Skin Biomechanics and miRNA Expression Following Chronic UVB Irradiation.

abstract：:Objective: Wound healing is a complex process involving the dynamic interplay of various types of cells and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of the process, resulting in non-healing chronic wounds. Human amniotic membrane (AM) has been shown to be effective in the...

journal_title：Advances in wound care

authors： Dhall S,Hoffman T,Sathyamoorthy M,Lerch A,Jacob V,Moorman M,Kuang JQ,Danilkovitch A

更新日期：2019-08-01 00:00:00

abstract：:Rationale: The Tight Skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of human disease, including tight skin, excessive collagen deposition, alterations in the extracellular matrix (ECM), increased elastic fibers, and occurrence of antinuclear antibodies with age. A tight skin phenotype is obser...

journal_title：Advances in wound care

authors： Long KB,Burgwin CM,Huneke R,Artlett CM,Blankenhorn EP

更新日期：2014-09-01 00:00:00

abstract：:Significance: Broad-spectrum metalloproteinase (MMP) reduction along with inherent aspects of an extracellular matrix (ECM) dressing can bring about improved wound healing outcomes and shorter treatment duration. Initial reports of clinical effectiveness of a new ovine-based collagen extracellular matrix (CECM) dressi...

journal_title：Advances in wound care

authors： Bohn G,Liden B,Schultz G,Yang Q,Gibson DJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Oxygen is vital for healing wounds. It is intricately involved in numerous biological processes including cell proliferation, angiogenesis, and protein synthesis, which are required for restoration of tissue function and integrity. Adequate wound tissue oxygenation can trigger healing responses and favorably...

journal_title：Advances in wound care

authors： Castilla DM,Liu ZJ,Velazquez OC

更新日期：2012-12-01 00:00:00

abstract：:Significance: Regulation of cell adhesions during tissue repair is fundamentally important for cell migration, proliferation, and protein production. All cells interact with extracellular matrix proteins with cell surface integrin receptors that convey signals from the environment into the nucleus, regulating gene exp...

journal_title：Advances in wound care

authors： Koivisto L,Heino J,Häkkinen L,Larjava H

更新日期：2014-12-01 00:00:00

abstract：:Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb l...

journal_title：Advances in wound care

authors： Butowicz CM,Dearth CL,Hendershot BD

更新日期：2017-08-01 00:00:00

abstract：:Introduction: Chronic wounds that are difficult to heal are physical and financial burden to the sufferer and a challenge to the treating physician. Objective: The main purpose of this study was to develop a novel method of using bone marrow (BM) aspirate, either cultured or fresh, as early solution for healing of chr...

journal_title：Advances in wound care

authors： Gupta GJ,Karki K,Jain P,Saxena AK

更新日期：2017-04-01 00:00:00

abstract：:Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach ...

journal_title：Advances in wound care

authors： van Kogelenberg S,Yue Z,Dinoro JN,Baker CS,Wallace GG

更新日期：2018-05-01 00:00:00

abstract：:Significance: Biofilms in vivo are small densely packed aggregations of microbes that are highly resistant to host immune responses and treatment. They attach to each other and to nearby surfaces. Biofilms are difficult to study and identify in a clinical setting as their quantification necessitates the use of advance...

journal_title：Advances in wound care

authors： Weigelt MA,McNamara SA,Sanchez D,Hirt PA,Kirsner RS

更新日期：2021-01-01 00:00:00

abstract：:Significance: Chronic skin ulcers, including venous, diabetic, and pressure ulcers, constitute a major health care burden, affecting 2-6 million people in the United States alone, with projected increases in incidence owing to the aging population and rising epidemic of diabetes. The ulcers are often accompanied by pa...

journal_title：Advances in wound care

authors： Siadat AH,Isseroff RR

更新日期：2019-04-01 00:00:00

abstract：:Significance: Bacterial burden is believed to play a significant role in impaired wound healing of chronic wounds and the development of infection-related complications. The standard of care in the clinic relies upon cultivation-dependent methods to identify microorganisms. These assays are biased toward microorganism...

