Abstract：
:The aim of study was to evaluate endocrine changes in PCOS women during metformin treatment. One hundred women with PCOS, aged 20-40 years were included. A complete hormonal and metabolic pattern was recorded for each subject every 6 months. Metformin treatment after 6 and 12 months significantly reduced weight, BMI, waist circumference, insulin and HOMA-IR (p=0.000) with high differences of variances within repeated measurements. There was significant reduction of PRL, testosterone and estradiol (p=0.000) with small differences within repeated measurements. Metformin did not have effect on TSH. However, results showed important reduction of CRP, LH, LH/FSH, androstendione, DHEA-S and progesterone (p=0.000) with moderate differences within measures. Metformin restored menstrual cyclicity in most participants. At baseline in study group was 69% women with oligomenorrhoea, amenorrhoea or polymenorrhoea. After 12 months of treatment, only 20% PCOS women had irregular menstrual cycle (p=0.000). Hirsutism was also reduced. Intriguingly, during first 6 months of treatment in PCOS women 9 pregnancies occurred (p=0.000), while during last 6 months treatment were 2 pregnancies (p=0.317), in total 11(13%). Multiple regression model revealed that the presence of anovulation in PCOS women was strongly associated with BMI, waist, FSH and age. Insulin resistance was significantly predicted by BMI, cholesterol, progesterone and presence of hirsutism. The metformin therapy significantly improved insulin resistance, imbalance of endocrine hormones, hirsutism and menstrual cyclicity in women with PCOS. The most important predictors for duration of metformin treatment in PCOS women were testosterone, progesterone, FSH, CRP and presence of anovulation.
journal_name
Bosn J Basic Med Scijournal_title
Bosnian journal of basic medical sciencesauthors
Velija-Ašimi Zdoi
10.17305/bjbms.2013.2359subject
Has Abstractpub_date
2013-08-01 00:00:00pages
180-5issue
3eissn
1512-8601issn
1840-4812journal_volume
13pub_type
杂志文章abstract：:Most of today available non-invasive procedures cannot clearly determinate between benign and malignant solitary pulmonary nodules (SPN). The purpose of the study was to assess the possibility of using 99mTc labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) to differentiate benign from malignant SPN. Sixty pati...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2011.2570
更新日期：2011-08-01 00:00:00
abstract：:The glutathione S-transferase (GST) genes encode enzymes that mediate the detoxification of xenobiotics by catalyzing the conjugation of glutathione (GSH) to xenobiotic substrates. The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) am...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2019.4176
更新日期：2019-04-15 00:00:00
abstract：BACKGROUND AND PURPOSE:Carcinoembryonic antigen (CEA) is used as a tumour marker in breast cancer (BC). In order to assess diagnostic value of CEA in BC we examined its serum levels and frequencies of its increase in breast cancer patients (BCP), and compared them to those in controls. We also determined CEA in patient...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2003.3552
更新日期：2003-05-01 00:00:00
abstract：:Kidney transplantation (Ktx) is generally performed during end stage renal disease due to a loss of the kidneys' ability to filter wastes from the circulatory system. Acute graft-versus-host disease (GVHD) after Ktx is a life-threatening complication that progresses to organ failure, systemic complications, and death....
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2011.2594
更新日期：2011-05-01 00:00:00
abstract：:The aim of this trial was to examine the efficacy and safety of antihypertensive fixed combination lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd) in the treatment of essential arterial hypertension. In our trial we included 297 patients, aged 54.65+/-9.6 years, with treated or untreated hypertension and...
