Dishevelled family proteins (DVL1-3) expression in intrauterine growth restriction (IUGR) placentas.

Abstract:

:Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt signaling pathway during embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in naturally invasive tissue, trophoblast. Formalin-fixed paraffin-embedded samples of 15 term placentas from physiologic term pregnancies and 15 term placentas from pregnancies complicated with intrauterine growth restrictions (IUGR) were used for the study. Expression levels of mRNA for DVL1, DVL2, and DVL3 in placentas were analyzed by quantitative real-time PCR (qRTPCR). DVL1, DVL2, and DVL3 protein expression were semi-quantitatively analyzed using immunohistochemistry. The expression of DVL2 and DVL3 proteins was significantly higher in trophoblasts in placental villi from IUGR pregnancies compared with the control group of term placentas. In contrast, DVL3 protein expression was significantly higher in endothelial cells in placental villi from IUGR pregnancies compared with normal term placentas. The observed differences at protein levels between normal and IUGR placentas were not confirmed at the mRNA levels of DVL genes. Our data indicate the active involvement of DVL proteins in IUGR-related placentas. No significant changes were observed in DVL mRNA levels between the two groups of placentas. Further studies are required to explore the clinical relevance of these observations.

journal_name

Bosn J Basic Med Sci

authors

Sola IM,Serman A,Karin-Kujundzic V,Paic F,Skrtic A,Slatina P,Kakarigi L,Vranic S,Serman L

doi

10.17305/bjbms.2020.5422

subject

Has Abstract

pub_date

2020-12-26 00:00:00

eissn

1512-8601

issn

1840-4812

pub_type

杂志文章
  • Transcranial Doppler sonography as diagnostic method.

    abstract::Having in mind the fact that cerebrovascular disease (CVB) takes today in medicine, in spite of diagnostic and therapeutic modernisation, the third place of mortality causes in the world (behind cordial and malignant diseases, but in front of depressions), and the second place of invalidity cause (right after trauma) ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2002.3585

    authors: Delilović-Vranić J

    更新日期:2002-12-01 00:00:00

  • Uvulopalatopharyngoplasty and barbed reposition pharyngoplasty with and without hyoid suspension for obstructive sleep apnea hypopnea syndrome: A comparison of long-term functional results.

    abstract::Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common condition; when conservative approaches are not effective, surgical techniques aimed at reducing the airway obstruction effect are used. This retrospective study aimed at comparing the functional outcomes in patients with OSAHS undergoing uvulopalatopharyng...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4724

    authors: Minni A,Cialente F,Ralli M,Colizza A,Lai Q,Placentino A,Franco M,Rossetti V,De Vincentiis M

    更新日期:2020-04-27 00:00:00

  • Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer.

    abstract::Non-small-cell lung cancer (NSCLC) with KRAS (Kirsten RAt Sarcoma 2 viral oncogene homolog) mutation has become a clinical challenge in cancer treatment as KRAS-mutant tumors are often resistant to conventional anti-tumor therapies. Activated CDC42-associated kinase 1 (ACK1), an activator of protein kinase B (AKT), is...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4746

    authors: Yu X,Liu J,Qiu H,Hao H,Zhu J,Peng S

    更新日期:2020-06-01 00:00:00

  • MicroRNAs: Recent insights towards their role in male infertility and reproductive cancers.

    abstract::Spermatogenesis is a tightly controlled, multi-step process in which mature spermatozoa are produced. Disruption of regulatory mechanisms in spermatogenesis can lead to male infertility, various diseases of male reproductive system, or even cancer. The spermatogenic impairment in infertile men can be associated with d...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2018.3477

    authors: Khawar MB,Mehmood R,Roohi N

    更新日期:2019-02-12 00:00:00

  • Methylenetetrahydrofolate Reductase gene polymorphism in patients receiving hemodialysis.

    abstract::Methylenetetrahydrofolate Reductase (MTHFR) is key enzyme in metabolism of homocysteine. Homozygotes for mutation (TT genotype) have hyperhomocysteinemia, risk factor for atherosclerosis development. The aim of the study was to find out distribution of genotype frequencies of C677T MTHFR among patients on maintenance ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2656

    authors: Kiseljaković E,Resić H,Kapur L,Hasić S,Jadrić R

    更新日期:2010-04-01 00:00:00

  • Effects of basal insulin analog and metformin on glycaemia control and weight as risk factors for endothelial dysfunction.

