The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.


:The International Mouse Phenotyping Consortium (IMPC) web portal ( provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.


Nucleic Acids Res


Nucleic acids research


Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos




Has Abstract


2014-01-01 00:00:00




Database issue










  • Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021.

    abstract::The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a suite of database resources to support worldwide research activities in both academia and industry. With the explosive growth of multi-omics data, CNCB-NGDC is continually expanding, updating and enriching...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: CNCB-NGDC Members and Partners.

    更新日期:2021-01-08 00:00:00

  • A tRNA gene of Xenopus laevis contains at least two sites promoting transcription.

    abstract::A small cloned DNA segment previously shown to contain all genetic information for the expression of the tRNA1met gene of Xenopus laevis was cleaved into an anterior and posterior portion by Hae III restriction. Both restriction fragments were cloned in pCR1 using EcoRI linkers. Starting from these tDNA subclones, a s...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kressmann A,Hofstetter H,Di Capua E,Grosschedl R,Birnstiel ML

    更新日期:1979-12-11 00:00:00

  • SitEx: a computer system for analysis of projections of protein functional sites on eukaryotic genes.

    abstract::Search of interrelationships between the structural-functional protein organization and exon structure of encoding gene provides insights into issues concerned with the function, origin and evolution of genes and proteins. The functions of proteins and their domains are defined mostly by functional sites. The relation...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Medvedeva I,Demenkov P,Kolchanov N,Ivanisenko V

    更新日期:2012-01-01 00:00:00

  • The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis.

    abstract::The MPI Bioinformatics Toolkit ( is an open, interactive web service for comprehensive and collaborative protein bioinformatic analysis. It offers a wide array of interconnected, state-of-the-art bioinformatics tools to experts and non-experts alike, developed both externally (e.g. BLAS...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Alva V,Nam SZ,Söding J,Lupas AN

    更新日期:2016-07-08 00:00:00

  • Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.

    abstract::Members of the pentatricopeptide repeat domain (PPR) protein family bind RNA and are important for post-transcriptional control of organelle gene expression in unicellular eukaryotes, metazoans and plants. They also have a role in human pathology, as mutations in the leucine-rich PPR-containing (LRPPRC) gene cause sev...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Baggio F,Bratic A,Mourier A,Kauppila TE,Tain LS,Kukat C,Habermann B,Partridge L,Larsson NG

    更新日期:2014-12-16 00:00:00

  • PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.

    abstract::Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P approximately PEP is a newly constructed database specialized in documenting human PPBD-c...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Gong W,Zhou D,Ren Y,Wang Y,Zuo Z,Shen Y,Xiao F,Zhu Q,Hong A,Zhou X,Gao X,Li T

    更新日期:2008-01-01 00:00:00

  • Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase.

    abstract::OGG1 initiated base excision repair (BER) is the major pathway for repair of oxidative DNA base damage 8-oxoguanine (8-oxoG). Here, we report that RECQL4 DNA helicase, deficient in the cancer-prone and premature aging Rothmund-Thomson syndrome, physically and functionally interacts with OGG1. RECQL4 promotes catalytic...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Duan S,Han X,Akbari M,Croteau DL,Rasmussen LJ,Bohr VA

    更新日期:2020-07-09 00:00:00

  • A conserved heptamer upstream of the IgH promoter region octamer can be the site of a coordinate protein-DNA interaction.

    abstract::Immunoglobulin genes contain a conserved eight base sequence element 5' to the site of transcription initiation. This octamer can serve as a site for the binding of nuclear proteins which are presumably involved in the cell type specific expression of this family of genes. In studying the binding of nuclear proteins t...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Landolfi NF,Yin XM,Capra JD,Tucker PW

    更新日期:1988-06-24 00:00:00

  • A minor class of 5S rRNA genes in Saccharomyces cerevisiae X2180-1B, one member of which lies adjacent to a Ty transposable element.

    abstract::In Saccharomyces cerevisiae the majority of the genes for 5S rRNA lie within a 9kb rDNA sequence that is present as 100-200 tandemly-repeated copies on Chromosome XII. Following our observations that about 10% of yeast 5S rRNA exists as minor variant sequences, we screened a collection of yeast DNA fragments cloned in...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Piper PW,Lockheart A,Patel N

    更新日期:1984-05-25 00:00:00

  • Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation.

    abstract::This study unveils Mycobacterium smegmatis DinB2 as the founder of a clade of Y-family DNA polymerase that is naturally adept at incorporating ribonucleotides by virtue of a leucine in lieu of a canonical aromatic steric gate. DinB2 efficiently scavenges limiting dNTP and rNTP substrates in the presence of manganese. ...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Ordonez H,Uson ML,Shuman S

    更新日期:2014-01-01 00:00:00

  • Foreign transcriptional enhancers in yeast. I. Interactions of papovavirus transcriptional enhancers and a quiescent pseudopromoter on supercoiled plasmids.