journal_title：Bosnian journal of basic medical sciences
pub_type： 临床试验,杂志文章,多中心研究
doi：10.17305/bjbms.2007.3031
更新日期：2007-11-01 00:00:00
abstract：:Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt signaling pathway during embryonic development. The role of DVL proteins in the placental tissue remains mostly unknown. In the current study, we explored the role of Dishevelled proteins in...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2020.5422
更新日期：2020-12-26 00:00:00
abstract：:There is still debate whether sintethic graft (polytetrafluoroethylene or Dacron) is equivalent to vein as bypass graft material for the above-knee femoropopliteal bypass. Therefore, we performed prospective randomized trial to compare vein with polytetrafluoroethylene/dacron for femoropopliteal bypasses with the dist...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,随机对照试验
doi：10.17305/bjbms.2008.2899
更新日期：2008-11-01 00:00:00
abstract：:A decision for operative versus nonoperative management of thoracolumbar fractures should NEVER be based solely on one factor. Only after a thorough physical, neurological, and spinal examination, and an assessment of a patient's prior activity, social and educational background and patient's expectations, one should ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,评审
doi：10.17305/bjbms.2005.3279
更新日期：2005-05-01 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) are involved in a range of biological processes, such as cellular differentiation, migration, apoptosis, invasion, proliferation, and transcriptional regulation. The aberrant expression of lncRNAs plays a significant role in several cancer types. Aurora kinases are increasingly expressed...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2019.4155
更新日期：2020-02-05 00:00:00
abstract：:Staphylococcus aureus has long been recognized as one of the leading cause of hospital infections all over the world. Increased frequency of methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized patients and possibility of vancomycin resistance requires rapid and reliable characterization of isolates and ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2008.2930
更新日期：2008-08-01 00:00:00
abstract：:Diabetes mellitus can be looked upon as an array of diseases, all of which exhibit common symptoms. While pathogenesis of IDDM (insulin dependant diabetes mellitus) is well understood, the same is not true for diabetes mellitus type II. In the latter case, relative contribution of the two factors (insulin resistance o...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2006.3135
更新日期：2006-08-01 00:00:00
abstract：:The synergy and shared co-morbidity, certainly interplay between kidney and cardiovascular disease, where advanced renal failure influences on progression of cardiac disease in bi-direction relationship. Cardiovascular diseases are cause of death in almost 50% of uremic patients. Correction of uremia after successful ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2009.2827
更新日期：2009-05-01 00:00:00
abstract：:Having in mind the fact that cerebrovascular disease (CVB) takes today in medicine, in spite of diagnostic and therapeutic modernisation, the third place of mortality causes in the world (behind cordial and malignant diseases, but in front of depressions), and the second place of invalidity cause (right after trauma) ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2002.3585
更新日期：2002-12-01 00:00:00
abstract：:Status epilepticus (SE) is defined as continuous seizure activity lasting more than 5 minutes. It results in neuronal cell death, mediated by endoplasmic reticulum (ER) stress response. Previously, metformin demonstrated neuroprotective effects in primary cortical neurons. In this study, we analyzed the effect of metf...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2017.2044
更新日期：2018-02-20 00:00:00
abstract：:Early posttraumatic epilepsies (EPTE) are epileptic attacks that appear in first seven days after brain injury, with incidence of 3-5%. Predictors for development of EPTE are: impressive skull fracture with rupture of dura, intracranial haemorrhage, neurogical deficit (brain contusion), and posttraumatic amnesia longe...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2005.3234
更新日期：2005-11-01 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression of lncRNAs and disruption of the regulatory processes are recognized as critical steps in c...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2018.2800
更新日期：2018-05-20 00:00:00
abstract：:The nonparasitic primary splenic cysts are very rare clinical entity. In the past, splenectomy was the treatment of choice but with the recognition of the spleen's important immunological function, spleen-preserving surgery is the preferred treatment modality. We hereby present a case of a large splenic mesothelial cy...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,评审
doi：10.17305/bjbms.2013.2395
更新日期：2013-05-01 00:00:00