    abstract::Obese patients with type 2 diabetes and impaired glucose tolerance are at increased risk of development of cardiovascular diseases. Endothelial dysfunction may be a reason for development of atherosclerosis and cardiovascular diseases. Lifestyle modification, increased physical activity, weight reduction, energy restr...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.2882

    authors: Ascić-Buturović B,Kacila M

    更新日期:2008-11-01 00:00:00

  • Extracorporeal shock waves lithotripsy versus retrograde ureteroscopy: is radiation exposure a criterion when we choose which modern treatment to apply for ureteric stones?

    abstract::The aim of this study is to compare two major urological procedures in terms of patient exposure to radiation. We evaluated 175 patients, that were subjected to retrograde ureteroscopy (URS) and extracorporeal shock waves lithotripsy (ESWL) for lumbar or pelvic ureteral lithiasis, at two urological departments. The C-...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2014.4.99

    authors: Pricop C,Maier A,Negru D,Malau O,Orsolya M,Radavoi D,Serban DR

    更新日期:2014-10-18 00:00:00

  • Neurological outcome in patients after successful resuscitation in out-of-hospital settings.

    abstract::Neurological outcome is an important determinant of death in admitted survivors after out-of-hospital cardiac arrest (OHCA). Studies demonstrated several significant pre-hospital predictors of ischemic brain injury (time to resuscitation, time of resuscitation, and cause of OHCA). Our aim was to evaluate the relations...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4623

    authors: Marinšek M,Sinkovič A,Šuran D

    更新日期:2020-08-03 00:00:00

  • Growth hormone (GH): usage and abuse.

    abstract::Growth hormone is essential for body growth but it also modulates metabolic pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary functions. Numerous beneficial effects of growth hormone have led to its expanded therapeutic use in both children and adults. There are several officially approve...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2004.3365

    authors: Hadzović A,Nakas-Ićindić E,Kucukalić-Selimović E,Salaka AU

    更新日期:2004-10-01 00:00:00

  • A three-dimensional computed tomography study to determine the ideal method for fluoroscopically-guided bone marrow aspiration from the iliac crest.

    abstract::Bone marrow aspiration (BMA) through the iliac crest is potentially unsafe due to the vicinity of neurovascular structures in the greater sciatic notch. Our objective was to investigate the safety of a recently described BMA technique, specifically a trajectory from the posterior superior iliac spine (PSIS) to the ant...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4744

    authors: D'Souza RS,Li L,Leng S,Hunt C,Law L,Muir C,Eldrige J,Bydon M,Chi M,Shapiro S,Mauck WD,Qu W

    更新日期:2020-05-11 00:00:00

  • Skin and kidney histological changes in graft-versus-host disease (GVHD) after kidney transplantation.

    abstract::Kidney transplantation (Ktx) is generally performed during end stage renal disease due to a loss of the kidneys' ability to filter wastes from the circulatory system. Acute graft-versus-host disease (GVHD) after Ktx is a life-threatening complication that progresses to organ failure, systemic complications, and death....

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2011.2594

    authors: Pintar T,Alessiani M,Pleskovič A,Pleskovič A,Zorc-Pleskovič R,Milutinović A

    更新日期:2011-05-01 00:00:00

  • Does dental caries affect dental development in children and adolescents?

    abstract::Although a link between dietary changes, caries, and dental development has been observed, the literature provides little insight about this relationship. The aim of our study was to investigate the association between dental caries and dental development in a clinical sample of Albanian children and adolescents. In t...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.2841

    authors: Dhamo B,Elezi B,Kragt L,Wolvius EB,Ongkosuwito EM

    更新日期:2018-05-20 00:00:00

  • Trends of incidence and prognosis of upper tract urothelial carcinoma.

    abstract::The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.5345

    authors: Wu J,Chen S,Wu X,Mao W,Wang Y,Xu B,Zheng D,Chen M

    更新日期:2020-12-18 00:00:00

  • Chemical composition of various Ephedra species.

