Abstract:
:The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. Eighty COPD patients with pulmonary artery hypertension were selected and divided into two groups: the treatment group and the control group, which had 40 patients respectively. The control group received routine treatment, including oxygen uptake, anti-infection and phlegm dissolving. The treatment group received the Fasudil in addition to the routine treatment. The changes on the number and function of the late endothelial progenitor cells in peripheral blood of the patients before and after the treatment were compared between the two groups. The changes on the pulmonary artery pressure were also compared. The number of the late endothelial progenitor cells in peripheral blood of the treatment group increased and the function was enhanced. The pulmonary artery pressure was reduced. The difference before and after the treatment and with the control group was statistically significant (p<0.05). The changes on the number and function of the late endothelial progenitor cells in peripheral blood and the pulmonary artery pressure before and after the treatment of the control group were not statistically significant (p>0.05). The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.
journal_name
Bosn J Basic Med Scijournal_title
Bosnian journal of basic medical sciencesauthors
Liu P,Zhang H,Tang Y,Sheng C,Liu J,Zeng Ydoi
10.17305/bjbms.2014.2295subject
Has Abstractpub_date
2014-02-01 00:00:00pages
40-4issue
1eissn
1512-8601issn
1840-4812journal_volume
14pub_type
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journal_title:Bosnian journal of basic medical sciences
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pub_type: 临床试验,杂志文章
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journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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