: Revealing the basic mechanisms in the healing process and then regulating these processes for faster healing or to avoid negative outcomes such as infection or scarring are fundamental to wound research. The normal healing process is basically known, but to thoroughly understand the very complex aspects ...

journal_title：Advances in wound care

authors： Nuutila K,Katayama S,Vuola J,Kankuri E

更新日期：2014-03-01 00:00:00

abstract：:Objective: To merge scholarly activity into the curriculum developed for medical students electing a rotation in wound care and/or dermatology. Approach: The authors adapted the unique wound care curriculum developed for medical student rotators and residents to incorporate structured scholarly projects, opportunities...

journal_title：Advances in wound care

authors： Miller S,Fulton J,Mostow E

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Many wounds are difficult to heal because of the large, complex community of microbes present within the wound. THE PROBLEM:Classical laboratory culture methods do not provide an accurate picture of the microbial interactions or representation of microorganisms within a wound. There is an inherent bias in d...

journal_title：Advances in wound care

authors： Tatum OL,Dowd SE

更新日期：2012-06-01 00:00:00

abstract：:Significance: Regulation of cell adhesions during tissue repair is fundamentally important for cell migration, proliferation, and protein production. All cells interact with extracellular matrix proteins with cell surface integrin receptors that convey signals from the environment into the nucleus, regulating gene exp...

journal_title：Advances in wound care

authors： Koivisto L,Heino J,Häkkinen L,Larjava H

更新日期：2014-12-01 00:00:00

abstract：:Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...

journal_title：Advances in wound care

authors： Weigelt MA,McNamara SA,Sanchez D,Hirt PA,Kirsner RS

更新日期：2021-01-01 00:00:00

abstract：: Objective: In recent years, reticulated open-cell foam-based closed-incision negative pressure therapy (ROCF-ciNPT) has shown effectiveness in management of various postoperative incisions. These dressings consist of a skin interface layer that absorbs fluid from the skin ...

journal_title：Advances in wound care

authors： Kharkar PM,Osborne SN,Stern SL,Pleitner A,Wiencek KM,Kieswetter KM

更新日期：2020-08-01 00:00:00

abstract：:Significance: Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity. Compared to this benchmark, all postnatal wound healing is impaired and characterized by scar formation. The biologic basis of the fetal regenerative phenotype can serve as a road...

journal_title：Advances in wound care

authors： Balaji S,Watson CL,Ranjan R,King A,Bollyky PL,Keswani SG

更新日期：2015-11-01 00:00:00

abstract：:Objective: To investigate the caring burden and its determinants of primary informal caregiver of patients with chronic wound. Approach: A prospective cross-sectional study of 132 pairs of chronic wound care recipients and their informal caregivers was included. The characteristics of patients and their informal careg...

journal_title：Advances in wound care

authors： Huang Y,Mao B,Ni P,Shou Y,Ye J,Hou L,Xie T

更新日期：2019-09-01 00:00:00

abstract：:Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review...

journal_title：Advances in wound care

authors： Ho J,Walsh C,Yue D,Dardik A,Cheema U

更新日期：2017-06-01 00:00:00

abstract：:Rationale: The Tight Skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of human disease, including tight skin, excessive collagen deposition, alterations in the extracellular matrix (ECM), increased elastic fibers, and occurrence of antinuclear antibodies with age. A tight skin phenotype is obser...

journal_title：Advances in wound care

authors： Long KB,Burgwin CM,Huneke R,Artlett CM,Blankenhorn EP

更新日期：2014-09-01 00:00:00

abstract：:Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...

journal_title：Advances in wound care

authors： Foubert P,Gonzalez AD,Teodosescu S,Berard F,Doyle-Eisele M,Yekkala K,Tenenhaus M,Fraser JK

更新日期：2016-07-01 00:00:00

abstract：:Significance: Chronic skin ulcers, including venous, diabetic, and pressure ulcers, constitute a major health care burden, affecting 2-6 million people in the United States alone, with projected increases in incidence owing to the aging population and rising epidemic of diabetes. The ulcers are often accompanied by pa...

journal_title：Advances in wound care

authors： Siadat AH,Isseroff RR

更新日期：2019-04-01 00:00:00

abstract：:Significance: Mast cells are resident inflammatory cells present in high numbers in the skin. They are one of the first cell types to respond to damage and they do so by quickly releasing a variety of preformed mediators that are stored within mast cell granules. Mast cells are not only active early on, where they hel...

journal_title：Advances in wound care

authors： Wilgus TA,Wulff BC

更新日期：2014-04-01 00:00:00

abstract：:Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, wh...

journal_title：Advances in wound care

authors： D'Arpa P,Leung KP

更新日期：2017-10-01 00:00:00

abstract：:Significance: Bacterial burden is believed to play a significant role in impaired wound healing of chronic wounds and the development of infection-related complications. The standard of care in the clinic relies upon cultivation-dependent methods to identify microorganisms. These assays are biased toward microorganism...

