Introduction of the new analytical approaches to the doping control on the XIV Winter Olympic Games.

Abstract:

:In this paper we present introduction and development of some new analytical methods for identification of anabolic steroids, their metabolites and certain hormones, especially determination of exogenous testosterone by means of gas chromatography-mass spectrometry. Identification of central nervous stimulants and corticosteroides has been performed by high performance liquid chromatography. In desire to achieve better results, to increase strength and endurance, to sharpen reflexes and to reduce stress and anxiety athletes as well as other people use different pharmacological substances, hormones or even illicit drugs. Use of these substances without medical supervision can lead to adverse effects to one's health or even cause a death. At the same time, use of such substances means a kind of cheat that could not be accepted. This is why International Olympic Committee started at 1968 with official doping control that is permanently carried out and continuously increasing number of banned substances. Doping control demands for discover and development of new sensitive and specific methods for detection of banned substances and their metabolites in urine and blood.

journal_name

Bosn J Basic Med Sci

authors

Nikolin B,Lekić M,Sober M

doi

10.17305/bjbms.2003.3528

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

45-9

issue

3

eissn

1512-8601

issn

1840-4812

journal_volume

3

pub_type

杂志文章
  • Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells.

    abstract::Nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in alcoholic liver disease. Chronic alcohol consumption enhances gut permeability and causes microbial translocation. The present study explored the activation of the NLRP3 inflammasome by Escherichia coli RNA in hepatic stellate cells (HSCs), and th...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2016.699

    authors: Wang H,Liu S,Wang Y,Chang B,Wang B

    更新日期:2016-01-14 00:00:00

  • Spleen-preserving surgery in treatment of large mesothelial splenic cyst in children--a case report and review of the literature.

    abstract::The nonparasitic primary splenic cysts are very rare clinical entity. In the past, splenectomy was the treatment of choice but with the recognition of the spleen's important immunological function, spleen-preserving surgery is the preferred treatment modality. We hereby present a case of a large splenic mesothelial cy...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2013.2395

    authors: Zvizdić Z,Karavdić K

    更新日期:2013-05-01 00:00:00

  • MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC).

    abstract::MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.2376

    authors: Tong F,Ying Y,Pan H,Zhao W,Li H,Zhan X

    更新日期:2018-08-01 00:00:00

  • Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia.

    abstract::The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesic effects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of single preoperative dose of oral melatonin or vitamin C administration on...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.17305/bjbms.2019.4379

    authors: Laflı Tunay D,Türkeün Ilgınel M,Ünlügenç H,Tunay M,Karacaer F,Biricik E

    更新日期:2020-02-05 00:00:00

  • Changes in serum homocysteine level follow two different trends in patients during early post myocardial infarction period.

    abstract::The evolution of homocysteine (Hcy) changes after acute myocardial infarction is still not elucidated. Serum Hcy concentration has been shown to increase between acute and convalescent period after myocardial infarction and stroke. Also a decrease in serum Hcy during acute phase was observed. It is still not clear whe...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2837

    authors: Valjevac A,Dzubur A,Nakas-Ićindić E,Hadzović-Dzuvo A,Zaćiragić A,Lepara O,Arslanagić A

    更新日期:2009-05-01 00:00:00

  • Berberine alleviates oxidative stress in rats with osteoporosis through receptor activator of NF-kB/receptor activator of NF-kB ligand/osteoprotegerin (RANK/RANKL/OPG) pathway.

    abstract::Previous studies suggested that oxidative stress is related to the onset and development of osteoporosis. Moreover, it was demonstrated that berberine has a protective effect against oxidative stress-induced injuries. In this study, we aimed to investigate the effect and mechanism of action of berberine on rats with i...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.2596

    authors: He XF,Zhang L,Zhang CH,Zhao CR,Li H,Zhang LF,Tian GF,Guo MF,Dai Z,Sui FG

    更新日期:2017-11-20 00:00:00

  • The effect of a probiotic strain (Lactobacillus acidophilus) on the plaque formation of oral Streptococci.

    abstract::The objective of this study was to investigate the ability of biofilm formation among mutans and non mutans oral streptococci and to determine the effect of Lactobacillus acidophilus DSM 20079 as a probiotic strain on the adhesion of selected streptococcal strains on the surfaces. The sample comprised 40 isolates of o...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2011.2621

    authors: Tahmourespour A,Kermanshahi RK

    更新日期:2011-02-01 00:00:00

  • Femoro-popliteal bypass above knee with saphenous vein vs synthetic graft.

    abstract::There is still debate whether sintethic graft (polytetrafluoroethylene or Dacron) is equivalent to vein as bypass graft material for the above-knee femoropopliteal bypass. Therefore, we performed prospective randomized trial to compare vein with polytetrafluoroethylene/dacron for femoropopliteal bypasses with the dist...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.17305/bjbms.2008.2899

    authors: Solaković E,Totić D,Solaković S

    更新日期:2008-11-01 00:00:00

  • When less is more in the intensive care unit; lessons learned.