abstract：:Potential risk of sudden death during sports participation makes screening of competitive athletes of vital importance. Congenital cardiac anomalies and non-atherosclerotic, acquired myocardial conditions are primary causes underlying exercise-induced cardiac death in young patients. Since cardiovascular conditions ar...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2010.2692
更新日期：2010-08-01 00:00:00
abstract：:MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2018.2376
更新日期：2018-08-01 00:00:00
abstract：:The evolution of homocysteine (Hcy) changes after acute myocardial infarction is still not elucidated. Serum Hcy concentration has been shown to increase between acute and convalescent period after myocardial infarction and stroke. Also a decrease in serum Hcy during acute phase was observed. It is still not clear whe...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2009.2837
更新日期：2009-05-01 00:00:00
abstract：:Non-coding RNAs play a critical role in gene regulation in cancer cells. Reduced expression of microRNA-192 (miR-192) has been detected in many cancers. In this study, we investigated the role of miR-192 in cell proliferation and cell cycle control in NALM-6 cell line, a model of acute lymphoblastic leukemia (ALL). Ce...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2017.1921
更新日期：2017-08-20 00:00:00
abstract：:As for the third age, psychophysical abilities of humans gradually decrease, while the ability of adaptation to endogenous and exogenous burdens is going down. In 1987, "Harada" et al. (1) have found out that 9.5 million persons in USA have difficulties running daily activities, while 59% of them (which is 5.6 million...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2006.3210
更新日期：2006-02-01 00:00:00
abstract：:Methylenetetrahydrofolate Reductase (MTHFR) is key enzyme in metabolism of homocysteine. Homozygotes for mutation (TT genotype) have hyperhomocysteinemia, risk factor for atherosclerosis development. The aim of the study was to find out distribution of genotype frequencies of C677T MTHFR among patients on maintenance ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2010.2656
更新日期：2010-04-01 00:00:00
abstract：:Lung cancer is responsible for 40% mortalities from malignant diseases in man and exhibits an extremely infiltrating way of growing. It does not respect the lobes' or the organs' borders and spreads by blood system, lymph system and per continuitatem. According to its biological characteristics and response to treatme...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2007.3052
更新日期：2007-08-01 00:00:00
abstract：:The aim of the study was to verify the presence of mutated tumor suppresser gene p53 in intestinal mucosa with histologically confirmed premalignant lesions and gastric carcinoma, and assess its prognostic value. The paper presents prospective study that included 50 patients with gastric adeno-carcinoma of intestinal ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2007.3080
更新日期：2007-02-01 00:00:00
abstract：:Epileptic psychoses as the most complex psychopathological phenomena represent unexplored states for prognosis. Clinical trials, conveyed in order to found risk factors still are not consistent in their conclusions. By this research results of all biological, clinical, psychological and social, as well as demographic ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2007.3069
更新日期：2007-05-01 00:00:00
abstract：:The medicinal significance of Ephedra is based on the sympathomimetic properties of ephedrine (E) alkaloids. Pharmacological effects depend on the phytocomposition of individual Ephedra species. The aim of this study was to measure the total alkaloids content (TAC), total phenolics content (TPC), and total flavonoids ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2015.539
更新日期：2015-07-18 00:00:00
abstract：:Growth hormone is essential for body growth but it also modulates metabolic pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary functions. Numerous beneficial effects of growth hormone have led to its expanded therapeutic use in both children and adults. There are several officially approve...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章,评审
doi：10.17305/bjbms.2004.3365
更新日期：2004-10-01 00:00:00
abstract：:The objective of our study was to evaluate bladder outlet obstruction number (BOON) in order to predict infravesical obstruction in patients with benign prostatic enlargement (BPE). Two hundred patients with proven BPE from daily urological practice at the Urology Department of the Sarajevo University Clinical Centre ...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2012.2459
更新日期：2012-08-01 00:00:00
abstract：:In this paper we present introduction and development of some new analytical methods for identification of anabolic steroids, their metabolites and certain hormones, especially determination of exogenous testosterone by means of gas chromatography-mass spectrometry. Identification of central nervous stimulants and cor...
journal_title：Bosnian journal of basic medical sciences
pub_type： 杂志文章
doi：10.17305/bjbms.2003.3528
更新日期：2003-07-01 00:00:00