journal_title：Advances in wound care

authors： Misic AM,Gardner SE,Grice EA

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has changed from studying individual genes and proteins to analyzing entire genomes and proteomes. APPRO...

journal_title：Advances in wound care

authors： Bunnik EM,Le Roch KG

更新日期：2013-11-01 00:00:00

abstract：:Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach ...

journal_title：Advances in wound care

authors： van Kogelenberg S,Yue Z,Dinoro JN,Baker CS,Wallace GG

更新日期：2018-05-01 00:00:00

abstract：:Chronic and hard-to-heal wounds are a tremendous burden on our healthcare system and impair the quality of life for millions of people. An emerging focus of regenerative medicine is the development of natural biomaterials that can stimulate tissue formation or repair by recreating the functional and structural propert...

journal_title：Advances in wound care

authors： Hocking DC

更新日期：2015-08-01 00:00:00

abstract：:The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...

journal_title：Advances in wound care

authors： Jeffery SL

更新日期：2016-10-01 00:00:00

abstract：:Significance: Angiogenesis is an important phenomenon involved in the healing of chronic wounds, and it is mainly mediated by the release of vascular endothelial growth factor (VEGF) from endothelial cells. Electrical stimulation (ES) is a well-documented treatment used to assist the healing of chronic wounds. Due to ...

journal_title：Advances in wound care

authors： Liebano RE,Machado AF

更新日期：2014-02-01 00:00:00

abstract：:Significance: Nutrition is one of the most basic of medical issues and is often ignored as a problem in the management of our chronic wound patients. Unfortunately, malnutrition is widespread in our geriatric patients even in nursing homes in developed countries. Attention to basic nutrition and providing appropriate ...

journal_title：Advances in wound care

authors： Molnar JA,Underdown MJ,Clark WA

更新日期：2014-11-01 00:00:00

abstract：PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...

journal_title：Advances in wound care

authors： O'Connell SM,Hessler K,Dardik H

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Adipose tissue is one of the richest sources of mesenchymal stem cells that exhibit an outstanding ability to regenerate skin. THE PROBLEM:Although the anatomical sites of adipose-derived stem cells (ASCs) in the body are relatively oxygen-deficient (i.e., 1%-5% oxygen content), ASCs are usually cultured un...

journal_title：Advances in wound care

authors： Kim WS,Sung JH

更新日期：2012-08-01 00:00:00

abstract：:Significance: Keloids are benign fibro-proliferative raised dermal lesions that spread beyond the original borders of the wound, continue to grow, rarely regress, and are the most common in pigmented individuals after an abnormal wound healing response. The current treatment failure and respective challenges involved ...

journal_title：Advances in wound care

authors： Sharma JR,Lebeko M,Kidzeru EB,Khumalo NP,Bayat A

更新日期：2019-12-01 00:00:00

abstract：:Significance: Venous leg ulcers (VLUs) are susceptible to microbial invasion, and serious complications can result without the timely control of infection. Diagnosis of wound infection is primarily based on subjective clinical characteristics and patient-reported symptoms, and the treatment with antimicrobials has not...

journal_title：Advances in wound care

authors： Tuttle MS

更新日期：2015-01-01 00:00:00

abstract：:Significance: Pressure ulcers (PUs) in newborns and children are remarkably different from those in adults, both in their possible causal factors and in the etiology and biomechanical pathways for tissue damage. Recent Advances: Pediatric muscle and fat tissue structures are overall softer than those of adults, making...

journal_title：Advances in wound care

authors： Levy A,Kopplin K,Gefen A

更新日期：2015-10-01 00:00:00

abstract：:Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...

journal_title：Advances in wound care

authors： Dhall S,Hoffman T,Sathyamoorthy M,Lerch A,Jacob V,Moorman M,Kuang JQ,Danilkovitch A

更新日期：2019-08-01 00:00:00

abstract：SIGNIFICANCE:Re-establishment of a functional vascular network is a critical component of successful wound repair. One of the most potent pro-angiogenic agents is vascular endothelial growth factor (VEGF), which, from a basic science and pre-clinical perspective, seems ideal for the therapeutic stimulation of blood ves...

journal_title：Advances in wound care

authors： Wietecha MS,DiPietro LA

更新日期：2013-04-01 00:00:00

abstract：:Objective: To develop a cost-effective and clinically usable therapy to treat full-thickness skin injuries. We accomplished this by preparing a viscoelastic hydrogel using polyethylene glycol (PEG)-modified platelet-free plasma (PEGylated PFP) combined with human adipose-derived stem cells (ASCs). Approach: PEGylated ...

journal_title：Advances in wound care

authors： Natesan S,Stone R,Coronado RE,Wrice NL,Kowalczewski AC,Zamora DO,Christy RJ

更新日期：2019-07-01 00:00:00