journal_title：Advances in wound care

authors： Misic AM,Gardner SE,Grice EA

更新日期：2014-07-01 00:00:00

abstract：:WOUND CARE STAKEHOLDERS SHOULD REMEMBER THAT MEDICARE REIMBURSEMENT REQUIRES THREE PARTS: a relevant code, a published Medicare payment rate, and positive coverage or coverage based upon medical necessity. Qualified healthcare professionals, scientists, and manufacturers should establish a monthly routine, where they ...

journal_title：Advances in wound care

authors： Schaum KD

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Adipose tissue is one of the richest sources of mesenchymal stem cells that exhibit an outstanding ability to regenerate skin. THE PROBLEM:Although the anatomical sites of adipose-derived stem cells (ASCs) in the body are relatively oxygen-deficient (i.e., 1%-5% oxygen content), ASCs are usually cultured un...

journal_title：Advances in wound care

authors： Kim WS,Sung JH

更新日期：2012-08-01 00:00:00

abstract：PROBLEM:Lower extremity ulcers (venous, diabetic) are often unresponsive to standard treatment. Various systemic and local cellular, vascular, and anatomical factors can result in nonhealing wounds that are refractory to normal healing processes and standard care. SOLUTION:Several published wound care guidelines stron...

journal_title：Advances in wound care

authors： O'Connell SM,Hessler K,Dardik H

更新日期：2012-02-01 00:00:00

abstract：:Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the rec...

journal_title：Advances in wound care

authors： O'Rourke BP,Kramer AH,Cao LL,Inayathullah M,Guzik H,Rajadas J,Nosanchuk JD,Sharp DJ

更新日期：2019-03-01 00:00:00

abstract：:Significance: Multispecies microbial biofilms may contribute to wound chronicity by derailing the inherent reparative process of the host tissue. In the biofilm form, bacteria are encased within an extracellular polymeric substance and become recalcitrant to antimicrobials and host defenses. For biofilms of relevance ...

journal_title：Advances in wound care

authors： Ganesh K,Sinha M,Mathew-Steiner SS,Das A,Roy S,Sen CK

更新日期：2015-07-01 00:00:00

abstract：:The concept of the military wound is not an easy entity to define as the wounds seen in conflict can be of many types: those caused by recognized or improvised weapon systems may have similarities to civilian wounds as well as the wounds soldiers sustain outside of battle. This article will focus on the current treatm...

journal_title：Advances in wound care

authors： Jeffery SL

更新日期：2016-10-01 00:00:00

abstract：:Chronic and hard-to-heal wounds are a tremendous burden on our healthcare system and impair the quality of life for millions of people. An emerging focus of regenerative medicine is the development of natural biomaterials that can stimulate tissue formation or repair by recreating the functional and structural propert...

journal_title：Advances in wound care

authors： Hocking DC

更新日期：2015-08-01 00:00:00

abstract：:Objective: Activation of epidermal stem cells (EpSCs) from their quiescent niche is an integral component of wound reepithelialization and involves Wnt/β-catenin (β-Cat) signaling and remodeling of the actin cytoskeleton. The aim of this study was to investigate the effect of Flightless I (Flii), a cytoskeletal protei...

journal_title：Advances in wound care

authors： Yang GN,Strudwick XL,Bonder C,Kopecki Z,Cowin AJ

更新日期：2020-04-01 00:00:00

abstract：:Objective: Epidermal CD34+ stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34+ cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healin...

journal_title：Advances in wound care

authors： Li S,Hu M,Lorenz HP

更新日期：2020-05-01 00:00:00

abstract：:Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode of administration remain unclear. The purpose of this study was to comp...

journal_title：Advances in wound care

authors： Foubert P,Gonzalez AD,Teodosescu S,Berard F,Doyle-Eisele M,Yekkala K,Tenenhaus M,Fraser JK

更新日期：2016-07-01 00:00:00

abstract：:Significance: Revealing the basic mechanisms in the healing process and then regulating these processes for faster healing or to avoid negative outcomes such as infection or scarring are fundamental to wound research. The normal healing process is basically known, but to thoroughly understand the very complex aspects ...

