Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity.

Abstract:

:The current study evaluates the impact of high saturated fat feeding in rat model of experimental nephrotoxicity induced by gentamicin. Sprague-Dawley rats weighing 200 g were randomized into four groups; the first one received the standard rodents chow for 8 weeks and was treated as control, the second group (HFD)received an experimental high fat diet rich in palm kernel oil (40% of Calories as fat) for the same period. The third group (HFDG) was given 80 mg/kg (body weight)/day gentamicin sulphate intraperitoneally during the last 24 days of the feeding period while the fourth group was given gentamicin as above along with the standard rodents chow. Renal function was assessed through measuring serum creatinine, creatinine clearance and absolute and fractional excretion of both sodium and potassium. At the end, rats underwent a surgical procedure for blood pressure measurement. Renal function study showed a stronger nephrotoxicity for HFDG group. Hypertension was observed in HFD group while the pressure declined after gentamicin co-administration. Overall, changing the feeding behavior toward using more SAFFAs for rats injected with gentamicin promotes the progression of renal failure.

journal_name

Bosn J Basic Med Sci

authors

Ibraheem ZO,Sattar MA,Abdullah NA,Rathore HA,Johns EJ

doi

10.17305/bjbms.2012.2527

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

26-32

issue

1

eissn

1512-8601

issn

1840-4812

journal_volume

12

pub_type

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