Abstract：
:One of the most frequent hereditary causes of thrombophilia is, without a doubt, resistance to Activated Protein C (APC-resistance), which is a consequence of point mutation in gene coding for coagulation Factor V (Factor V Leiden) in 90-95% of cases. The aim of this paper was to determine prevalence of APC-resistance in a group of healthy blood donors. The size of the group is quite representative of Kosovo Albanians. A total of 944 blood donors were examined (537 males and 407 females), for whom APC-resistance was determined by functional methods of coagulation using the kit ACTICLOT(R) Protein C Resistance. Method is based on the test of APTT determined twice: first in the presence and second in the absence of activated Protein C (APC). The ratio of these two values constitutes is called Activated Protein C- Sensitivity Ratio (APC-SR). From 944 examined donors, pathologic values of APC-SR (1,3-1,9) were found in 32 persons (3,4% of the total number). The distribution among sexes was 3,35% (18/537) in male and 3,43% (14/407) in female subjects. The mean values of APC-SR (1,64 in male and 1,71 in female subjects) were not significantly different (P = 0,22). Based on these results, we conclude that the prevalence of APC resistance in Albanian population of Kosovo is within the lower limit of prevalence in general population in different countries of European countries, which, according to some authors ranges is from 3 to 7%.
journal_name
Bosn J Basic Med Scijournal_title
Bosnian journal of basic medical sciencesauthors
Mekaj Y,Zhubi B,Hoxha H,Belegu R,Mekaj A,Miftari E,Belegu Mdoi
10.17305/bjbms.2009.2789subject
Has Abstractpub_date
2009-11-01 00:00:00pages
329-34issue
4eissn
1512-8601issn
1840-4812journal_volume
9pub_type
杂志文章abstract：:The medicinal significance of Ephedra is based on the sympathomimetic properties of ephedrine (E) alkaloids. Pharmacological effects depend on the phytocomposition of individual Ephedra species. The aim of this study was to measure the total alkaloids content (TAC), total phenolics content (TPC), and total flavonoids ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
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abstract：:Spermatogenesis is a tightly controlled, multi-step process in which mature spermatozoa are produced. Disruption of regulatory mechanisms in spermatogenesis can lead to male infertility, various diseases of male reproductive system, or even cancer. The spermatogenic impairment in infertile men can be associated with d...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,评审
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journal_title：Bosnian journal of basic medical sciences
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2008.2964
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更新日期：2020-04-27 00:00:00
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更新日期：2020-05-11 00:00:00
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journal_title：Bosnian journal of basic medical sciences
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更新日期：2013-08-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
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更新日期：2015-08-26 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2007.3021
更新日期：2007-11-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2013.2419
更新日期：2013-02-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2009.2763
更新日期：2009-10-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2009.2827
更新日期：2009-05-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2008.2994
更新日期：2008-02-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2008.2919
更新日期：2008-08-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2009.2861
更新日期：2009-02-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2009.2837
更新日期：2009-05-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2004.3410
更新日期：2004-05-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
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更新日期：2020-06-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,meta分析
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更新日期：2020-02-05 00:00:00
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journal_title：Bosnian journal of basic medical sciences
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pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,评审
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更新日期：2004-10-01 00:00:00
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journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
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更新日期：2017-08-20 00:00:00
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journal_title：Bosnian journal of basic medical sciences
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更新日期：2011-11-01 00:00:00
abstract：:The aim of the study was to ascertain presence of Helicobacter pylori in gastric carcinoma as a responsible promoter of inflammatory-regenerative changes, which lead to pathological differentiation and transformation of normal epithelial cells into intestinal type and, in progression, cause epithelial dysplasia that d...
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doi：10.17305/bjbms.2006.3146
更新日期：2006-08-01 00:00:00
