Abstract:
:Genome-wide mapping in the identification of novel candidate genes has always been the standard method in genetics and genomics to correlate a clinically interesting phenotypic trait with a genotype. However, the performance of a mapping experiment using classical microsatellite approaches can be very time consuming. The high-throughput analysis of single-nucleotide polymorphisms (SNPs) has the potential of being the successor of microsatellite analysis routinely used for these mapping approaches, where one of the major obstacles is the design of the appropriate SNP marker set itself. Here we report on ARTS, an advanced retrieval tool for SNPs, which allows researchers to comb freely the public mouse dbSNP database for multiple reference and test strains. Several filters can be applied in order to improve the sensitivity and the specificity of the search results. By employing the panel generator function of this program, it is possible to abbreviate the extraction of reliable sequence data for a large marker panel including several different mouse strains from days to minutes. The concept of ARTS is easily adaptable to other species for which SNP databases are available, making it a versatile tool for the use of SNPs as markers for genotyping. The web interface is accessible at http://andromeda.gsf.de/arts.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Klaften M,Hrabé de Angelis Mdoi
10.1093/nar/gki430keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
W496-500issue
Web Server issueeissn
0305-1048issn
1362-4962pii
33/suppl_2/W496journal_volume
33pub_type
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journal_title:Nucleic acids research
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更新日期:1983-05-25 00:00:00
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