Abstract:
:A dual-specificity, paralogue-free Cdc14 phosphatase was located in the nuclei of Beauveria bassiana (filamentous entomopathogen) and functionally characterized. Inactivation of cdc14 caused defective cytokinesis due to multinucleate cells formed in Δcdc14 and 89% decrease of blastospore production, followed by slower growth and a loss of ≥ 96% conidial yield under normal conditions. These defects coincided well with drastic down-regulation of 25 genes required for mitosis and conidiation. Moreover, Δcdc14 became hypersensitive to oxidative, osmotic, and cell wall and mitosis perturbing stresses, and lost 41-70% of conidial thermotolerance, UV-B resistance and virulence, accompanied with transcriptional down-regualtion of various signaling factors and stress-responsive effectors and depressed phosphorylation signals of Hog1 and Slt2 in high-osmolarity glycerol and cell-wall integrity pathways. All changes were well restored by rescuing cdc14. Our findings indicate that Cdc14 vital for the fungal cytokinesis acts as a signaling hub in regulating not only asexual development but multi-stress responses and virulence.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang J,Liu J,Hu Y,Ying SH,Feng MGdoi
10.1038/srep03086subject
Has Abstractpub_date
2013-10-30 00:00:00pages
3086issn
2045-2322pii
srep03086journal_volume
3pub_type
杂志文章abstract::Cell therapies that invoke pleiotropic mechanisms may facilitate functional recovery in patients with stroke. Based on previous experiments using microglia preconditioned by oxygen-glucose deprivation, we hypothesized that the administration of peripheral blood mononuclear cells (PBMCs) preconditioned by oxygen-glucos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53418-5
更新日期:2019-11-14 00:00:00
abstract::Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measured using genetically...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09426-4
更新日期:2017-08-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-72315-w
更新日期:2020-09-29 00:00:00
abstract::The human brain contains areas that respond selectively to faces, bodies and scenes. Neuroimaging studies have shown that a subset of these areas preferentially respond more to moving than static stimuli, but the reasons for this functional dissociation remain unclear. In the present study, we simultaneously mapped th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44663-9
更新日期:2019-06-03 00:00:00
abstract::In the field of neuroprosthetics, the current state-of-the-art method involves controlling the prosthesis with electromyography (EMG) or electrooculography/electroencephalography (EOG/EEG). However, these systems are both expensive and time consuming to calibrate, susceptible to interference, and require a lengthy lea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73250-6
更新日期:2020-10-01 00:00:00
abstract::Agriculture, forestry and other land uses are currently the second highest source of anthropogenic greenhouse gases (GHGs) emissions. In soil, these gases derive from microbial activity, during carbon (C) and nitrogen (N) cycling. To investigate how Eucalyptus land use and growth period impact the microbial community,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66004-x
更新日期:2020-06-03 00:00:00
abstract::Circulation through cerebral collaterals can maintain tissue viability until reperfusion is achieved. However, collateral circulation is time limited, and failure of collaterals is accelerated in the aged. Remote ischemic perconditioning (RIPerC), which involves inducing a series of repetitive, transient peripheral cy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69122-8
更新日期:2020-07-24 00:00:00
abstract::Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes. Their full-length structures remain unknown, which is a limiting factor in the study of outer membrane fusion. We investigated the structure and dynamics of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10687-2
更新日期:2017-08-31 00:00:00
abstract::More than 12 GW of offshore wind turbines are currently in operation in European waters. To optimise the use of the marine areas, wind farms are typically clustered in units of several hundred turbines. Understanding wakes of wind farms, which is the region of momentum and energy deficit downwind, is important for opt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20389-y
更新日期:2018-02-01 00:00:00
abstract::In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69427-8
更新日期:2020-07-24 00:00:00
abstract::The 8th edition of TNM staging system has been released and it incorporates many changes to the T and N classifications for pancreatic cancer. Comparative study between the 7th and 8th edition of TNM staging system from Asian population has not been reported yet. This study aimed to compare the 7th and 8th edition of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28193-4
更新日期:2018-07-10 00:00:00
abstract::Phase distribution of emerging organic contaminants is highly influential in their presence, fate and transport in surface water. Therefore, it is crucial to determine their state, partitioning behaviour and tendencies in water environments. In this study, Bisphenol A was investigated in both colloidal and soluble pha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77454-8
更新日期:2020-11-23 00:00:00