    abstract::The medicinal significance of Ephedra is based on the sympathomimetic properties of ephedrine (E) alkaloids. Pharmacological effects depend on the phytocomposition of individual Ephedra species. The aim of this study was to measure the total alkaloids content (TAC), total phenolics content (TPC), and total flavonoids ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2015.539

    authors: Ibragic S,Sofić E

    更新日期:2015-07-18 00:00:00

  • The effect of calcium channel blocker verapamil on gentamicin nephrotoxicity in rats.

    abstract::Aminoglycoside antibiotics are obligated nephrotoxins and inevitably cause renal failure during prolonged use. Experimental models of gentamicin-induced nephrotoxicity have shown histopathological, ultrastructural and functional alteration with blood urea nitrogen and serum creatinine increase leading to acute renal i...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.2977

    authors: Stojiljković N,Veljković S,Mihailović D,Stoiljković M,Radovanović D,Randelović P

    更新日期:2008-05-01 00:00:00

  • Significance of specificity of Tinetti B-POMA test and fall risk factor in third age of life.

    abstract::As for the third age, psychophysical abilities of humans gradually decrease, while the ability of adaptation to endogenous and exogenous burdens is going down. In 1987, "Harada" et al. (1) have found out that 9.5 million persons in USA have difficulties running daily activities, while 59% of them (which is 5.6 million...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2006.3210

    authors: Avdić D,Pecar D

    更新日期:2006-02-01 00:00:00

  • Epileptic psychoses - evaluation of clinical aspects.

    abstract::Epileptic psychoses as the most complex psychopathological phenomena represent unexplored states for prognosis. Clinical trials, conveyed in order to found risk factors still are not consistent in their conclusions. By this research results of all biological, clinical, psychological and social, as well as demographic ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2007.3069

    authors: Fiseković S,Burnazović L

    更新日期:2007-05-01 00:00:00

  • Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection.

    abstract::The diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in differentiating hepatocellular carcinoma (HCC) from other hepatic malignancies has not been investigated in Chinese patients with chronic liver disease from hepatitis B virus (HBV) infection. The aim of this study was to evaluate th...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2019.4576

    authors: Shao S,Liang Y,Kuang S,Chen J,Shan Q,Yang H,Zhang Y,Wang B,J Fowler K,Wang J,B Sirlin C

    更新日期:2020-08-03 00:00:00

  • Colorectal cancer: prognostic values.

    abstract::After lung cancer colorectal cancer (Cc) is ranked the second, as a cause of cancer-related death. The purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor border features. There ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2851

    authors: Manxhuka-Kerliu S,Telaku S,Ahmetaj H,Baruti A,Loxha S,Kerliu A

    更新日期:2009-02-01 00:00:00

  • Frequency and characteristics of side effects associated with antidepressant drugs.

    abstract::Depression is among the most common of chronic health problems. WHO report predicts that depression will be the leading cause of disability in the industrial world by the year 2020. To be successful, treatment for the patients suffering from depression must be continued until complete recovery, but most patients do no...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2002.3575

    authors: Kusturica J,Zulić I,Loga-Zec S,Mulabegović N,Loga S,Kapić E

    更新日期:2002-12-01 00:00:00

  • Injection pressure as a marker of intraneural injection in procedures of peripheral nerves blockade.

    abstract::The blockade of peripheral nerves carries a certain risk of unwanted complications, which can follow after unintentional intraneural injection of a local anesthetic. Up till today, the research of measuring injection pressure has been based on animal models, even though the histological structure of periphery nerve is...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2006.3107

    authors: Vucković I,Dilberović F,Kulenović A,Divanović KA,Voljevica A,Kapur E

    更新日期:2006-11-01 00:00:00

  • The importance of using peritoneal equlibration test for the peritoneal transport type characterization in continuous ambulatory peritoneal dialysis patients.

    abstract::The aim of this study was to analyze the importance of the peritoneal equilibration test (PET) in evaluation of the peritoneal membrane transport status in patients treated with continuous ambulatory peritoneal dialysis (CAPD). The study included 30 adult continuous ambulatory peritoneal dialysis (CAPD) patients, 16 m...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2645

    authors: Uncanin S,Rasić S,Rebić D,Dzemidzić J,Muslimović A,Begović B,Herenda V

    更新日期:2010-04-01 00:00:00

  • Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells.