journal_title：Advances in wound care

authors： Nuutila K,Katayama S,Vuola J,Kankuri E

更新日期：2014-03-01 00:00:00

abstract：:Objective: To investigate the caring burden and its determinants of primary informal caregiver of patients with chronic wound. Approach: A prospective cross-sectional study of 132 pairs of chronic wound care recipients and their informal caregivers was included. The characteristics of patients and their informal careg...

journal_title：Advances in wound care

authors： Huang Y,Mao B,Ni P,Shou Y,Ye J,Hou L,Xie T

更新日期：2019-09-01 00:00:00

abstract：:Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a pandemic. Although pulmonary health has been the primary focus of studies during the early days of COVID-19, development of a comprehensive understanding of this emergent disease requi...

journal_title：Advances in wound care

authors： Singh H,Kaur H,Singh K,Sen CK

更新日期：2021-02-01 00:00:00

abstract：:Objective: Splinting full-thickness cutaneous wounds in mice has allowed for a humanized model of wound healing. Delineating the epithelial edge and assessing time to closure of these healing wounds via macroscopic visualization have remained a challenge. Approach: Double transgenic mice were created by crossbreeding ...

journal_title：Advances in wound care

authors： Hu MS,Cheng J,Borrelli MR,Leavitt T,Walmsley GG,Zielins ER,Hong WX,Cheung ATM,Duscher D,Maan ZN,Irizarry DM,Stephan B,Parsa FD,Wan DC,Gurtner GC,Lorenz HP,Longaker MT

更新日期：2018-01-01 00:00:00

abstract：:Objective: To investigate the safety, feasibility, and acceptability of a novel treatment, intermittent electrical stimulation (IES), for preventing deep tissue injury (DTI) in different healthcare settings. Approach: Testing was conducted in an acute rehabilitation unit of a general hospital, a tertiary rehabilitatio...

journal_title：Advances in wound care

authors： Ahmetović A,Mushahwar VK,Sommer R,Schnepf D,Kawasaki L,Warwaruk-Rogers R,Barlott T,Chong SL,Isaacson G,Kim S,Ferguson-Pell M,Stein RB,Ho C,Dukelow S,Chan KM

更新日期：2015-03-01 00:00:00

abstract：:Significance: Mast cells are resident inflammatory cells present in high numbers in the skin. They are one of the first cell types to respond to damage and they do so by quickly releasing a variety of preformed mediators that are stored within mast cell granules. Mast cells are not only active early on, where they hel...

journal_title：Advances in wound care

authors： Wilgus TA,Wulff BC

更新日期：2014-04-01 00:00:00

abstract：:Significance: During wound healing of the skin, keratinocytes should move over while still adhering to their underlying matrix. Thus, mechanistic insights into the wound-healing process require an understanding of the forms and functions of keratinocyte matrix adhesions, specifically focal contacts and hemidesmosomes,...

journal_title：Advances in wound care

authors： Hopkinson SB,Hamill KJ,Wu Y,Eisenberg JL,Hiroyasu S,Jones JC

更新日期：2014-03-01 00:00:00

abstract：:Objective: To inform on the interim results of the Remede d'Or study, which is a prospective, multicenter, single-blind, randomized, controlled clinical study on the safety and efficacy of RMD-G1, a topical carbopol-based hydrogel with a fibronectin matrix whose active pharmaceutical ingredient is erythropoietin (EPO)...

journal_title：Advances in wound care

authors： Hamed S,Belokopytov M,Ullmann Y,Safadi M,Stark Y,Shoufani A,Akita S,Liu PY,Teot L

更新日期：2019-10-01 00:00:00

abstract：:Significance: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths. It is well established that the eye and other tissues of some group of patients, for example Afro-Caribbean people, scar wo...

journal_title：Advances in wound care

authors： Yu-Wai-Man C,Khaw PT

更新日期：2016-09-01 00:00:00