The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes.

Abstract:

:Tocotrienol rich fraction (TRF) is an extract of palm oil, which consists of 25% alpha tocopherol (α-TCP) and 75% tocotrienols. TRF has been shown to possess potent antioxidant, anti-inflammatory, anticancer, neuroprotection, and cholesterol lowering activities. Glutamate is the main excitatory amino acid neurotransmitter in the central nervous system of mammalian, which can be excitotoxic, and it has been suggested to play a key role in neurodegenerative disorders like Parkinson's and Alzheimer's diseases. In this present study, the effects of vitamin E (TRF and α-TCP) in protecting astrocytes against glutamate injury were elucidated. Astrocytes induced with 180 mM of glutamate lead to significant cell death. However, glutamate mediated cytotoxicity was diminished via pre and post supplementation of TRF and α-TCP. Hence, vitamin E acted as a potent antioxidant agent in recovering mitochondrial injury due to elevated oxidative stress, and enhanced better survivability upon glutamate toxicity.

journal_name

Bosn J Basic Med Sci

authors

Selvaraju TR,Khaza'ai H,Vidyadaran S,Abd Mutalib MS,Vasudevan R

doi

10.17305/bjbms.2014.4.91

subject

Has Abstract

pub_date

2014-11-16 00:00:00

pages

195-204

issue

4

eissn

1512-8601

issn

1840-4812

journal_volume

14

pub_type

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