    abstract::Nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in alcoholic liver disease. Chronic alcohol consumption enhances gut permeability and causes microbial translocation. The present study explored the activation of the NLRP3 inflammasome by Escherichia coli RNA in hepatic stellate cells (HSCs), and th...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2016.699

    authors: Wang H,Liu S,Wang Y,Chang B,Wang B

    更新日期:2016-01-14 00:00:00

  • p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women with abnormal cytology under 30 years old.

    abstract::Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunocytochemical staining can also be used for the detection of oncogenic changes in cervical cells. Our aim was to compare the perform...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.3560

    authors: Pirtea L,Secosan C,Margan M,Moleriu L,Balint O,Grigoras D,Sas I,Horhat F,Jianu A,Ilina R

    更新日期:2019-11-08 00:00:00

  • Posttraumatic seizures - prevention or not.

    abstract::Early posttraumatic epilepsies (EPTE) are epileptic attacks that appear in first seven days after brain injury, with incidence of 3-5%. Predictors for development of EPTE are: impressive skull fracture with rupture of dura, intracranial haemorrhage, neurogical deficit (brain contusion), and posttraumatic amnesia longe...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2005.3234

    authors: Gavranović M,Konjhodzić F,Zubcević S,Catibusić F,Uzicanin S

    更新日期:2005-11-01 00:00:00

  • Sonophoresis-mechanisms and application.

    abstract::There are numerous methods of administering drugs to the body, both passive and active. Active methods include the use of penetration enhancers and assisted drug delivery. One of them is sonophoresis (phonophoresis). This term is used to describe the effects of ultrasound on the movement of drugs through intact living...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2004.3410

    authors: Vranić E

    更新日期:2004-05-01 00:00:00

  • Fixed combination lisinopril plus hydro-chlorothiazide in the treatment of essential arterial hypertension: an opened, multi-centre, prospective clinical trial.

    abstract::The aim of this trial was to examine the efficacy and safety of antihypertensive fixed combination lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd) in the treatment of essential arterial hypertension. In our trial we included 297 patients, aged 54.65+/-9.6 years, with treated or untreated hypertension and...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.17305/bjbms.2007.3031

    authors: Gerc V,Begović B,Vehabović M,Voronkov LG,Vataman E,Musić L,Buksa M,Kusljugić Z,Ilyash MG,Ena LM,Tchelujko VI,Dyaduk AI,Bagrij AE,Andrievskaja SA,Vehabović A,Knezević B,Hima F

    更新日期:2007-11-01 00:00:00

  • Changes in serum homocysteine level follow two different trends in patients during early post myocardial infarction period.

    abstract::The evolution of homocysteine (Hcy) changes after acute myocardial infarction is still not elucidated. Serum Hcy concentration has been shown to increase between acute and convalescent period after myocardial infarction and stroke. Also a decrease in serum Hcy during acute phase was observed. It is still not clear whe...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2837

    authors: Valjevac A,Dzubur A,Nakas-Ićindić E,Hadzović-Dzuvo A,Zaćiragić A,Lepara O,Arslanagić A

    更新日期:2009-05-01 00:00:00

  • Therapeutic flexible bronchoscopy in child with cystic fibrosis.

    abstract::The report deals with the case of a 10-year-old girl with chronic cystic fibrosis. She has been repeatedly treated at the hospital. She has been hospitalized due to respiratory deterioration. Cystic fibrosis is a rare disease, inherited autosomaly recessively, but is very complex in terms of diagnostic and treatment (...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2005.3447

    authors: Selimović A

    更新日期:2005-05-01 00:00:00

  • Optimisation of forensic genetics procedures used in disputed paternity testing: adjustment of the PCR reaction volume.

    abstract::Standard molecular techniques, with only a slight modification, are very useful in obtaining and interpreting the final results in the field of forensic genetic. Data obtained through such analysis are highly reliable and can be used as a very powerful tool that produces valuable results. However, success and swiftnes...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2006.3179

    authors: Marjanović D,Bakal N,Kovacević L,Hodzić M,Haverić A,Haverić S,Ibrulj S,Durmić A

    更新日期:2006-05-01 00:00:00