    abstract::We have constructed simple test-plasmids to study transcriptional enhancers in yeast. In this paper the reporter-gene is a plasmid borne deletion-substitution derivative (his-del4) of the Saccharomyces cerevisiae HIS3 gene in which the native promoter has been replaced by a dormant, susceptible pseudopromoter. We inve...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Ciaramella M,Sacco M,Pulitzer JF

    更新日期:1988-09-26 00:00:00

  • Comparison of nucleotide sequences of large T1 ribonuclease fragments of 18S ribosomal RNA of rat and chicken.

    abstract::Nucleotide sequences of large T1 ribonuclease fragments of 18S ribosomal RNA of Novikoff rat ascites hepatoma cells and chicken lymphoblastoid cells were determined and compared. Among the 19 large T1 ribonuclease fragments examined of rat 18S ribosomal RNA, 12 fragments were found to be the same in chicken 18S riboso...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Fuke M,Busch H

    更新日期:1979-11-10 00:00:00

  • Next-generation RNA-based fluorescent biosensors enable anaerobic detection of cyclic di-GMP.

    abstract::Bacteria occupy a diverse set of environmental niches with differing oxygen availability. Anaerobic environments such as mammalian digestive tracts and industrial reactors harbor an abundance of both obligate and facultative anaerobes, many of which play significant roles in human health and biomanufacturing. Studying...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Wang XC,Wilson SC,Hammond MC

    更新日期:2016-09-30 00:00:00

  • IntAct--open source resource for molecular interaction data.

    abstract::IntAct is an open source database and software suite for modeling, storing and analyzing molecular interaction data. The data available in the database originates entirely from published literature and is manually annotated by expert biologists to a high level of detail, including experimental methods, conditions and ...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kerrien S,Alam-Faruque Y,Aranda B,Bancarz I,Bridge A,Derow C,Dimmer E,Feuermann M,Friedrichsen A,Huntley R,Kohler C,Khadake J,Leroy C,Liban A,Lieftink C,Montecchi-Palazzi L,Orchard S,Risse J,Robbe K,Roechert B,Tho

    更新日期:2007-01-01 00:00:00

  • Open TG-GATEs: a large-scale toxicogenomics database.

    abstract::Toxicogenomics focuses on assessing the safety of compounds using gene expression profiles. Gene expression signatures from large toxicogenomics databases are expected to perform better than small databases in identifying biomarkers for the prediction and evaluation of drug safety based on a compound's toxicological m...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Igarashi Y,Nakatsu N,Yamashita T,Ono A,Ohno Y,Urushidani T,Yamada H

    更新日期:2015-01-01 00:00:00

  • Protein kinase NII and the regulation of rDNA transcription in mammalian cells.

    abstract::Transcription of ribosomal RNA genes is generally accepted to correlate with cell growth. Using primary cultures of adult bovine aortic endothelial (ABAE) cells, we have shown that transcription of rDNA in confluent cells falls to 5% of the transcription level in growing cells. Protein kinase NII appears to be a limit...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Belenguer P,Baldin V,Mathieu C,Prats H,Bensaid M,Bouche G,Amalric F

    更新日期:1989-08-25 00:00:00

  • Mitochondrial transcription termination factor 1 directs polar replication fork pausing.

    abstract::During replication of nuclear ribosomal DNA (rDNA), clashes with the transcription apparatus can cause replication fork collapse and genomic instability. To avoid this problem, a replication fork barrier protein is situated downstream of rDNA, there preventing replication in the direction opposite rDNA transcription. ...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Shi Y,Posse V,Zhu X,Hyvärinen AK,Jacobs HT,Falkenberg M,Gustafsson CM

    更新日期:2016-07-08 00:00:00

  • In vitro non-viral gene delivery with nanofibrous scaffolds.

    abstract::Extracellular and intracellular barriers typically prevent non-viral gene vectors from having an effective transfection efficiency. Formulation of a gene delivery vehicle that can overcome the barriers is a key step for successful tissue regeneration. We have developed a novel core-shelled DNA nanoparticle by invoking...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Liang D,Luu YK,Kim K,Hsiao BS,Hadjiargyrou M,Chu B

    更新日期:2005-11-03 00:00:00

  • Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.

    abstract::Human La protein is an essential factor in the biology of both coding and non-coding RNAs. In the nucleus, La binds primarily to 3' oligoU containing RNAs, while in the cytoplasm La interacts with an array of different mRNAs lacking a 3' UUU(OH) trailer. An example of the latter is the binding of La to the IRES domain...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Martino L,Pennell S,Kelly G,Bui TT,Kotik-Kogan O,Smerdon SJ,Drake AF,Curry S,Conte MR

    更新日期:2012-02-01 00:00:00

  • HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements.

    abstract::7SK snRNA, an abundant RNA discovered in human nucleus, regulates transcription by RNA polymerase II (RNAPII). It sequesters and inhibits the transcription elongation factor P-TEFb which, by phosphorylation of RNAPII, switches transcription from initiation to processive elongation and relieves pauses of transcription....

