Abstract:
INTRODUCTION:This clinical study was conducted to measure the endotoxin levels in infected root canals (RCs) and exudates related to acute apical abscesses (AAAs). In addition, the effectiveness of RC procedures in reducing the endotoxin levels in RCs was monitored. METHODS:Paired samples of infected RCs and exudates from AAAs were collected from 10 subjects by using paper points. RCs samples were collected before (RCS1) and after chemomechanical preparation (CMP) (RCS2), after 17% EDTA (RCS3), and after 30 days of intracanal medication (Ca[OH]2 + chlorhexidine) (RCS4). A turbidimetric kinetic limulus amebocyte lysate assay was used for the measurement of endotoxins. RESULTS:Endotoxins were detected in 100% of the baseline samples of AAAs and RCs (RCS1) with median values of 175 EU/mL and 41.5 EU/mL, respectively (P < .05). After CMP (RCS2), endotoxins were reduced to a median value of 0.54 EU/mL (P < .05). Subsequent irrigation with EDTA (RCS3) failed to present a significant effectiveness in reducing the endotoxin levels (median= 0.37 EU/mL) (P = .07). However, intracanal medication for 30 days (RCS4) reduced endotoxins to median values of 0.03 EU/mL (P < .01). CONCLUSIONS:The present study revealed a strong association between the high levels of endotoxins found in AAAs and RCs collected from the same tooth. Moreover, the effectiveness of CMP in reducing the endotoxin levels from RCs in acute endodontic infection was improved by the use of RC medication.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Sousa EL,Martinho FC,Nascimento GG,Leite FR,Gomes BPdoi
10.1016/j.joen.2013.10.008subject
Has Abstractpub_date
2014-02-01 00:00:00pages
177-81issue
2eissn
0099-2399issn
1878-3554pii
S0099-2399(13)00904-7journal_volume
40pub_type
杂志文章abstract::The purpose of this in vitro study was to investigate the canal configuration types, and the prevalence and location of anatomical variations in the mesiobuccal (MB) and mesial roots of permanent maxillary and mandibular first molars after instrumentation. The number and the type of canals were determined before instr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000145425.73364.91
更新日期:2005-05-01 00:00:00
abstract:INTRODUCTION:This retrospective study assessed the effects of microsurgical treatment of post-treatment endodontic disease using SuperEBA (Bosworth, Skokie, IL) as the root-end filling material and evaluated the potential prognostic factors in relation to outcome. METHODS:Data were collected from patients diagnosed wi...
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更新日期:2014-03-01 00:00:00
abstract::A nested polymerase chain reaction (PCR)-based method was used to directly survey samples taken from primary endodontic infections for the occurrence of Pseudoramibacter alactolyticus. Identification by nested PCR was performed in root-canal samples from teeth associated with asymptomatic periradicular lesions or acut...
journal_title:Journal of endodontics
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更新日期:2003-11-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2011.01.005
更新日期:2011-04-01 00:00:00
abstract::Atypical odontalgia is characterized by prolonged periods of throbbing or burning pain in the teeth or alveolar process, which occurs in the absence of any identifiable odontogenic etiology. The pain may be bilateral and change in location. This article presents two cases of atypical odontalgia that were misdiagnosed ...
journal_title:Journal of endodontics
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更新日期:1997-05-01 00:00:00
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journal_title:Journal of endodontics
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更新日期:2016-04-01 00:00:00
abstract::A long-standing lesion associated with an undetected perforation of the furca in a mandibular molar was successfully managed using a multidisciplinary treatment approach. The sequence of therapeutic procedures involved conventional endodontic retreatment, an initial orthograde sealing of the perforation, guided tissue...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80989-1
更新日期:1995-11-01 00:00:00
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journal_title:Journal of endodontics
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更新日期:1999-02-01 00:00:00
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journal_title:Journal of endodontics
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更新日期:2015-09-01 00:00:00
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doi:10.1016/j.joen.2016.10.034
更新日期:2017-03-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2005.10.035
更新日期:2006-03-01 00:00:00
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journal_title:Journal of endodontics
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.01.010
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Candida in endodontic infections has been investigated in a large number of studies, but its role as an endodontic pathogen is still debatable. The aim of this study was to systematically review the literature on the prevalence of Candida species in root canal infections. METHODS:Extensive literature rese...
journal_title:Journal of endodontics
pub_type: 杂志文章,meta分析
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更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to determine the relationship between histologic and radiologic signs of inflammation in human root-filled teeth. In addition, other factors with possible importance for apical inflammation were assessed. Fifty-three block sections of root-filled teeth were gathered from human cadavers. The b...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200402000-00003
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:Previous studies have suggested that masticatory forces are associated with cracked teeth, but it is not clear which specific poor oral masticatory habits may be more likely to cause cracks. The aim of this study was to quantitatively assess risk factors for cracked teeth among poor oral masticatory habits...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.01.007
更新日期:2017-06-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.12.022
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:Failure in endodontic treatment is often caused by the persistence of microorganisms in the root canal after therapy. When treatment fails, an immune response develops that is characterized by an extensive network of immunologic mechanisms that lead to the production of cytokines and chemokines. METHODS:T...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.08.007
更新日期:2011-12-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.12.010
更新日期:2020-03-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(97)80347-0
更新日期:1997-12-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-11-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80091-9
更新日期:1994-07-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(99)80347-1
更新日期:1999-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200202000-00014
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:The lysyl oxidase (LOX) family is an emerging family of amine oxidases responsible for the formation of collagen fibrils in the extracellular matrix. To date, 5 LOX family genes have been identified in humans, encoding LOX and LOX-like proteins (LOXL, LOXL2, LOXL3, and LOXL4). The goal of this study was to...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.03.014
更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81411-1
更新日期:1992-04-01 00:00:00