Vitamin D receptor and its protective role in diabetic nephropathy.

Abstract:

OBJECTIVE:To review the advances of studies on vitamin D receptor and its role in the pathogenesis of diabetic nephropathy. DATA SOURCES:A comprehensive search of the PubMed literatures without restriction on the publication date was carried out using keywords such as vitamin D receptor and diabetic nephropathy. STUDY SELECTION:Articles related to vitamin D receptor and diabetic nephropathy were selected and carefully analyzed. RESULTS:The ligands as well as construction and tissue distribution of vitamin D receptor were summarized. Pathogenesis of diabetic nephropathy was analyzed. The mechanisms underlying the renoprotective role of vitamin D receptor including inhibition of renin-angiotensin system, anti-inflammation, anti-fibrosis and the reduction of proteinuria were reviewed. Mounting evidences from animal and clinical studies have suggested that vitamin D therapy has beneficial effects on the renal systems and the underlying renoprotective mechanisms of the vitamin D receptor-mediated signaling pathways is a hot research topic. CONCLUSION:Our study suggests that vitamin D receptor has a great potential for preventing the progression of diabetic nephropathy via multiple mechanisms.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Guan X,Yang H,Zhang W,Wang H,Liao L

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

365-9

issue

2

eissn

0366-6999

issn

2542-5641

journal_volume

127

pub_type

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