Abstract:
:As chromatin structures, telomeres undergo epigenetic regulation of their maintenance and function. In plants, these processes are likely of a higher complexity than in animals or yeasts, as exemplified by methylation of cytosines in plant telomeric DNA or reversible developmental regulation of plant telomerase. We highlight the dual role of telomeres from the epigenetic point of view: (i) as chromatin structures that are the subject of epigenetic regulation (e.g. DNA and histone modifications), and (ii) as chromosome domains acting themselves as epigenetic regulatory elements (e.g. in the telomere position effect). Possibly, some molecular tools (e.g. telomeric transcripts) are common to both these aspects of telomere epigenetics. We further discuss the justification for the classical textbook view of telomeres as heterochromatic structures.
journal_name
Cytogenet Genome Resjournal_title
Cytogenetic and genome researchauthors
Fojtová M,Fajkus Jdoi
10.1159/000360775subject
Has Abstractpub_date
2014-01-01 00:00:00pages
125-35issue
1-3eissn
1424-8581issn
1424-859Xpii
000360775journal_volume
143pub_type
杂志文章,评审abstract::Breast cancer is a complex and heterogeneous disease, and the establishment of cell models in order to properly study the disease at the molecular and cellular level is of utmost importance. Here, we present the cytogenetic characterization and gene expression analysis of the tumoral mammary rat cell line CLS-ACI-1. T...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000441374
更新日期:2015-01-01 00:00:00
abstract::We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abo...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000336201
更新日期:2012-01-01 00:00:00
abstract::Homologous chromosome pairing and recombination are essential components of meiosis and sexual reproduction. The reshuffling of genetic material through breakage and reunion of chromatids ensure proper segregation of homologous chromosomes in reduction division and genetic diversity in the progeny. The advent of somat...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000118745
更新日期:2008-01-01 00:00:00
abstract::Genets (Genetta) are a genus of African mammalian carnivorans with 14 currently recognized species, although taxonomic uncertainties remain, particularly regarding the number of species within the large-spotted genet complex. This study presents the first banded karyotype and molecular cytogenetic analysis of a geneti...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000450627
更新日期:2016-01-01 00:00:00
abstract::The formation of heterochromatin begins in the differentiating cells. The aim of this work was to study changes of satellite DNA distribution, transcriptional activity and interaction with certain proteins in mouse embryonic stem cells after induction with retinoic acid. We found that pericentromeric satellites entere...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000218132
更新日期:2009-01-01 00:00:00
abstract::In order to contribute to the knowledge of type and frequency of chromosome abnormalities in early pregnancy losses, we analyzed the cytogenetic results from a large series of first trimester miscarriages, using a diagnostic approach with a high success rate and no maternal contamination. A total of 1,119 consecutive ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000477707
更新日期:2017-01-01 00:00:00
abstract::A 17-year-old girl presented with a distinct phenotype mainly featuring craniofacial dysmorphism, including a disproportioned large, round, elongated face; hypertelorism; deep-set eyes with short palpebral fissures; obesity (BMI 37), and a neuropsychiatric disorder with high-functioning autism. Postnatal conventional ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000481331
更新日期:2017-01-01 00:00:00
abstract::Fusions of the Runt-related transcription factor 1 (RUNX1) with different partner genes have been associated with various hematological disorders. Interestingly, the C-terminally truncated form of RUNX1 and RUNX1 fusion proteins are similarly considered important contributors to leukemogenesis. Here, we describe a 59-...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000508012
更新日期:2020-01-01 00:00:00
abstract::1q44 deletion is a rare syndrome associated with facial dysmorphism and developmental delay, in particular related with expressive speech, seizures, and hypotonia (ORPHA:238769). Until today, the distinct genetic causes for the different symptoms remain not entirely clear. We present a patient with a 2.3-Mb 1q44 delet...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000504424
更新日期:2019-01-01 00:00:00
abstract::Previous genetic mapping identified three linkage groups (M1, M18 and M26) in the turkey corresponding to chicken chromosome 1 (GGA1). This is inconsistent with previously described chromosomal differences between these species. FISH analysis of BAC clones corresponding to microsatellite markers from each of the three...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000095239
更新日期:2006-01-01 00:00:00
abstract::To study the origin and evolution of naturally occurring polyploids, we performed phylogenetic analyses of nuclear ribosomal DNA spacers combined with molecular cytogenetics in 55 accessions of 27 taxa of the oat genus Helictochloa. A complex pattern of reticulate evolution was revealed with many diploid species and e...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000361002
更新日期:2014-01-01 00:00:00
abstract::During the last decade not only multicolor fluorescence in situ hybridization (FISH) using whole chromosome paints as probes, but also numerous chromosome banding techniques based on FISH have been developed for the human and for the murine genome. This review focuses on such FISH-banding techniques, which were recent...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000094207
更新日期:2006-01-01 00:00:00
abstract::Aegilops mutica Boiss., a diploid species (2n = 2x = 14, TT), has been rarely studied before. In this research, a hexaploid wheat (cv. Chinese Spring)-Ae. mutica partial amphiploid and a wheat-Ae. mutica addition line were characterized by chromosome karyotyping, FISH using oligonucleotides Oligo-pTa535-1, Oligo-pSc11...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000443625
更新日期:2015-01-01 00:00:00
abstract::It is widely accepted that the H2AX histone in its phosphorylated form (gamma-H2AX) is related to the repair of DNA double-strand breaks (DSBs). In several organisms, gamma-H2AX presence has been demonstrated in meiotic processes such as recombination and sex chromosome inactivation during prophase I (from leptotene t...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000100416
更新日期:2007-01-01 00:00:00