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Lebars I,Martinez-Zapien D,Durand A,Coutant J,Kieffer B,Dock-Bregeon AC

    更新日期:2010-11-01 00:00:00

  • RadA protein from Archaeoglobus fulgidus forms rings, nucleoprotein filaments and catalyses homologous recombination.

    abstract::Proteins that catalyse homologous recombination have been identified in all living organisms and are essential for the repair of damaged DNA as well as for the generation of genetic diversity. In bacteria homologous recombination is performed by the RecA protein, whereas in the eukarya a related protein called Rad51 i...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: McIlwraith MJ,Hall DR,Stasiak AZ,Stasiak A,Wigley DB,West SC

    更新日期:2001-11-15 00:00:00

  • Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells.

    abstract::We have studied the effect of selenium on the expression of a cellular glutathione peroxidase, GSHPx-1, in transfected MCF-7 cells and in doxorubicin-resistant (Adrr) MCF-7 cells. A GSHPx-1 cDNA with a Rous Sarcoma virus promoter was transfected into a human mammary carcinoma cell line, MCF-7, which has very low endog...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Chu FF,Esworthy RS,Akman S,Doroshow JH

    更新日期:1990-03-25 00:00:00

  • Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition.

    abstract::A correlation between histone acetylation and transcription has been noted for a long time, but little is known about what step(s) in the transcription cycle is influenced by acetylation. We have examined the immediate transcriptional response to histone deacetylase (HDAC) inhibition, and find that release of promoter...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Vaid R,Wen J,Mannervik M

    更新日期:2020-05-21 00:00:00

  • Genetic analysis of L123 of the tRNA-mimicking eukaryote release factor eRF1, an amino acid residue critical for discrimination of stop codons.

    abstract::In eukaryotes, the tRNA-mimicking polypeptide-chain release factor, eRF1, decodes stop codons on the ribosome in a complex with eRF3; this complex exhibits striking structural similarity to the tRNA-eEF1A-GTP complex. Although amino acid residues or motifs of eRF1 that are critical for stop codon discrimination have b...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Saito K,Ito K

    更新日期:2015-05-19 00:00:00

  • The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers.

    abstract::We have isolated a human cDNA (kup), encoding a new protein with two distantly spaced zinc fingers of the C2H2 type. This gene is highly conserved in mammals and is expressed mainly in hematopoietic cells and testis. Its expression was not higher in the various transformed cells tested than in the normal corresponding...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Chardin P,Courtois G,Mattei MG,Gisselbrecht S

    更新日期:1991-04-11 00:00:00

  • NF-kappa B-independent activation of beta-interferon expression in mouse F9 embryonal carcinoma cells.

    abstract::We have examined the behaviour of the beta-interferon promoter in mouse F9 embryonal carcinoma cells. In undifferentiated cells, the beta-interferon promoter is not responsive to dsRNA or to Sendai virus. In cells stimulated to differentiate into parietal endoderm by treatment with retinoic acid, the beta-interferon p...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Ellis MJ,Goodbourn S

    更新日期:1994-10-25 00:00:00

  • UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.

    abstract::The 5'- and 3'-untranslated regions (5'- and 3'-UTRs) of eukaryotic mRNAs are known to play a crucial role in post-transcriptional regulation of gene expression modulating nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and stability. UTRdb is a specialized database of 5' and 3' unt...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Pesole G,Liuni S,Grillo G,Licciulli F,Mignone F,Gissi C,Saccone C

    更新日期:2002-01-01 00:00:00

  • Remarkable acceleration of a DNA/RNA inter-strand functionality transfer reaction to modify a cytosine residue: the proximity effect via complexation with a metal cation.

    abstract::Modified nucleosides in natural RNA molecules are essential for their functions. Non-natural nucleoside analogues have been introduced into RNA to manipulate its structure and function. We have recently developed a new strategy for the in situ modification of RNA based on the functionality transfer reaction between an...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Jitsuzaki D,Onizuka K,Nishimoto A,Oshiro I,Taniguchi Y,Sasaki S

    更新日期:2014-07-01 00:00:00

  • Detection of base analogs incorporated during DNA replication by nanopore sequencing.

    abstract::DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no single method can identify the location, direction and speed of replication forks with high resolution. Mammalian cells have the ability to incorporate thymidine analogs along with the natural A, T, G and C bases during DNA synthe...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Georgieva D,Liu Q,Wang K,Egli D

    更新日期:2020-09-04 00:00:00

  • DNA microstructure influences selective binding of small molecules designed to target mixed-site DNA sequences.

    abstract::Specific targeting of protein–nucleic acid interactions is an area of current interest, for example, in the regulation of gene-expression. Most transcription factor proteins bind in the DNA major groove; however, we are interested in an approach using small molecules to target the minor groove to control expression by...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Laughlin-Toth S,Carter EK,Ivanov I,Wilson WD

    更新日期:2017-02-17 00:00:00