abstract::Sexual spores are important for the dispersal and population dynamics of fungi. They show remarkable morphological diversity, but the underlying forces driving spore evolution are poorly known. We investigated whether trophic status and substrate associations are associated with morphology in 787 macrofungal genera. W...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23292-8
更新日期:2018-03-29 00:00:00
abstract::Chemical chaperones including arginine and its derivatives are widely used by biochemists working on the design of agents, which are able to efficiently suppress protein aggregation. To elucidate the mechanisms of anti-aggregation activity of chemical chaperones, methods based on registration of the increment in light...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04409-x
更新日期:2017-06-21 00:00:00
abstract::Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24019
更新日期:2016-04-07 00:00:00
abstract::Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcriptional control mechanisms specifying the progenitor cells (i.e. prosen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45515-2
更新日期:2019-06-21 00:00:00
abstract::Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. Human embr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17685
更新日期:2015-12-02 00:00:00
abstract::The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80812-1
更新日期:2021-01-14 00:00:00
abstract::Gentamicin may cause acute kidney injury. The pathogenesis of gentamicin nephrotoxicity is unclear. Autophagy is a highly conserved physiological process involved in removing damaged or aged biological macromolecules and organelles from the cytoplasm. The role of autophagy in the pathogenesis of gentamicin nephrotoxic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11256
更新日期:2015-06-08 00:00:00
abstract::Iron is an essential mineral required for most forms of life. However, very little is known in relation to the different forms of dietary iron on the development of NAFLD. The aims of this study were to investigate the effects of iron intake from different food types on risk of NAFLD and whether this effect may be mod...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40449-1
更新日期:2019-03-11 00:00:00
abstract::Iron deposits are a phenotypic trait of tumor-associated macrophages (TAMs). Histological iron imaging and contrast-agent free magnetic resonance imaging (MRI) can detect these deposits, but their presence in human cancer, and correlation with immunotherapeutic response is largely untested. Here, primarily using thes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37408-7
更新日期:2019-01-29 00:00:00
abstract::At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40900
更新日期:2017-01-20 00:00:00
abstract::N-α-acetyltransferase 10 (Naa10) displays alpha (N-terminal) acetyltransferase activity. It functions as a major modulator of cell growth and differentiation. Until now, a few downstream targets were found, but no studies have concerned about which gene is the early event of Naa10 downstream target. As we know, the ea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38508
更新日期:2016-12-02 00:00:00
abstract::The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40200
更新日期:2017-01-10 00:00:00
abstract::The Anfinsen hypothesis, the demonstration of which led to the Nobel prize in Chemistry, posits that all information required to determine a proteins' three dimensional structure is contained within its amino acid sequence. This suggests that it should be possible, in theory, to fold any protein in vitro. In practice,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18906
更新日期:2016-01-19 00:00:00
abstract::This systematic review and meta-analysis was designed to investigate whether maternal psychological stress and recent life events are associated with an increased risk of miscarriage. A literature search was conducted to identify studies reporting miscarriage in women with and without history of exposure to psychologi...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-01792-3
更新日期:2017-05-11 00:00:00
abstract::Acanthamoeba can cause visually destructive Acanthamoeba keratitis (AK) in contact lens (CL) users. The purpose of this study was to determine whether Acanthamoeba was present in the CL cases of CL wearers and to develop techniques to prevent the contaminations. To accomplish this, 512 CL case samples were collected f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69554-2
更新日期:2020-07-28 00:00:00
abstract::Concurrent generation and mixing phenomenon of thermoacoustic (TA) and magnetoacoustic (MA) waves in water are predicted and observed. A theory unifying TA and MA is further put forward to analyze it. By scaling down the radio frequency in thermoacoustics to the low mega Hertz range and by incorporating appropriately ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11489
更新日期:2015-06-26 00:00:00
abstract::Cyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium Synechocystis sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22168
更新日期:2016-02-29 00:00:00
abstract::Rice black-streaked dwarf disease, caused by rice black-streaked dwarf virus (RBSDV), is transmitted by small brown planthoppers (Laodelphax striatellus Fallén, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to RBSDV is a promising strategy to cont...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10509
更新日期:2015-07-22 00:00:00