    abstract::In parallel to technological advances in late twentieth century, medical diagnostics and therapeutic options greatly improved. A surge of evidence-based research in intensive care medicine provided additional opportunities and the "best" medical practice has been changing rapidly. However, the primary focus of Hippocr...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2763

    authors: Festic E,Gajic O

    更新日期:2009-10-01 00:00:00

  • Protective effect of neonatal BCG vaccines against tuberculous meningitis.

    abstract::Neonatal BCG vaccination reduces the risk of tuberculosis and provides protection higher than 80% against the development of meningeal and miliary tuberculosis in newborns. Tuberculosis meningitis remains a major problem and also an important cause of death in some countries. In countries with high and moderate incide...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 临床试验,杂志文章

    doi:10.17305/bjbms.2004.3460

    authors: Puvacić S,Dizdarević J,Santić Z,Mulaomerović M

    更新日期:2004-02-01 00:00:00

  • Treatment options for thoracolumbar spine fractures.

    abstract::A decision for operative versus nonoperative management of thoracolumbar fractures should NEVER be based solely on one factor. Only after a thorough physical, neurological, and spinal examination, and an assessment of a patient's prior activity, social and educational background and patient's expectations, one should ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2005.3279

    authors: Karaiković EE,Pacheco HO

    更新日期:2005-05-01 00:00:00

  • The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes.

    abstract::Tocotrienol rich fraction (TRF) is an extract of palm oil, which consists of 25% alpha tocopherol (α-TCP) and 75% tocotrienols. TRF has been shown to possess potent antioxidant, anti-inflammatory, anticancer, neuroprotection, and cholesterol lowering activities. Glutamate is the main excitatory amino acid neurotransmi...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2014.4.91

    authors: Selvaraju TR,Khaza'ai H,Vidyadaran S,Abd Mutalib MS,Vasudevan R

    更新日期:2014-11-16 00:00:00

  • The Ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans.

    abstract::Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Because morbidity after repeated surgery may be significant, an optimized prediction of re...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.5088

    authors: Adem D,Yazici S,Ozsen M,Cetintas SK,Yalcinkaya U,Şahin AB,Tanrıverdi O,Orhan SO,Ocak B,Cubukcu E,Kahveci R,Evrensel T

    更新日期:2020-10-20 00:00:00

  • The influence of renal alograft function on cardiovscular status and left ventricular remodelling.

    abstract::The synergy and shared co-morbidity, certainly interplay between kidney and cardiovascular disease, where advanced renal failure influences on progression of cardiac disease in bi-direction relationship. Cardiovascular diseases are cause of death in almost 50% of uremic patients. Correction of uremia after successful ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2827

    authors: Dzemidzić J,Rasić S,Saracević A

    更新日期:2009-05-01 00:00:00

  • Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.

    abstract::Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Mature epithelial tissues originate from different embryonic germ layers. The objective of this research was to explore the presence and localization of TFF3 peptide in mouse embryonic epithelia and...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.1838

    authors: Bijelić N,Belovari T,Tolušić Levak M,Baus Lončar M

    更新日期:2017-08-20 00:00:00

  • Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection.

    abstract::The diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in differentiating hepatocellular carcinoma (HCC) from other hepatic malignancies has not been investigated in Chinese patients with chronic liver disease from hepatitis B virus (HBV) infection. The aim of this study was to evaluate th...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2019.4576

    authors: Shao S,Liang Y,Kuang S,Chen J,Shan Q,Yang H,Zhang Y,Wang B,J Fowler K,Wang J,B Sirlin C

    更新日期:2020-08-03 00:00:00

  • Experimental model of the burn wound topical treatment.

    abstract:BACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burn inducement and effects of the ointment containing natural plants on the process of burn heal...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2003.3495

    authors: Cabaravdić A,Zulić I,Mornjaković Z,Mijanović M,Becić F

    更新日期:2003-11-01 00:00:00

  • The effect of metformin treatment on endoplasmic reticulum (ER) stress induced by status epilepticus (SE) via the PERK-eIF2α-CHOP pathway.

    abstract::Status epilepticus (SE) is defined as continuous seizure activity lasting more than 5 minutes. It results in neuronal cell death, mediated by endoplasmic reticulum (ER) stress response. Previously, metformin demonstrated neuroprotective effects in primary cortical neurons. In this study, we analyzed the effect of metf...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.2044

    authors: Chen J,Zheng G,Guo H,Shi ZN,Jiang J,Wang XY,Yang X,Liu XY

    更新日期:2018-02-20 00:00:00

  • A three-dimensional computed tomography study to determine the ideal method for fluoroscopically-guided bone marrow aspiration from the iliac crest.

    abstract::Bone marrow aspiration (BMA) through the iliac crest is potentially unsafe due to the vicinity of neurovascular structures in the greater sciatic notch. Our objective was to investigate the safety of a recently described BMA technique, specifically a trajectory from the posterior superior iliac spine (PSIS) to the ant...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4744

    authors: D'Souza RS,Li L,Leng S,Hunt C,Law L,Muir C,Eldrige J,Bydon M,Chi M,Shapiro S,Mauck WD,Qu W