abstract::Most human cancers are characterized by genomic instability. Changes associated with such may result in altered expression of numerous genes. The sequence information available in the public databases can be used to identify transcripts differentially expressed in cancers. Determining cancer-related genes that are com...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000087513
更新日期:2006-01-01 00:00:00
abstract::A patient with a rare interstitial deletion of chromosomal band 2q33.2q33.3 is described. The clinical features resembled the 2q33.1 microdeletion syndrome (Glass syndrome), including mental retardation, facial dysmorphism, high-arched narrow palate, growth deficiency, and speech delay. The chromosomal aberration was ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000381568
更新日期:2015-01-01 00:00:00
abstract::The INRA and the CHORI-241 horse BAC libraries were screened by hybridization with DNA probes and/or directly by PCR with primers designed in consensus sequences of genes localized at the end of each human chromosome. BAC clones were retrieved and 36 could be FISH mapped after the expected gene was confirmed in each B...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000085669
更新日期:2005-01-01 00:00:00
abstract::Translocations involving chromosomal region 19q13 are a frequent finding in follicular adenomas of the thyroid and might represent the most frequent type of structural aberration in human epithelial tumors. By positional cloning, a putative candidate gene, ZNF331 (formerly RITA) located close to the breakpoint was ide...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000074165
更新日期:2003-01-01 00:00:00
abstract::In the past few years high throughput methods for assessment of DNA copy number alterations have witnessed rapid progress. Both 'in house' developed BAC, cDNA, oligonucleotide and commercial arrays are now available and widely applied in the study of the human genome, particularly in the context of disease. Cancer cel...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000095924
更新日期:2006-01-01 00:00:00
abstract::R-banding chromosomal studies of 21 species of Lemuriformes allowed us to reconstruct the presumed ancestral karyotype of all the Lemuriformes except for Daubentoniidae and permitted the construction of their phylogenetic tree. Chromosome painting with fluorescently labeled heterologous DNA probes permitted comparativ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000080816
更新日期:2005-01-01 00:00:00
abstract::The occurrence of interchromosomal effects (ICE) in reciprocal translocation carriers still remains contradictory in the human literature. We used the pig as an animal model to investigate whether the structure of the reciprocal translocations as well as the size and/or type of the chromosomes not involved in the rear...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000245920
更新日期:2009-01-01 00:00:00
abstract::Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare, multisystemic, autosomal recessive condition typically presenting with digital clubbing, osteoarthropathy, and various skin manifestations. Radiographs show distinctive periosteal reaction and thickening along the long bones. ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000500988
更新日期:2019-01-01 00:00:00
abstract::Recently, the reticulated giraffe (G. reticulata) was identified as a distinct species, which emphasized the need for intensive research in this interesting animal. To shed light on the meiotic process as a source of biodiversity, we analysed the frequency and distribution of meiotic recombination in 2 reticulated gir...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000478684
更新日期:2017-01-01 00:00:00
abstract::ATM, the protein product of the gene mutated in the human autosomal recessive disorder ataxia telangiectasia, is involved in detection of double strand breaks (DSBs) and is a key component of the damage surveillance network of cell cycle proteins. In somatic cells ATM phosphorylates many other proteins including p53, ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000080603
更新日期:2004-01-01 00:00:00
abstract::Only mammals have relinquished parthenogenesis as a means of producing descendants. Bi-parental reproduction is necessary due to parent-specific epigenetic modification of the genome during gametogenesis, which leads to non-equivalent expression of imprinted genes from the maternal and paternal alleles. However, a ser...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000090812
更新日期:2006-01-01 00:00:00
abstract::Chromatin diminution (CD) is a phenomenon of programmed DNA elimination which takes place in early embryogenesis in some eukaryotes. The mechanism and biological role of CD remain largely unknown. During CD in the freshwater copepod Cyclops kolensis, the genome of cells of the somatic lineage is reorganized and reduce...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章,评审
doi:10.1159/000494157
更新日期:2018-01-01 00:00:00
abstract::The chromosomal band 17q21.31, containing the microtubule-associated protein tau (MAPT) gene, is a hotspot for chromosomal rearrangements. It is known to contain a common inversion polymorphism of approximately 900 kb in populations with European ancestry. The inverted configuration is linked to a distinct MAPT haplot...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000315901
更新日期:2010-01-01 00:00:00
abstract::The chromosomes and banding patterns of Steindachneridion sp., a large catfish (Pimelodidae), endemic to the Iguaçu River, Brazil, were analyzed using conventional (C-, G-banding) and restriction enzyme banding methods. The same diploid number (2n = 56) as in other members of the genus and the family was found but the...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000089888
更新日期:2006-01-01 00:00:00
abstract::Several patients with 5p duplication or 15q deletion have been reported in the literature, involving different chromosome regions and clinical features. Here, we describe a family in which we identified a 30-Mb 5p15.33p13.3 gain and a 2.5-Mb 15q26.3 loss in 3 individuals, due to a balanced familial translocation betwe...
journal_title:Cytogenetic and genome research
pub_type:
doi:10.1159/000511235
更新日期:2020-12-14 00:00:00
abstract::XIST encodes a functional RNA that is expressed exclusively from the inactive X in female mammals and is required for the silencing of most of the genes on the chromosome. XIST transcripts remain in the nucleus, and their specific localization to the inactive X is important for silencing; however, it is not known how ...
journal_title:Cytogenetic and genome research
pub_type: 杂志文章
doi:10.1159/000071579
更新日期:2002-01-01 00:00:00