    更新日期:2020-05-11 00:00:00

  • Analysis of long non-coding RNA (lncRNA) expression in hepatitis B patients.

    abstract::Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression of lncRNAs and disruption of the regulatory processes are recognized as critical steps in c...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.2800

    authors: Yılmaz Susluer S,Kayabasi C,Ozmen Yelken B,Asik A,Celik D,Balci Okcanoglu T,Serin Senger S,Biray Avci C,Kose S,Gunduz C

    更新日期:2018-05-20 00:00:00

  • Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer.

    abstract::Non-small-cell lung cancer (NSCLC) with KRAS (Kirsten RAt Sarcoma 2 viral oncogene homolog) mutation has become a clinical challenge in cancer treatment as KRAS-mutant tumors are often resistant to conventional anti-tumor therapies. Activated CDC42-associated kinase 1 (ACK1), an activator of protein kinase B (AKT), is...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4746

    authors: Yu X,Liu J,Qiu H,Hao H,Zhu J,Peng S

    更新日期:2020-06-01 00:00:00

  • Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia.

    abstract::The glutathione S-transferase (GST) genes encode enzymes that mediate the detoxification of xenobiotics by catalyzing the conjugation of glutathione (GSH) to xenobiotic substrates. The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) am...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2019.4176

    authors: Muddathir ARM,Abdallah EI,Khabour OF,Abdelgader RE,Elgari MM

    更新日期:2019-04-15 00:00:00

  • Heart murmur and anaemia in the pediatric population.

    abstract::Innocent heart murmurs are hearth murmurs that occur in patients with a normal heart structure. They do not represent a disease of the heart and vascular system, and should not be treated as such. Iron-deficiency anaemia often causes, along with other symptoms, systolic heart murmurs and tachycardia. It appears in chi...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2005.3269

    authors: Mesihović-Dinarević S,Ibrahimović J,Hasanbegović E,Ićindić-Nakas E,Smajić A

    更新日期:2005-08-01 00:00:00

  • Aerobic capacity as an indicator in different kinds of sports.

    abstract::Physical capacity of athletes is an important element of success in sports achievements. Aerobic capacity has been accepted as its major component. Maximal oxygen uptake (VO2max) has been regarded by majority of authors as the best indicator of aerobic capacity of an organism, and at the same time, the best indicator ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2734

    authors: Rankovic G,Mutavdzic V,Toskic D,Preljevic A,Kocic M,Nedin Rankovic G,Damjanovic N

    更新日期:2010-02-01 00:00:00

  • Cardiovascular screening in young athletes in Sarajevo Canton.

    abstract::Potential risk of sudden death during sports participation makes screening of competitive athletes of vital importance. Congenital cardiac anomalies and non-atherosclerotic, acquired myocardial conditions are primary causes underlying exercise-induced cardiac death in young patients. Since cardiovascular conditions ar...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2692

    authors: Mesihović-Dinarević S,Kulić M,Kreso A

    更新日期:2010-08-01 00:00:00

  • Comprehensive analysis of patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody.

    abstract::Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.2255

    authors: Liu J,Xu L,Chen ZL,Li M,Yi H,Peng FH

    更新日期:2018-02-20 00:00:00

  • Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.

    abstract::Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu 1 on alcohol and tobacco consumption in a Spanish population. 763 unre...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2015.243

    authors: Francès F,Portolés O,Castelló A,Costa JA,Verdú F

    更新日期:2015-04-25 00:00:00

  • Methylenetetrahydrofolate Reductase gene polymorphism in patients receiving hemodialysis.

    abstract::Methylenetetrahydrofolate Reductase (MTHFR) is key enzyme in metabolism of homocysteine. Homozygotes for mutation (TT genotype) have hyperhomocysteinemia, risk factor for atherosclerosis development. The aim of the study was to find out distribution of genotype frequencies of C677T MTHFR among patients on maintenance ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2656

    authors: Kiseljaković E,Resić H,Kapur L,Hasić S,Jadrić R

    更新日期:2010-04-01 00:00:00

  • In which regions is breast-feeding safer from the impact of toxic elements from the environment?

    abstract::Owing to its unique nutritional and immunological characteristics, breast milk is the most important food source for infants. But, children are at greater risk for exposure to environmental toxicants from breast milk. The aim of this study was to evaluate the influence of environmental pollution on essential and toxic...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2011.2556

    authors: Cinar N,Ozdemir S,Yucel O,Ucar F

    更新日期:2011-11-01 00:00:00

  • Helicobacter pylori as a promoter of accelerated regeneration, pathological differentiation and transformation of normal gastric mucosa into cancerous type.

    abstract::The aim of the study was to ascertain presence of Helicobacter pylori in gastric carcinoma as a responsible promoter of inflammatory-regenerative changes, which lead to pathological differentiation and transformation of normal epithelial cells into intestinal type and, in progression, cause epithelial dysplasia that d...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2006.3146

    authors: Vukobrat-Bijedić Z,Radović S,Husić-Selimović A,Gornjaković S

    更新日期:2006-08-01 00:00:00